The most successful early-career researchers often rely on a network of mentors who each have different roles — from advising on research and grants to making professional introductions and providing emotional support go.nature.com/46U5PXy
Successful early-career scientists rely on network of mentors
Large networks are particularly beneficial to researchers in under-represented groups.
go.nature.com
Some intrepid animals don’t stop fighting for their lives, even after they’ve been eaten. X-ray video from a 2024 study reveals one such daring escape. Learn more: https://scim.ag/4xgpBqX #ScienceMagArchives
JS Silvestre's Team identifies the CXCL12γ-ACKR3 axis as a previously unrecognized driver of post-myocardial infarction recovery. Read more: www.jacc.org/doi/10.1016/...
The CXCL12γ/ACKR3 Axis Is a Critical Determinant of Myocardial Angiogenesis and Functional Recovery After Infarction:
jacc.org
In this review, M Raynaud and A Loupy suggest that AI-enabled clinical trials could shorten timelines, reduce costs and accelerate both the identification of effective therapies and the earlier elimination of futile ones. Read More: www.nature.com/articles/s44...
AI-enabled clinical trials - Nature Reviews Bioengineering
Artificial intelligence is poised to reshape clinical trials, addressing challenges in design, recruitment, monitoring and conduct. This Review outlines a framework built on deeply phenotyped cohorts,...
nature.com
B Gaye and E Marijon @PARCC comment the results of The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF II) providing invaluable insights into the contemporary characteristics and burden of acute HF in Africa. Read more: www.thelancet.com/journals/lan...
Acute heart failure in Africa: new causes, unchanged outcomes
More than 15 years ago, the original Sub-Saharan Africa Survey of Heart Failure (THESUS-HF) provided one of the first prospective, multinational descriptions of acute heart failure in sub-Saharan Afri...
thelancet.com
ORAI calcium ion channels and the channel regulator STIM1 in capillary endothelial cells are needed to adjust blood flow to support sustained neuronal activity. Deficiencies in these proteins led to dementia-like symptoms in mice. Learn more in #ScienceSignaling: https://scim.ag/4cjOk6n
ORAI Ca2+ channels and STIM1 drive capillary-to-arteriole communication in neurovascular coupling
Sustained cerebral arteriole dilation requires ORAI1-mediated Ca2+ influx in capillary endothelial cells.
scim.ag
Cardiovascular disease is one of the leading causes of maternal mortality & a major driver of morbidity. In our latest issue, a new Lancet Series examines the continuum of cardiovascular risk surrounding pregnancy. Read this & more: spkl.io/633267umrM
New Science research in mice challenges a long-standing view of how the heart builds backup blood vessels after a coronary artery blockage, showing that new collateral arteries arise primarily from capillaries rather than existing arteries. Learn more: https://scim.ag/4xj0TqU
Tracing the origins of de novo coronary collateral formation in cardiac repair
Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from preexisting arteries and reassemble int...
scim.ag
Carotid-femoral pulse wave velocity (cfPWV) is the gold-standard noninvasive measure of arterial stiffness and is used to assess early vascular aging, as it predicts cardiovascular events. This study aimed to explain cfPWV variation in young people. Read More: www.ahajournals.org/doi/10.1161/...
Explaining Variance in Pulse Wave Velocity in Youth: The Youth Vascular Consortium | Hypertension
BACKGROUND: Cardiovascular disease is a leading cause of global mortality. Carotid-femoral pulse wave velocity (cfPWV) is the gold-standard noninvasive measure of arterial stiffness and is commonly us...
ahajournals.org
AI-enhanced electrocardiography demonstrated good diagnostic performance for detecting Left ventricular diastolic dysfunction and may support future rule-out or risk-enrichment strategies in selected populations. Read more : doi.org/10.1093/ehjd...
Artificial Intelligence-Enabled Electrocardiography for Detection of Left Ventricular Diastolic Dysfunction: A Systematic Review and Meta-Analysis
AbstractBackground. Left ventricular diastolic dysfunction (LVDD) is an early precursor to heart failure with preserved ejection fraction (HFpEF) and it is
doi.org
In a study co-authored by K. Boye and A. Eichmann @PARCC, dural venous stenoses in idiopathic intracranial hypertension were linked to brain edema and altered fluid flow. Meningeal lymphatic vessels and venous flow are key to regulating brain pressure. Read More: www.nature.com/articles/s41...
Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels - Nature Neuroscience
The authors show that cerebral venous blood flow and meningeal lymphatics co-regulate intracranial pressure and brain clearance in mice and humans. This finding supports idiopathic intracranial hypert...
nature.com
A massive genomic study has linked mutations in a specific gene to an increased proportion of muscle, decreased levels of belly fat and blood sugar and a reduced risk of conditions including heart disease go.nature.com/4q03zHc
More muscle, less belly fat: mutations to a gene are linked to wide-ranging benefits
Analysis of one million diverse genomes yields mutations associated with lower risk of diabetes, heart disease and other ‘cardiometabolic’ conditions.
go.nature.com
Team Hulot reveals a direct mechanistic link between nuclear envelope dysfunction and impaired mitochondrial function and highlight the MCU complex as a potential therapeutic target in LMNA-related cardiomyopathy. Read more: academic.oup.com/cardiovascre...
LMNA p.H222P mutation causes contractile dysfunction via impaired mitochondrial calcium uptake in human cardiac laminopathy
AbstractAims. Mutations in the LMNA gene, which encodes lamin A/C, cause a variety of diseases known as laminopathies. Some mutations are particularly asso
academic.oup.com
Don’t forget to register for the 5th Immuno-Metabolic Mechanisms of Atherosclerosis Conference taking place in Playa del Carmen, Mexico, on 10–13 Nov 2026 Final registration deadline 11 Aug 2026 Hope to see you at #IMMA in Mexico! Click here to register: bit.ly/4uIAuB9 @fusionconf.bsky.social
Adults with congenital heart disease may experience accelerated biological aging, explaining earlier onset of frailty, cognitive decline & other age-related challenges. 🆕 ACC Expert Analysis explores the potential mechanisms of aging: 🔗https://bit.ly/44iR9QD #CHD #ACHD #ACCACPC #CardioSky
New online! The origin of clinical left ventricular ejection fraction measurement #CardioSky
The origin of clinical left ventricular ejection fraction measurement
Nature Reviews Cardiology, Published online: 03 July 2026; doi:10.1038/s41569-026-01321-8The authors highlight the first report of the measurement of left ventricular ejection fraction in humans, published in 1962 by Roland Folse and Eugene Braunwald.
dlvr.it
In this comprehensive literature review, Zennaro MC and colleagues summarize the current understanding of primary aldosteronism, highlighting that it is a major cause of hypertension associated with increased cardiovascular and renal morbidity. www.nature.com/articles/s41...
Primary aldosteronism - Nature Reviews Disease Primers
In this Primer, Vaidya and colleagues review the epidemiology, pathophysiology, diagnosis, management and quality of life of patients with primary aldosteronism, an important cause of hypertension res...
nature.com
Hulot team shows that BRAF-mutant cardiomyocytes recapitulate the characteristics of hypertrophic cardiomyopathy (HCM). Mavacamten restores energetic balance under stress conditions, indicating it holds potential as a therapeutic option for RASopathy-associated HCM. www.nature.com/articles/s41...
Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathy - Pediatric Research
Pediatric Research - Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathy
nature.com
Frequently ignored bodily rhythms may be skewing neuroscience experiments. Learn more: https://scim.ag/4w5LFVc
La météo annonce la température, mais pas ses conséquences sur notre santé. Vous l’aurez compris, l’affichage est faux mais ces chiffres sont vrais. Notre dernier rapport Oxfam révèle les effets du changement climatique sur la santé : 👉 bit.ly/4xAagCX
New online! Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis #CardioSky
Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis
Nature Reviews Cardiology, Published online: 22 June 2026; doi:10.1038/s41569-026-01318-3A study in Nature reports that in mice, healthy lifestyle behaviours, including exercise and uninterrupted sleep, can limit clone expansion in clonal haematopoiesis and promote the phenotypic reprogramming of clonal haematopoiesis mutant cells, thereby reducing the risk of atherosclerosis.
dlvr.it
Amid chaos in US science and geopolitical turmoil, Europe wants to position itself as a research haven — but questions about funding and innovation remain go.nature.com/4eJVq4l
Europe as science superpower: what it will take to rival the US and China
Amid chaos in US science and geopolitical turmoil, Europe wants to position itself as a research haven — but questions about funding and innovation remain.
go.nature.com
New online! Epigenetic regulation in atherosclerosis and its therapeutic potential #CardioSky
Epigenetic regulation in atherosclerosis and its therapeutic potential
Nature Reviews Cardiology, Published online: 19 June 2026; doi:10.1038/s41569-026-01313-8In this Review, Santovito and colleagues provide an overview of epigenetic regulation in atherosclerosis, focusing on how epigenetic modifications guide cell-specific transcriptional programmes in vascular endothelial cells, vascular smooth muscle cells, and immune cells to regulate cell plasticity and intercellular communication. They also discuss translational opportunities and the challenges of using epigenetic drugs to treat atherosclerotic cardiovascular disease.
dlvr.it
A new hybrid imaging technology integrates 3D photoacoustic tomography and ultrasound localization microscopy, allowing for continuous, noninvasive, whole-brain imaging in mice through an intact skull. Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4esKNTk
New online! Heart rate monitoring during everyday use of smartphones #CardioSky
Heart rate monitoring during everyday use of smartphones
Nature Reviews Cardiology, Published online: 15 June 2026; doi:10.1038/s41569-026-01316-5Researchers have developed a deep learning system that uses short videos of the face passively recorded during everyday use of smartphones to monitor heart rate and resting heart rate. The system was validated under laboratory and free-living conditions and across a range of skin tones.
dlvr.it
Depression affects approximately a quarter of a billion people globally, of all ages and from all walks of life. A Seminar provides a comprehensive overview of the epidemiology, diagnosis, & management of depression in adults: spkl.io/6332478c5y
In VEXAS syndrome, myeloid dysfunction fuels inflammation and cytopenia supporting the therapeutic targeting of inflammatory cell death pathways. ashpublications.org/blood/articl...
Inflammatory cell death and monocyte dysfunction in VEXAS syndrome
Key PointsUBA1-mutated monocytes are susceptible to RIPK1-dependent cell death and display impaired NF-κB–mediated cytokine responses to TLR agonists.UBA1-
ashpublications.org
ICYMI: The INFINITY trial, presented at #ERA2026, found that finerenone reduced the risk of chronic kidney disease progression, including kidney failure alone, and reduced heart failure hospitalisation, cardiovascular death, and all-cause death. Read now: spkl.io/6332678efa
The 2026 AHA/ACC/ADA/ASN #CKM Syndrome Guideline-at-a-Glance covers CKM staging, PREVENT CV risk assessment, obesity & metabolic care, kidney-protective therapies, & more! Get started implementing 🔑 recommendations into everyday practice: https://bit.ly/4emLZrA #JACC #ClinicalGuidelines #CardioSky
Team Smadja reveals that sCD146 may reflect impaired endothelial homeostasis and metabolic dysregulation in peripheral artery disease, indicating that it could serve as a diagnostic biomarker for the pathology. link.springer.com/article/10.1...
Soluble CD146 reflects altered endothelial and metabolic homeostasis in peripheral artery disease - Angiogenesis
Background Peripheral Arterial Disease (PAD) is a prevalent but underdiagnosed pathology. Soluble CD146 (sCD146) was described as a marker of endothelial dysfunction and vascular congestion. Objective...
link.springer.com