We are delighted to welcome Dr Mauro Cives and Prof. Longfei Liu to the Endocrine-Related Cancer Editorial Board as Associate Editors. Their extensive expertise across endocrine cancer research will be a valuable addition to our Editorial Board. Please join us in welcoming them!

A new review by Madson Q. Almeida, Patricia L. M. Dahia, and Mercedes Robledo summarizes advances in PPGL genomics, including geographic and sex-related particularities. 🔗 doi.org/10.1530/ERC-26-0258

A new review examines evidence on succinate dehydrogenase (SDH) germline mutation carriers, exploring the inheritance and penetrance of SDHx pathogenic variants, cellular adaptations linked to haploinsufficiency, and environmental influences on disease onset. 🔗 doi.org/10.1530/ERC-26-0282

A new review examines the current management of aggressive PitNETs, highlighting evidence gaps, emerging molecular insights, and several priorities that should shape the future research agenda. 🔗 doi.org/10.1530/ERC-25-0502 This paper forms part of the WorldMEN 2025 Special Collection.

A new study by Emma Boehm et al. explores the highly variable responses to PRRT in pancreatic neuroendocrine tumours (PNETs). Using whole genome or exome sequencing of 40 PNET samples, the study examines the genomic features associated with PRRT response. 🔗 doi.org/10.1530/ERC-26-0207

Peptide receptor radionuclide therapy (PRRT) is a promising targeted treatment for aggressive pituitary neuroendocrine tumours (PitNETs). Francesco Ferraù et al. review current evidence on the efficacy and safety of PRRT in this setting. 🔗Read the review: doi.org/10.1530/ERC-26-0109

A new review by Yair Schwarz, Reut Halperin and Amit Tirosh examines the significant progress in the molecular characterization of PitNETs, which has advanced understanding of the molecular pathways driving tumour initiation and progression. 🔗 Read the review: doi.org/10.1530/ERC-26-0213

What impact does ageing have on parathyroid disease? A new review explores parathyroid adenoma and carcinoma in older adults, highlighting evidence gaps and the need for larger studies to improve patient care. Read the review: doi.org/10.1530/ERC-26-0203

New Associate Editor joins our Editorial Board We are delighted to welcome Professor Svenja Nölting, an internationally recognised expert in pheochromocytomas, paragangliomas and neuroendocrine tumours, to the Endocrine-Related Cancer Editorial Board as an Associate Editor.

Can AI improve decision-making across the pituitary patient pathway? A new review by George Hudson et al. examines the latest advances in AI algorithms and the potential applications of AI across pre-, intra- and post-operative stages of pituitary care. #OpenAccess 🔗 doi.org/10.1530/ERC-26-0104

What are the metabolic determinants underlying lineage-specific characteristics in pituitary neuroendocrine tumors (PitNETs)? A new study demonstrates that TF-defined PitNET lineages exhibit distinct intratumoral steroid metabolite profiles. 🔗 doi.org/10.1530/ERC-26-0154

We are delighted to welcome Assistant Prof. Jung Hee Kim to the Endocrine-Related Cancer Editorial Board as an Associate Editor. A leading expert in pituitary and adrenal tumours, Jung's appointment further strengthens our editorial expertise in these important areas of endocrine cancer research.

In a new review, Stephen Ludgate et al. examine the current state and future directions of functional imaging approaches across major hereditary syndromes, including MEN types 1–4, von Hippel–Lindau disease & hereditary paraganglioma–phaeochromocytoma syndromes. 🔗 doi.org/10.1530/ERC-25-0516

Endocrine-Related Cancer is seeking a Deputy Editor to join its expert Editorial Board. This is an opportunity to help shape the journal’s direction & contribute to advancing research in the field of endocrine oncology. Learn more: journals.bioscientifica.com/erc/pages/vacancies

In a new retrospective cohort study, hormone-secreting lung-NENs were associated with shorter overall survival than non-secreting lung-NENs, with multiple hormone secretion identified as an independent negative prognostic factor. 🔗 Read the full research #OpenAccess: doi.org/10.1530/ERC-26-0142

Emerging Leader Spotlight: Dr Rayzel Fernandes @imperialcollegeldn.bsky.social A 2026 Endocrine-Related Cancer Emerging Leader, Dr Fernandes' latest review examines factors driving AR cistrome reprogramming in prostate cancer progression & its potential clinical utility. 🔗 doi.org/10.1530/ERC-...

New research by Malin Hagberg Thulin et al. highlights the critical role of adrenal-dependent androgen synthesis in driving the sclerotic castration-resistant prostate cancer (CRPC) within the bone microenvironment. Read the research: doi.org/10.1530/ERC-...

Happy to see our new review paper led by @jameskcl.bsky.social . We discuss evidence on the role of stem cells in pituitary tumours. Furthermore, we discuss practical criteria for identifying stem cells, and develop a framework for their possible contributions to tumours. @pituitarylab.bsky.social

Endocrine-Related Cancer@endocancer.bsky.social · 3mo ago

🧠 What role do stem cells play in pituitary tumour formation and progression? A new review examines the current evidence implicating pituitary stem cells and tumour stem-like populations in pituitary tumour biology. 🔗 Read the review: doi.org/10.1530/ERC-26-0171

🧠 What role do stem cells play in pituitary tumour formation and progression? A new review examines the current evidence implicating pituitary stem cells and tumour stem-like populations in pituitary tumour biology. 🔗 Read the review: doi.org/10.1530/ERC-26-0171

We’re pleased to spotlight Johannes Hofland, an Endocrine-Related Cancer Emerging Leader, & co-author on: Gut microbial and functional alterations lead to metagenomic signatures for midgut neuroendocrine tumor patients and for carcinoid syndrome 🔗 Read the article: doi.org/10.1530/ERC-24-0145

New research by Yasmine Kemkem et al. provides the first functional evidence suggesting that SOX2+ cells in phaeochromocytomas (PCCs) and paragangliomas (PGLs), collectively known as PPGLs, possess the potential to serve as tumour cells of origin. Read the full research: doi.org/10.1530/ERC-...

We’re pleased to spotlight Katherine Wolf, an Endocrine-Related Cancer Emerging Leader, and author on a new paper exploring an important question: could adrenocortical carcinoma (ACC) be associated with Birt–Hogg–Dubé syndrome (BHDS)? 🔗 Read the article: doi.org/10.1530/ERC-...

How do EVs from obese adipose tissue drive malignancy in breast cancer? New research investigates the effects of obese AT-derived EVs on MCF‑7 cells by analysing the changes in cellular functions, epithelial marker expression, and signaling pathways. 🔗 doi.org/10.1530/ERC-...

A new review by K. Mansukhbhai Shekhda et al. evaluates the effects of NET therapies, including somatostatin analogues, molecular targeted therapy, peptide receptor radionuclide therapy and chemotherapy, on reproductive and sexual function in patients with NETs. 🔗 doi.org/10.1530/ERC-25-0500

In a new review, Borbála Szabó, Attila Patocs & Henriett Butz examine DNA methylation–demethylation cycle in PitNETs, highlight challenges of detecting cytosine modifications & outline emerging evidence linking altered demethylation to tumour biology. 🔗 doi.org/10.1530/ERC-26-0030

A new mini review by Mia Zol‑Hanlon and Neil Q. McDonald explores progress in defining RET receptor architecture & discusses current models for how distinct assemblies of GFL–GFRα–RET receptor complexes activate intrinsic RET tyrosine kinase to relay signals. 🔗 doi.org/10.1530/ERC-25-0322

🎉 Congratulations to Associate Professor Matti Gild, winner of the Emerging Leader Best Paper Award 2025 for her outstanding contribution to the field with the paper: “Evaluating the prognostic potential of circulating cell‑free DNA in advanced thyroid cancer” 🔗 doi.org/10.1530/ERC-24-0227

Amongst the many cool things, we: - characterised SOX2+ expressing cells across PPGLs - identified expression signatures associated with metastatic potential - identified changes in expression between SOX2+ high versus SOX2+ low samples The paper is now out in @endocancer.bsky.social

I’m really glad to have been a part of this exciting project studying rare neuroendocrine tumours called phaeochromocytomas and paragangliomas. We performed 10x Genomics single-cell/nucleus RNA-seq on 7 PPGL patients, and integrated published data from another 12 patients. doi.org/10.1530/ERC-...

New research by Akitada Yogo et al. characterises microscopic small‑intestinal neuroendocrine tumorlets (SINTs) found in multifocal SI‑NETs, assessing their clinicopathological features and possible roles in multifocal tumorigenesis. 🔗 Read the research: doi.org/10.1530/ERC-25-0425