A compound called N-oleoyl-leucine (OLE) shows promise as a promoter of Alzheimer's amyloid plaque removal 📷 Victoria Pozzi-Ruiz et al @neuroalc.bsky.social in @springernature.com Cell Death & Disease ➡️ bpod.org.uk/archive/2026... with @rooph.bsky.social

Ectopic expression of PROX1 on endothelial cells underlies blood-brain barrier compromise in brain diseases such as tumours & vascular malformation 📷 Sara González-Hernández et al NIH National Heart, Lung, and Blood Institute in @insight.jci.org ➡️ bpod.org.uk/archive/2026...

Base editing – altering the DNA code with precise targeting – reveals the essential role of the NANOG gene in embryo development 📷 Oliver J Bower et al @niakanlab.bsky.social @cam.ac.uk in @nature.com ➡️ bpod.org.uk/archive/2026... with @rooph.bsky.social

3D super-res microscopy reveals ultrastructure of asymmetric adherens junctions between leader & follower cells in angiogenesis – BIN1 & SNX9 are regulators 📹 Vera Janssen et al University of Amsterdam in @jcb.org ➡️ bpod.org.uk/archive/2026...

Role for non-neuronal cells in memory maintenance – loss of ankyrin-2 protein from the brain's astrocytes impairs recall 📸 Hayoung Kim, Jiwoon Lim & Jooyoung Kim et al Institute for Basic Science (IBS), Daejeon in @natcomms.nature.com ➡️ bpod.org.uk/archive/2026... with @rooph.bsky.social

The rare renin cells of the kidney (here in green) are the organisers of their local nerve/hormone microenvironment 📹 Manako Yamaguchi et al, University of Virginia School of Medicine @insight.jci.org ➡️ bpod.org.uk/archive/2026...

Live 3D imaging of capillaries reveals a blood flow- & permeability-regulating conserved network of Ca2+ signalling-endothelial cells 📹 Anush Swaminathan et al @yaleschoolofmed.bsky.social in @pnas.org ➡️ bpod.org.uk/archive/2026... with John Ankers

Malaria-causing parasite Plasmodium achieves high-fidelity replication throughout its complex life cycle due to proteins SFA1 & SFA2's stabilising role 📸 Buyuan He & Ilzat Ali et al @uniheidelberg.bsky.social & @harvardmed.bsky.social in @embojournal.org ➡️ bpod.org.uk/archive/2026...

Hear, Here: Major cause of deafness the apparently irreversible loss of sensory hair cells can be reversed by NOTCH inhibition 📹 Lama Khalaily et al @karenavraham.bsky.social Tel Aviv University in @science.org Advances 📷 bpod.org.uk/archive/2026... with John Ankers

Theory, simulations & experiments elucidate details of phase separation & pattern formation in a liquid crystal – insights for applications in biomedicine & beyond 📹 Ana Bensabat et al Physics and Astronomy, @edinburgh-uni.bsky.social in @pnas.org ➡️ bpod.org.uk/archive/2026...

Fish eye & skin iridescence is formed by a subtype of lysosome-related organelle (LRO) as found in humans – a study model for LRO-related disorders 📹 Anna Gorelick-Ashkenazi et al @weizmann.ac.il @pnas.org ➡️ bpod.org.uk/archive/2026... + John Ankers

Ear Defenders: Organoids that model inner ear cells' response to ototoxic drugs like gentamicin & cisplatin & how cells might be protected from damage 📷 @amylucassen.bsky.social et al @unileiden.bsky.social in & on cover of @dmmjournal.bsky.social ➡️ bpod.org.uk/archive/2026...

Under Siege: Pyocin antibiotics block bacteria getting vital nutrients via a protein called BAM A without need for the drug to enter the cell 📹 @fabianmunder.bsky.social et al @rhyswg.bsky.social @monashuniversity.bsky.social in @natcomms.nature.com ➡️ bpod.org.uk/archive/2026... with John Ankers

Wrinkliness of giant cancer cells' nuclear lamina is associated with reduced mechano-sensitivity which slows spreading 📷 Samere Abolghasemzade & Ryan Blanchard et al @tamu.bsky.social in @science.org Advances ➡️ bpod.org.uk/archive/2026...

A beautiful image (and study), indeed! A similar image was featured on the Cover of our June issue, Volume 27, issue 12! => link.springer.com/journal/4431...

Biomedical Picture of the Day BPoD@bpodaily.bsky.social · 3w ago

Stn1 protein regulated by the Wnt signalling pathway plays a key role in zebrafish early egg development Image made using @leicamicrosystems.bsky.social microscopy 📷 Xin Zhang, Yanpeng Zhai & Caixia Wang et al Ocean University of China in @emboreports.org ➡️ bpod.org.uk/archive/2026...

Brain Drain: 3D-PAULM combines photoacoustic imaging with ultrasound localisation microscopy => super res images of CSF flow through the glymphatic system 📷 Nanchao Wang & Xinyuan Yu et al @duke-university.bsky.social in @science.org Advances ➡️ bpod.org.uk/archive/2026... + John Ankers

To Boldly Go: Magnetic microrobot system of drug-loaded nanoparticles protected by pH-responsive coating - makes a delivery in pig stomach 📹 Rujie Sun, Junyoung Kim, Yixuan Leng et al @imperialcollegeldn.bsky.social @kavlioxford.bsky.social in @science.org Advances ➡️ bpod.org.uk/archive/2026...

Live Wiring: Active self-organising neuron networks in 'biobots’ grown from frog embryo tissue 📷 Haleh Fotowat et al @drmichaellevin.bsky.social Allen Discovery Center @tufts.edu in Advanced Science ➡️ bpod.org.uk/archive/2026... with @antdlewis.bsky.social

Stn1 protein regulated by the Wnt signalling pathway plays a key role in zebrafish early egg development Image made using @leicamicrosystems.bsky.social microscopy 📷 Xin Zhang, Yanpeng Zhai & Caixia Wang et al Ocean University of China in @emboreports.org ➡️ bpod.org.uk/archive/2026...

Fitness Race: Modelling antibody evolution by replaying a monoclonal germinal centre reaction over a 100 times 📷 William DeWitt, Ashni Vora, Tatsuya Araki et al @victora.bsky.social @rockefeller.edu @matsen.bsky.social in @cp-cell.bsky.social ➡️ bpod.org.uk/archive/2026... + John Ankers

Erythroblastic islands – niches where red blood cells mature – have distinct compositions in mouse & human 📷 Xu Han & Kehan Ren et al @nufeinbergmss.bsky.social in @natureportfolio.nature.com Nature Genetics ➡️ bpod.org.uk/archive/2026...

Heart-on-a-Chip platform with induced pluripotent stem cell-derived heart cells for predictive cardiotoxicity testing 📷 Karine Tadevosyan et al @idibell.bsky.social in Advanced Healthcare Materials ➡️ bpod.org.uk/archive/2026... with @antdlewis.bsky.social

3D imaging & analytic light sheet microscopy pipeline for tracking cancer spread to new sites & revealing malignant cell interaction with vessels there 📷 Sabrina M. Lewis et al @wehi-research.bsky.social in @natureportfolio.nature.com npj Imaging ➡️ bpod.org.uk/archive/2026...

Access Denied: Subtype of influenza A H3N2, but not H1N1, needs transporter protein Rab11B to enter host cells 📷 Allyson H. Turner & Sara A. Jaffrani et al @uvmvermont.bsky.social in @jvico-eics.bsky.social ➡️ bpod.org.uk/archive/2026... with @rooph.bsky.social

Cancer cell entry into lymphatics is driven by balance of TNRC6B/circTNRC6B gene products – possible prognostic marker & treatment target 📷 Lingjiao Meng, Haotian Wu & Jiaxiang Wu et al Fourth Hospital of Hebei Medical University in @cp-cellreports.bsky.social ➡️ bpod.org.uk/archive/2026...

Tiny magnetic pillar platform for studying how cells convert physical forces to biological signals 📷 Roel Kooi et al, @tue.nl in Advanced Healthcare Materials ➡️ bpod.org.uk/archive/2026... with @antdlewis.bsky.social

AXIN1 & AXIN2 regulate WNT-signaling to generate distinct mesodermal cell types in the early embryo 📷 Rocío Hernández-Martínez et al @mskcancercenter.bsky.social in @cp-devcell.bsky.social ➡️ bpod.org.uk/archive/2026...

Seams Vital: Protein called SRSF3 is essential for heart development regulating the formation & function of the epicardium 📷 Irina-Elena Lupu & Susann Bruche et al @ox.ac.uk in @dev-journal.bsky.social ➡️ bpod.org.uk/archive/2026... with @antdlewis.bsky.social

A new dynamic full-field optical coherence microscopy system that dives deep into light-scattering tissues & emerges with high res images 📷 E Tarvydas, A Trečiokaitė & E Auksorius, FTMC Vilnius in @natureportfolio.nature.com npj Imaging ➡️ bpod.org.uk/archive/2026...

BPoD | Deeply Illuminating

Deeply Illuminating - Biomedical pictures for July 2026.

bpod.org.uk

RBM20 regulator of heart muscle protein titin's length itself revealed to have many versions => cardiomyopathy therapy targets 📷 Michael Radke, Victor Badillo Lisakowski & Stefan Meinke et al, @mdc-berlin.bsky.social in @natcomms.nature.com ➡️ bpod.org.uk/archive/2026... with @rooph.bsky.social