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Sonja Fritzsche

@sonjafritzsche.bsky.social

👩‍🔬 PhD Student @CosciaLab.bsky.social @MDC-berlin.bsky.social 🧬 Interested in Cancer and Multiomics 🔬 Combining Multiplex Imaging and Single-Cell Mass Spectrometry

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Coscia Lab @coscialab.bsky.social · last yr.

Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution. Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4

An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day

Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...

bit.ly

Coscia Lab @coscialab.bsky.social · last yr.

Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes: – A simplified fast-track pipeline for easy adoption – An AI-powered option for advanced image & spatial analysis 👉 BioRxiv: bit.ly/44SBuHu 👉 Github: bit.ly/4eR3IqK

Tancredi M Pentimalli @tmpentimalli.bsky.social · last yr.

www.cell.com/cell-systems... CosMx data by @brukerspatial.bsky.social Second harmonics by Andrew Woehler Immunofluorescence by @sonjafritzsche.bsky.social and @josenimo.bsky.social in Fabian Coscia lab STIM for 3D alignment by @preibischs.bsky.social @nukappa.bsky.social et al (coming very soon!)

Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment

Pentimalli et al. extend imaging-based spatial transcriptomics to 3D and combine it with ECM profiling. The multimodal analysis of cellular neighborhoods in a clinical lung adenocarcinoma sample revea...

cell.com

Coscia Lab @coscialab.bsky.social · last yr.

Our lab's newest preprint is out on deep spatial proteomics of ovarian cancer precursor lesions! We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets. bit.ly/41M7fke

Deep spatial proteomics of ovarian cancer precursor lesions delineates early disease changes and cell-of-origin signatures

High-grade serous ovarian cancer (HGSOC) is a devastating disease that is frequently detected at an advanced and incurable stage. Advances in ultrasensitive mass spectrometry-based spatial proteomics ...

biorxiv.org