My PhD paper is finally out! 🎉 We show how specific LC pathways shape sound-evoked awakening, revealing LC heterogeneity in action. So grateful to all the amazing people who made this possible 🙌

Yuval Nir@labnir.bsky.social · 11mo ago

🚨 New paper alert! 🚨(1/6) Excited to share our work, out now in Science Advances We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings www.science.org/doi/10.1126/...

AAV1 hSyn-PdCO-mScarlet-WPRE is finally available from @addgene.bsky.social 🧪🧠 All resources here: docs.google.com/spreadsheets...

Excited to share our new preprint out on biorxiv! We found a specific LC pathway that influences sensory evoked awakenings from NREM sleep. @labnir.bsky.social #bluespot 🔵 www.biorxiv.org/content/10.1...

An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening

The locus coeruleus norepinephrine (LC-NE) system regulates arousal and awakening; however, it remains unclear whether the LC does this in a global or circuit specific manner. We hypothesized that sen...

biorxiv.org