So happy to share our latest review on how post-translational modifications of SQSTM1, including S-acylation, regulate autophagy in neurodegeneration. www.tandfonline.com/doi/full/10....

Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration

SQSTM1/p62 (sequestosome 1) is an important receptor protein involved in many cellular signaling processes, including macroautophagy/autophagy. It is a molecular hub for cellular homeostasis and ce...

tandfonline.com

This was led by former MSc Fatima Abrar in my lab. After publishing (after getting scooped) our work on S-acylation of SQSTM1/p62 in Huntington Disease, Fatima wanted to her work into context of all PTMs. FYI, Fatima is looking for a PhD position in Germany. Please DM me to connect you with Fatima.

DMartin@drddom.bsky.social · 3mo ago

So happy to share our latest review on how post-translational modifications of SQSTM1, including S-acylation, regulate autophagy in neurodegeneration. www.tandfonline.com/doi/full/10....

Excited to share we identified an S-acylation motif & used it to develop a new S-acylation prediction program! @drssfs.bsky.social

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program

S-acylation, the reversible addition of fatty acids to proteins, has emerged as an abundant post-translational modification that drives protein localization and function. With no known consensus seque...

biorxiv.org

What an incredible turnout for @alscanada.bsky.social #WalkToEndALS at @uwaterloo.ca! 250-300 people came to raise funds & awareness for ALS. We hit our target & then some! Thank you to everyone who came out & @waterloosci for all your support! alscanadawalktoendals.als.ca/ontario2026/...

Today marks the first day for the Walks to End ALS & ours is happening today! Please consider donating here. Or if you're in the Waterloo area come join us! We'll be at the @uwaterloo.ca alscanadawalktoendals.als.ca/ontario2026/...

2026 Walk to End ALS - Ontario : Kitchener/Waterloo

REGISTER SEARCH Participants & Teams Date: Saturday, June 6thLocation: University of WaterlooAddress: 200 University Ave W, Waterloo, ON N2L 3G1Contact: info@walktoendals.ca Registration Time: 10:00 A...

alscanadawalktoendals.als.ca

Happy to announce (albeit delayed) that @uwaterloo.ca @waterloosci.bsky.social & the NeurdyPhagy Lab are hosting the local #WalkToEndALS this Saturday June 6th. Please join us or consider making a donation here: alscanadawalktoendals.als.ca/ontario2026/...

Very excited to share our preprint showing S-acylation (aka Palmitoylation) of TDP-43, VCP, SQSTM1, FUS & C9Orf72 in Huntington Disease (HD), Amyotrophic Lateral Sclerosis (ALS), & Multisystem Proteinopathy (MSP). This tour de force was led by @firyalrphd.bsky.social! www.biorxiv.org/content/10.6...

#JNeurosci Review | Perry and Martin discuss the links between ALS and Huntington Disease, highlighting two proteins that potentially contribute to the onset and progression of these neurodegenerative diseases. https://doi.org/10.1523/JNEUROSCI.0263-25.2026

Thrilled to share our recent review in @sfnjournals.bsky.social ALS and Huntington Disease: Unraveling the Connections between TDP-43 and Huntingtin. Here we discuss links between HD & ALS. Review & cover art come from the multitalented MSc student @cailyncreative.bsky.social tinyurl.com/57y6hjrd

If you want to see our research promoted like it's a sports event go to the 1h13min mark: www.upliftingathletes.org/young-invest... It was really cool to hear our work described this way.

DMartin@drddom.bsky.social · 9mo ago

Incredibly excited to share we're in Philly tonight to fete @firyalrphd.bsky.social who was a 2026 Uplifting Athletes Draft pick supported by Cure VCP Disease Inc. These awards support early career researchers studying rare diseases. Firyal is working developing genetic therapies for VCP disease.

Save the Date for the next @csmb-scbm.bsky.social meeting: Membrane Proteins in Health & Diseases April 8-12, 2026 in beautiful Banff! Looks like there's something for everyone. event.fourwaves.com/2026csmb/pages

✨ The Bernhardt Lab at the University of Guelph is recruiting graduate students for 2026! Join us! We have several fully funded grad positions available ✨ Please spread the word! www.bernhardtlab.org/join-us #CSEE2025

Had the privilege to attend the Satellite meeting for Future Leaders In Canadian Brain Research held by @braincanada.bsky.social Got to hear updates from some amazing early career researchers!

All days should be WFH days according to Ruby. Although she wants more pets and less proofing of manuscripts & grading.

New science couple unlock. Today @drssfs.bsky.social & I had papers accepted! Shaun happens to also be a co-author on the paper from my lab. So, double congrats to her. Also, my paper is my greatest academic albatross. So, I'm pleased to have this out!

The Department of Molecular and Cellular Biology at the University of Guelph is at it again! Continuing our cluster hires with tenure-track Assistant Professor positions in Immunology and Virology (1 position each)! careers.uoguelph.ca/job/Guelph-A... careers.uoguelph.ca/job/Guelph-A...

Hey all you lipid freaks, join me & other lipid obsessed people talk about protein lipidation! If you've never attended, first drink is on me or @pjenkinslab.bsky.social Roles and regulation of protein lipidation in health and disease 27-29 August 2025 Exeter College, Oxford @biochemsoc.bsky.social

Was quite the experience to visit our old postdoc department being on the other side of the lunch table during the career session & having trainees ask us about our career paths. Thanks again to Gareth Thomas for inviting us. @drssfs.bsky.social followed up with an excellent talk of course.

The NeurdyPhagy Lab is in Montreal talking all about palmitoylation in ALS MND. Stop by our posters & say hi. @jesuisyasmeena.bsky.social @cailyncreative.bsky.social

Vacation Ruby. It's been a ruff day (we got scooped on a big story), but Ruby always makes it better (for context, we had charcuterie for dinner & two of those pics are of her trying to go under the table).