Second preprint from the lab. Collab with @dkoveal.bsky.social, with many more to come! Effort led by @xshirleyz.bsky.social with help from Brittany Addison, @ezeyulu00.bsky.social, Claire Deng (on the grad school market, better act fast, Claire’s amazing!), @ajemanuel.bsky.social, and many others!

Our first preprint has been accepted for publication www.science.org/doi/10.1126/... !! tldr: @ezeyulu00.bsky.social , @amartyapradhan.bsky.social , @dkoveal.bsky.social and I developed a method using injectable nanoparticles to turn mice into…constellations in motion. 🧵⤵️

High-resolution in vivo kinematic tracking with customized injectable fluorescent nanoparticles

Injectable fluorescent nanoparticles were used to track positions on and inside of freely moving animals at high resolution.

science.org

This work was driven by the singular vision and dedication of Zeynep Ulutas, @ezeyulu00.bsky.social . We could not have finished this without @amartyapradhan.bsky.social . @dkoveal.bsky.social provided key guidance on chemistry.

Beautiful structural analysis of a lifetime sensor from Rosen et al. Really cool mechanism reveal - something I never would have guessed when we made LiLac. A must-read for sensor folks! www.pnas.org/doi/10.1073/...

a man in a suit and tie is dancing in a room in front of a wall .

ALT: a man in a suit and tie is dancing in a room in front of a wall .

media.tenor.com

How do tiny magnetic fields affect biochemistry? Overflowing with pride over Katherine Xiang's study on a giant magnetic field effect in a red fluorescent protein, www.biorxiv.org/content/10.1...

Mechanism of giant magnetic field effect in fluorescence of mScarlet3, a red fluorescent protein

Several fluorescent proteins, when expressed in E. coli, are sensitive to weak magnetic fields1. We found that mScarlet3 fluorescence in E. coli reversibly decreased by 21% in the presence of a 60 mT ...

biorxiv.org

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Great to see this online as #preprint: TINGL - A Turquoise INdicator for GLucose by the lab of @basteusink.bsky.social (and a small contribution from me): www.biorxiv.org/content/10.1...

Out yesterday in Neuron, the final print version of our paper on voltage imaging with ASAP5, "A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events" www.cell.com/neuron/fullt...

A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events

Hao, Lee, et al. report ASAP5, a GEVI that enhances responsivity and accelerates kinetics. It enables single-trial recordings of sub- and suprathreshold activities in flies, mice, and human stem-cell-...

cell.com