Can't believe we just submitted our 6th paper of the year & we're not even done yet. Working on several more we hope to submit soon! And just submitted the proofs for another the 2nd paper. Hope our banner paper year translates into some successful funding apps.

Last week I had the immense honour to take part in the 2026 VCP international Scientific & Community Summit in Atlanta organized by Cure VCP Disease. I felt like when we have the first therapies for this disease, we'll know this is where it started. See all I had to say here: tinyurl.com/37m6phxm

Roche's decision to stop development of two huntingtin-lowering programmes is disappointing, but the story doesn't end there. Years of research have answered some key questions, raised many new ones, and will inform the next generation of HD trials. Read about it here: en.hdbuzz.net/looking-back...

July was a hard month for Huntington’s disease research, with Roche ending two HD programs. But the month also brought promising new tools to visualize and track huntingtin, and important studies on eating and self-awareness in HD. Read the full recap: en.hdbuzz.net/july-2026-th...

We submitted a paper July 2nd & it still doesn't have an editor assigned to it. Pull & resubmit somewhere else?

Hey 🧪! I was just reminiscing with a friend about the time a very senior academic called a mid-career guy's work "completely meaningless" at a meeting and now I want to hear your best (public, academic) disses

Timeline cleanse. Ruby went to daycare today & she's exhausted

I wrote this in a week where it felt like professoring while parenting (and equally, parenting while professoring) was impossible. This feeling ebbs and flows. Seems like Mothers Day is as good a time as any to share, maybe it will help someone else feel less alone. The More Paradox 1/8

I'm having a Darwin Day!

What a weird job somedays. We've published multiple high impact papers recently & are on track for 6-8 papers this year, including new therapeutic strategies in HD & ALS. And yet, all I can think about is how our work isn't worth even discussing at CIHR...

Skyhawk Therapeutics have received the regulatory approval needed to broaden its FALCON-HD trial to include the United States, Canada, and the UK. The expanded trial will enroll up to 400 more people with Stage 2 and early Stage 3 HD across more than 40 sites worldwide.

I strongly disagree with this. Bring back Sam Neill.

Lance Ulanoff@lanceulanoff.com · 3w ago

No. Just no. 😢 Sam Neill, known for 'Jurassic Park' and 'The Piano,' dies at 78, his family says www.npr.org/2026/07/13/n...

Lab of Gisou van der goot @gisouvggoot.bsky.social shows that no less than three palmitoylation enzymes, zDHHC7, zDHHC3 and APT2 are involved in regulating Capillary Morphogenesis Gene 2 (CMG2/ANTXR2). #proteinlipidation #proteinpalmitoylation #zDHHC3 #zDHHC7 #APT2 www.nature.com/articles/s41...

I think I might be ready to run a marathon....slowly. But still.

** if you hold #CIHR funding, you will be required to participate in peer review. …we are reinforcing a clear expectation: Conditions of Funding for Project Grants and other funding opportunities now specify that NPAs who are successful are expected to participate in peer review when invited.

I suspect there's a lot of researchers that need to hear this, especially ECRs, but you are more than your work.

Roche announced it is stopping development of two of its huntingtin-lowering ASO drugs, tominersen and RG6496. This marks a disappointing end to an important chapter in HD clinical research. en.hdbuzz.net/roche-ends-t...

Streamlined again. Really need to kill this grant....

DMartin@drddom.bsky.social · 4w ago

Ugh. Tomorrow is CIHR NOR - Notice of Rejection - day.

Ugh. Tomorrow is CIHR NOR - Notice of Rejection - day.

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program https://www.biorxiv.org/content/10.64898/2026.06.30.735287v1

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program https://www.biorxiv.org/content/10.64898/2026.06.30.735287v1

Excited to share we identified an S-acylation motif & used it to develop a new S-acylation prediction program! @drssfs.bsky.social

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program

S-acylation, the reversible addition of fatty acids to proteins, has emerged as an abundant post-translational modification that drives protein localization and function. With no known consensus seque...

biorxiv.org

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program https://www.biorxiv.org/content/10.64898/2026.06.30.735287v1

Excited to share we identified an S-acylation motif & used it to develop a new S-acylation prediction program! @drssfs.bsky.social

SAPPTree: Identification of an S-Acylation Motif Drives a Novel S-Acylation Prediction Program

S-acylation, the reversible addition of fatty acids to proteins, has emerged as an abundant post-translational modification that drives protein localization and function. With no known consensus seque...

biorxiv.org

The paper is out which means the MD trajectories are finally available! #MolecularNodes #b3d #GeometryNodes

Jan Philipp Kreysing@jpkreysing.bsky.social · last yr.

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

Triple-negative #breast #cancer remains challenging to treat 🩺 New study identifies APT1/LYPLA1-dependent de-S-acylation as a potential therapeutic option, revealing subtype-specific regulation of protein acylation and cell-cycle control #BreastCancer https://ow.ly/xRvt50ZivHo

Should add.... This is the 3/5 papers currently in submission or press for my lab this week. Going to spend more on publishing this year than on student stipends.

DMartin@drddom.bsky.social · last mo.

Ugh. Over $3000 USD to submit a paper for publication. That's about $5k CAD. That's more than my entire publication budget from NSERC...

Ugh. Over $3000 USD to submit a paper for publication. That's about $5k CAD. That's more than my entire publication budget from NSERC...

New preprint from the lab! In this study we dive into the mechanisms that give #leukemia cells #metabolic plasticity, and how it differs from healthy hematopoietic cells. We discovered a process involving rapid changes in protein S-acylation unique to leukemia! www.biorxiv.org/content/10.6...

A Chemical Proteomics Method to Quantify Cysteine S-Acylation | ACS Chemical Biology pubs.acs.org/doi/abs/10.1...

A Chemical Proteomics Method to Quantify Cysteine S-Acylation

S-acylation, often referred to as S-palmitoylation, is a reversible and dynamic posttranslational modification that corresponds to the addition of a long-chain fatty acid to cysteine (Cys) residues. Established mass spectrometry-based chemoproteomics methods have improved our understanding of the S-acylation proteome, notably by identifying hundreds of S-acylated proteins, sometimes with the modified Cys. However, the precise quantification of S-acylation levels for each Cys within a single sample remains challenging at the proteome level. Quantification of S-acylation levels is critical to further our understanding of protein S-acylation in cellular function and its role in health and diseases. We report here the development of an S-acylation quantification workflow based on the sequential labeling of free Cys and S-acylated Cys with isotopic labeling reagents. The workflow was extensively optimized, notably by comparing the number of sites identified with two alkyne-tagged Cys-reactive isotopic probes and four azido-tagged biotin-based capture reagents. By integrating this enhanced workflow with high-field asymmetric waveform ion mobility spectrometry (FAIMS) on LC–MS/MS instruments for the separation of labeled peptides, over 17,000 unique Cys could be quantified in biological samples. Application of the S-acylation quantification workflow to cellular proteomes allowed for the quantification of S-acylation levels in a HeLa proteome. We also identified dynamic S-acylation changes in response to autophagy induction.

pubs.acs.org