Candie Paulsen Lab
@paulsenlab.bsky.social
Candie Paulsen's biochemistry research group at Yale consisting of unique individuals unified in our use of diverse approaches to study pain signaling.
In a new @natcomms.nature.com study, @yale.edu's @paulsenlab.bsky.social uncovers how the protein calmodulin regulates pain signaling! ⚡ This breakthrough could lead to better pain management strategies 💊 Read More 👇 news.yale.edu/2025/09/30/u...
Unraveling a painful mystery: Protein plays key role in modulating pain response
A new Yale study has uncovered the hidden mechanical move that may regulate pain signaling in the human body — and why it sometimes goes awry.
news.yale.edu
🧠Pain sensors need to switch on fast—and off just as quickly. In our new tour de force Nat Comms paper - led by the first Paulsen lab grad student - we show that calmodulin plays a key role in shutting down the TRPA1 pain receptor - a finding that could guide new pain therapies. 📰 rdcu.be/eJcMK
Calmodulin binding is required for calcium mediated TRPA1 desensitization
Nature Communications - For pain signaling to be useful, sensory receptors must rapidly detect noxious stimuli and efficiently turn off once the threat has passed. Here, the authors uncover a...
rdcu.be
We had a great time at BPS 2025– learned a lot and made great connections. Congrats to Paulsen Lab grad student Isabel Romov for winning a Student Research Achievement Award! We celebrated at Disneyland. ‘Til next year!
Suffragists famously wore white as a symbol of purity, morality, and the quest for equality. My sartorial decision to wear (mostly) white at #BPS2025 was meant as a reminder of the ongoing fight for gender equality and the importance of continued advocacy for women’s rights. #womeninscience
We are delighted to share the next story from the Paulsen lab! In a team effort led by Candie's first Yale grad student, Justin Sanders, we've uncovered a critical role for calmodulin in the TRPA1 pain receptor's calcium regulation. Check it out here: www.biorxiv.org/content/10.1...
