Multimodal precision diagnostics in clinical xenotransplantation - Nature

Now that hyperacute rejection of pig xenografts can be reliably prevented, subtler immune-mediated graft injuries have emerged that conventional diagnostics often miss; a multimodal precision diagnost...

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X and Y chromosomes as determinants of aging and disease

Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX a...

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Reducing the burden of heat-related impacts on cardiovascular health: A statement of the Association of Cardiovascular Nursing & Allied Professions (ACNAP), the Association for Acute CardioVascular Ca...

Abstract. Heat extremes significantly increase morbidity and mortality, particularly among older adults and people with cardiovascular disease (CVD). The y

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Dynamics of human cardiogenesis and its disruption in trisomy 21 - Nature

Single-cell and spatial multiomics are combined to define niches in the developing human heart, revealing pacemaker-cell organization, cardiomyocyte maturation and compaction, and developmental perturbations associated with trisomy 21.

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Revealed: How this common gut microbe protects against heart disease

Nature - Intestinal bacterium secretes a molecule that reduces cholesterol production, according to a mouse study.

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Multimodal data-driven clustering analysis of heart failure patients identifies two distinct patterns of heart failure with preserved ejection fraction: Results from the PACIFIC-PRESERVED study - Natu...

Heart failure with preserved ejection fraction is clinically heterogeneous, complicating efforts to identify patients at highest risk. Here, the authors show that integrating proteomics with machine l...

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Redesigning cardiovascular medicine around sex differences - Nature Medicine

Connecting evidence across preclinical and clinical domains, this Perspective calls for a greater understanding of sex-biased mechanisms and integration of these insights into diagnostics and therapeu...

nature.com

Global inequalities in cardiometabolic care and achievable cardiovascular risk reduction by wealth, region, and sex: a pooled analysis of individual participant data from 76 countries

The populations with the largest treatment gaps are not necessarily those that could achieve the greatest absolute reduction in cardiovascular risk through treating individuals who are currently untre...

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Successful early-career scientists rely on network of mentors

Large networks are particularly beneficial to researchers in under-represented groups.

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The CXCL12γ/ACKR3 Axis Is a Critical Determinant of Myocardial Angiogenesis and Functional Recovery After Infarction:

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AI-enabled clinical trials - Nature Reviews Bioengineering

Artificial intelligence is poised to reshape clinical trials, addressing challenges in design, recruitment, monitoring and conduct. This Review outlines a framework built on deeply phenotyped cohorts,...

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Acute heart failure in Africa: new causes, unchanged outcomes

More than 15 years ago, the original Sub-Saharan Africa Survey of Heart Failure (THESUS-HF) provided one of the first prospective, multinational descriptions of acute heart failure in sub-Saharan Afri...

thelancet.com

ORAI Ca2+ channels and STIM1 drive capillary-to-arteriole communication in neurovascular coupling

Sustained cerebral arteriole dilation requires ORAI1-mediated Ca2+ influx in capillary endothelial cells.

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Tracing the origins of de novo coronary collateral formation in cardiac repair

Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from preexisting arteries and reassemble int...

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Explaining Variance in Pulse Wave Velocity in Youth: The Youth Vascular Consortium | Hypertension

BACKGROUND: Cardiovascular disease is a leading cause of global mortality. Carotid-femoral pulse wave velocity (cfPWV) is the gold-standard noninvasive measure of arterial stiffness and is commonly us...

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Artificial Intelligence-Enabled Electrocardiography for Detection of Left Ventricular Diastolic Dysfunction: A Systematic Review and Meta-Analysis

AbstractBackground. Left ventricular diastolic dysfunction (LVDD) is an early precursor to heart failure with preserved ejection fraction (HFpEF) and it is

doi.org

Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels - Nature Neuroscience

The authors show that cerebral venous blood flow and meningeal lymphatics co-regulate intracranial pressure and brain clearance in mice and humans. This finding supports idiopathic intracranial hypert...

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More muscle, less belly fat: mutations to a gene are linked to wide-ranging benefits

Analysis of one million diverse genomes yields mutations associated with lower risk of diabetes, heart disease and other ‘cardiometabolic’ conditions.

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LMNA p.H222P mutation causes contractile dysfunction via impaired mitochondrial calcium uptake in human cardiac laminopathy

AbstractAims. Mutations in the LMNA gene, which encodes lamin A/C, cause a variety of diseases known as laminopathies. Some mutations are particularly asso

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The origin of clinical left ventricular ejection fraction measurement

Nature Reviews Cardiology, Published online: 03 July 2026; doi:10.1038/s41569-026-01321-8The authors highlight the first report of the measurement of left ventricular ejection fraction in humans, published in 1962 by Roland Folse and Eugene Braunwald.

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Primary aldosteronism - Nature Reviews Disease Primers

In this Primer, Vaidya and colleagues review the epidemiology, pathophysiology, diagnosis, management and quality of life of patients with primary aldosteronism, an important cause of hypertension res...

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Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathy - Pediatric Research

Pediatric Research - Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathy

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