Yale Neuroscience

@yaleneuro.bsky.social

Yale Department of Neuroscience https://medicine.yale.edu/neuroscience/

The Strittmatter, Song (@ericsongg.bsky.social), and Zhang labs are studying how misfolded alpha-synuclein—a protein associated with Parkinson’s disease—moves between neurons and is cleared from the brain. Their work could reveal new ways to limit its spread.

Managing Misfolded Proteins to Prevent Parkinson’s Disease

A Yale-led team aims to prevent the spread and increase clearance of misfolded proteins in the brain associated with Parkinson's disease.

medicine.yale.edu

Congratulations to Aaron Kuan (@kuanawanda.bsky.social), assist prof of Neuroscience, for being awarded a NIH Director’s New Innovator Award: "We design systems that will make it possible to map the entire brain and study the individual connections between neurons."

Kuan Wins NIH New Innovator Award to Map Brain Connections

Aaron Kuan, PhD, professor of neuroscience, wins NIH award and funding to map brain connections with electron microscopy.

medicine.yale.edu

Researchers in the Gracheva @yaleneuro.bsky.social and Bagriantsev labs found that hibernating squirrel mechanosensory neurons—which convert touch sensation into electrical signals—are adapted to survive in low temperatures and retain their signaling capabilities.

How Hibernating Squirrels Retain Sense of Touch in the Cold

Mechanosensory neurons in ground squirrels retain their signaling abilities despite prolonged exposure to cold temperatures.

medicine.yale.edu

Two new articles from the Reinisch lab @yalecellbiology.bsky.social and De Camilli lab @yaleneuro.bsky.social provide the first complete molecular characterization of VPS13A and C, two proteins involved in neurodegenerative diseases, and show that they can exist in active and inactive states.

New Insights into Proteins Linked to Neurodegeneration

Mutations in VPS13 proteins are associated with neurodegenerative conditions like Parkinson’s disease. New findings could point to therapeutic avenues.

medicine.yale.edu

Congratulations to Amy Arnsten, Albert E. Kent Professor of Neuroscience, for being awarded the Peter Seeburg Integrative Neuroscience Prize. She was honored for her foundational work in understanding the distinctive molecular, cellular, & circuit mechanisms that underlie executive brain functions.

Arnsten Awarded Peter Seeburg Integrative Neuroscience Prize

Amy Arnsten, PhD, Albert E. Kent professor of Neuroscience, received the 2026 Peter Seeburg Integrative Neuroscience Prize, awarded by the Schaller-Nikolich

medicine.yale.edu

A new role for the "little brain" of the heart: a team of researchers led by @yaleneuro.bsky.social graduate student Qian Xu & associate professor Rui Chang identified two types of cardiac neurons, essential for heart function and resilience under stress. 🫀🧠

The intrinsic cardiac nervous system is essential for cardiac function and survival

The intrinsic cardiac nervous system (ICNS) is a key node in heart-brain communication and an emerging target for cardiac therapy, yet its physiologic…

sciencedirect.com

Your organs aren't just following orders from the brain. A new Yale study finds they build their own nervous systems and talk back, with heart tissue even able to reprogram gut neurons to act like heart cells. Read more: bit.ly/4aD8qYd

Rui Chang, I-Uen “Yvonne” Hsu, and Le Zhang in a lab setting.Mouse embryos stained with nerves (green) and organ intrinsic neuron markers (red).

Photos by I-Uen “Yvonne” Hsu, first author of the study.Mouse heart, showing intrinsic cardiac neurons.

Photo by I-Uen “Yvonne” Hsu

New paper from @limlabyale.bsky.social: first author Changwoo (Chris) Lee and lab members show that neurons are not the whole story in ataxia: oligodendrocytes contribute to the development of the disease.

Journal of Clinical Investigation@jci.org · 4mo ago

SCA1 is a neurodegenerative disease driven by polyQ expansion in ATXN1 doi.org/10.1172/JCI1... @limlabyale.bsky.social & team provide strong evidence on the role of oligodendrocyte-specific expression of pathogenic ATXN1 in neuronal malfunction and systemic dysfunction in mouse models.

A team of graduate students in neuroscience welcomed local New Haven middle schoolers for Brain Education Day🧠. From brain imaging to sensory physiology, the young students participated in fun activities to explore the wonders of the nervous system.

Engaging Local Middle Schoolers at Brain Education Day 2026

On March 29, 2026, 60 Yale scientists came together to orchestrate activities around the brain for about 90 middle school students from the greater New Haven

medicine.yale.edu

A new @nature.com study from Rui Chang's lab uses lineage tracing, 3D imaging, single-cell transcriptomics, and genetic perturbations to show how organ-specific neural circuits are formed. They reveal that organs help shape their own nervous systems.

Beyond the brain: Organs help shape the nervous systems that control them

A new Yale study finds that organs help direct the development of their own nervous systems, creating specialized networks that enable a two-way conversation between body and brain.

news.yale.edu