Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels - Nature Neuroscience

The authors show that cerebral venous blood flow and meningeal lymphatics co-regulate intracranial pressure and brain clearance in mice and humans. This finding supports idiopathic intracranial hypert...

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More muscle, less belly fat: mutations to a gene are linked to wide-ranging benefits

Analysis of one million diverse genomes yields mutations associated with lower risk of diabetes, heart disease and other ‘cardiometabolic’ conditions.

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LMNA p.H222P mutation causes contractile dysfunction via impaired mitochondrial calcium uptake in human cardiac laminopathy

AbstractAims. Mutations in the LMNA gene, which encodes lamin A/C, cause a variety of diseases known as laminopathies. Some mutations are particularly asso

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The origin of clinical left ventricular ejection fraction measurement

Nature Reviews Cardiology, Published online: 03 July 2026; doi:10.1038/s41569-026-01321-8The authors highlight the first report of the measurement of left ventricular ejection fraction in humans, published in 1962 by Roland Folse and Eugene Braunwald.

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Primary aldosteronism - Nature Reviews Disease Primers

In this Primer, Vaidya and colleagues review the epidemiology, pathophysiology, diagnosis, management and quality of life of patients with primary aldosteronism, an important cause of hypertension res...

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Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathy - Pediatric Research

Pediatric Research - Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathy

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Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis

Nature Reviews Cardiology, Published online: 22 June 2026; doi:10.1038/s41569-026-01318-3A study in Nature reports that in mice, healthy lifestyle behaviours, including exercise and uninterrupted sleep, can limit clone expansion in clonal haematopoiesis and promote the phenotypic reprogramming of clonal haematopoiesis mutant cells, thereby reducing the risk of atherosclerosis.

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Europe as science superpower: what it will take to rival the US and China

Amid chaos in US science and geopolitical turmoil, Europe wants to position itself as a research haven — but questions about funding and innovation remain.

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Epigenetic regulation in atherosclerosis and its therapeutic potential

Nature Reviews Cardiology, Published online: 19 June 2026; doi:10.1038/s41569-026-01313-8In this Review, Santovito and colleagues provide an overview of epigenetic regulation in atherosclerosis, focusing on how epigenetic modifications guide cell-specific transcriptional programmes in vascular endothelial cells, vascular smooth muscle cells, and immune cells to regulate cell plasticity and intercellular communication. They also discuss translational opportunities and the challenges of using epigenetic drugs to treat atherosclerotic cardiovascular disease.

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Heart rate monitoring during everyday use of smartphones

Nature Reviews Cardiology, Published online: 15 June 2026; doi:10.1038/s41569-026-01316-5Researchers have developed a deep learning system that uses short videos of the face passively recorded during everyday use of smartphones to monitor heart rate and resting heart rate. The system was validated under laboratory and free-living conditions and across a range of skin tones.

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Inflammatory cell death and monocyte dysfunction in VEXAS syndrome

Key PointsUBA1-mutated monocytes are susceptible to RIPK1-dependent cell death and display impaired NF-κB–mediated cytokine responses to TLR agonists.UBA1-

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Soluble CD146 reflects altered endothelial and metabolic homeostasis in peripheral artery disease - Angiogenesis

Background Peripheral Arterial Disease (PAD) is a prevalent but underdiagnosed pathology. Soluble CD146 (sCD146) was described as a marker of endothelial dysfunction and vascular congestion. Objective...

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Promising results with stem-cell-derived tissue transplantation in heart failure

Nature Reviews Cardiology, Published online: 09 June 2026; doi:10.1038/s41569-026-01315-6In patients with advanced, symptomatic heart failure with reduced ejection fraction refractory to guideline-directed therapy, transplantation of a tissue allograft produced from induced pluripotent stem cells promotes heart remuscularization and leads to increases in heart wall thickness, left ventricular ejection fraction and quality of life at 3 months, according to an interim analysis of the ongoing, phase I–II BioVAT-HF clinical trial.

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The direction of cardiomyocyte growth is orchestrated by microtubule dynamics

Nature Reviews Cardiology, Published online: 04 June 2026; doi:10.1038/s41569-026-01311-wA new study shows that the microtube network directs cardiomyocyte growth through two mechanisms: by redirecting the localization of mRNA and protein synthesis and by modifying the intercalated disc, the site of cell–cell adhesion at the ends of the cardiomyocyte.

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Passive heart-rate monitoring during smartphone use in everyday life - Nature

A machine-learning model that uses smartphone cameras to measure heart rate in the background during normal daily phone use and subsequently estimate resting heart rate could make it easier for people to monitor heart health.

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First and last authors more likely to be men in leading science journals

Women’s participation in science has risen sharply, but a Nature Index analysis finds that gender gaps in first and last authorship — markers of key scientific achievements — have barely shifted over the past decade.

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PA Collection Genetics and PA: Disease Phenotype and Demographic Implications for Hypertension | Hypertension

Detecting secondary forms of hypertension is key to targeted management and prevention of cardiovascular complications. Primary aldosteronism (PA) is the most common form of secondary arterial hyperte...

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Gene therapies to fix failing hearts gain steam after years in the doldrums

Treatments aim to bulk up failing hearts to restore their vigour – but can the field move on from past controversy?

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Universal transcriptomic hallmarks of mammalian ageing and mortality - Nature

Integration of gene expression data from multiple tissues across four mammalian species reveals conserved transcriptomic signatures of mammalian ageing and mortality and uncovers the modular architecture of ageing and mortality hallmarks.

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Gene-expression patterns can be used to estimate mortality risk and chronological age

Massive analyses of RNA transcripts from rodents, monkeys and humans reveal hallmarks of ageing that could expedite the development of anti-ageing interventions.

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