happy to announce that i have post-doc openings for mid-2016 to advance this science please read our work, think about the most exciting questions & approaches, & be in touch for an interview note that there are now human data in support of our model www.medrxiv.org/content/10.6...

Elevated FGF21 and triglycerides in SLC25A13 carriers support the G3P-ChREBP Citrin Deficiency disease hypothesis

People with Citrin Deficiency (CD), inactivated for both copies of SLC25A13 , have lean metabolic dysfunction-associated steatotic liver disease (MASLD) and an aversion to sweets. The mouse model of C...

medrxiv.org

Nature Metabolism@natmetabolism.nature.com · 8mo ago

RESEARCH | @charlesmbrenner.bsky.social et al @cityofhope.bsky.social In citrin deficiency, accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction🧪

RESEARCH | @charlesmbrenner.bsky.social et al @cityofhope.bsky.social In citrin deficiency, accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction🧪

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency - Nature Metabolism

In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycerol-3-phosphate as a ChREBP-activating ligand, which could resolve paradoxes of FGF21 expression and clarify the logic of lipogenic transcription.

bit.ly

thank you, Christian thanks to @russgoodman.bsky.social @markhermanmd.bsky.social @cnspracklen.bsky.social Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others

Christian Frezza@frezzalab.bsky.social · 9mo ago

www.nature.com/articles/s42... Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency @charlesmbrenner.bsky.social congratulations!

heading to helsinki to join @keisakamoto.bsky.social @awartiovaara.bsky.social and others at tuesday's SWAN meeting: healthy aging, mitochondrial disease, MASLD, rare disease and more!

@charlesmbrenner.bsky.social nice podcast with Drs Nadolsky

happy to say i got a completely routine email today requesting that i ad hoc on an april 2 study section

Drug Monkey@drugmonkey.bsky.social · 2y ago

In case I need to say it, today is a good day to drop an email to your fav PO or SRO and let them know you appreciate them.

thank you, Paul IMO the mystery is why more folks don't call BS when it is so plain to see and why editors continue to review papers from groups that are obfuscatory

Paul Knoepfler@stemcells.bsky.social · 2y ago

Perspectives as Charles Brenner challenges David Sinclair on longevity claims ipscell.com/2025/01/pers... It's rare to see professors going at it like this in public #stemcell #stemcells I tend to agree with @charlesmbrenner.bsky.social and the hype on longevity & in vivo reprogramming bother me

The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety: www.biorxiv.org/content/10.1...

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency

Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...

biorxiv.org

The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety: www.biorxiv.org/content/10.1...

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency

Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...

biorxiv.org

jackson state really brings it

I’m celebrating tonight with my father in law, Jack Strominger, who is about to enjoy his 100th New Years! He wants to know whether any other scientist has published in their 100th year. He’s proud to have a paper in the works. I told him you all would know! Please RT

happy newyearsnukkah 🕎

may it be so again!

Benoit Bruneau@benoitbruneau.bsky.social · 2y ago

for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....

for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....

Just to add to the sad news on #chemsky right now: I've now had it confirmed to me that Martin Karplus died on Saturday.

I convert tax dollars to pdfs

www.biorxiv.org/content/10.1... Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency

Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...

biorxiv.org

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency www.biorxiv.org/content/10.1...

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency

Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...

biorxiv.org

all..... i will fix the post with working links soon as i can

Congrats on the new work, Charles! 🎉 Excited to dive into your findings on ChREBP and FGF21. Your research always brings fresh insights to the table! Keep up the amazing work! #ResearchInnovation #Biochemistry

excited to share new work "Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency" www.biorxiv.org/content/10.1...

Just when it seemed we had uncovered everything about Nampt, the rate-limiting enzyme in salvage NAD+ biosynthesis, first author Shu Feng in @charlesmbrenner.bsky.social lab and colleagues reveal an exciting discovery: Nampt is a protein phosphoribosylase! www.nature.com/articles/s42...

Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins - Nature Metabolism

The NAD+ synthesis enzyme NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase, which restricts the virion incorporation of viral proteins and underpins its antiviral effect

nature.com

yes, refreshing article still a major problem as one small example, @davidasinclair.bsky.social just gave a talk on aging at ARDD he talked about work in a Cell paper that James Timmons & i said should be retracted cell didn't retract but eventually published our critique w a response from david

Paul Knoepfler@stemcells.bsky.social · 2y ago

I should have pinged @charlesmbrenner.bsky.social on this.

Mito disease management is largely symptomatic. A subset respond well to specific vitamins or cofactors, but evidence of benefit in most is poor although prescribing is common. A survey of global vitamin & cofactor prescribing practices in PMD. 👉 doi.org/10.1002/jimd... @jhpark.bsky.social

Some inner ear hair cells for #FluorescenceFriday. A new audience for an old image. 🧪👂 #cilia #neuroskyence

the brenner-knoller dogs

J. David Jentsch 🏳️‍🌈@jdavidjentsch.bsky.social · 2y ago

I was wondering what bluesky is lacking in, and then it occurred to me: pics of the Jentsch dogs!