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Endocrine-Related Cancer

@endocancer.bsky.social

Publishing translational & clinical investigations of human health & disease focusing on #endocrine neoplasias & hormone-dependent #cancers. Owned by Society of Endocrinology.

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Endocrine-Related Cancer@endocancer.bsky.social · last wk.

We are delighted to welcome Assistant Prof. Jung Hee Kim to the Endocrine-Related Cancer Editorial Board as an Associate Editor. A leading expert in pituitary and adrenal tumours, Jung's appointment further strengthens our editorial expertise in these important areas of endocrine cancer research.

Endocrine-Related Cancer logo. New Associate Editor. We are delighted to welcome Professor Jung Hee Kim MD PhD. Professor of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Republic of Korea. 80 Years 1946-2026 Society for Endocrinology logo.
Bence Kövér@bencekover.bsky.social · last mo.

Happy to see our new review paper led by @jameskcl.bsky.social . We discuss evidence on the role of stem cells in pituitary tumours. Furthermore, we discuss practical criteria for identifying stem cells, and develop a framework for their possible contributions to tumours. @pituitarylab.bsky.social

Endocrine-Related Cancer@endocancer.bsky.social · last mo.

🧠 What role do stem cells play in pituitary tumour formation and progression? A new review examines the current evidence implicating pituitary stem cells and tumour stem-like populations in pituitary tumour biology. 🔗 Read the review: doi.org/10.1530/ERC-26-0171

Endocrine-Related Cancer logo. Open Access logo. The role of stem cells in pituitary tumour formation. By James Kaufman-Cook, Bence Kövér, and Cynthia L Andoniadou. Figure 3. Stem cell models of pituitary tumourigenesis. Schematic illustrating the potential roles of PSCs and TSC-like cells in tumour formation. Under oncogenic stimuli, stem cells can drive tumourigenesis through cell-autonomous mechanisms by proliferating rapidly, differentiating and directly giving rise to tumours, in a classic cancer stem cell (CSC) paradigm (purple box). Thus far, this has been demonstrated in SOX2+ cells harbouring mutations in BRAFV600E in human PCP. Tumourigenesis can also occur via non-cell-autonomous mechanisms (yellow box), where paracrine signals or a senescence-associated secretory phenotype from a transformed tumour-initiating cell (TIC) promotes proliferation and/or transformation of other cells into TSCs or TSC-like cells. Thus far, this has been demonstrated only in ACP. Whether TSC-like cells contribute to tumourigenesis through either cell-autonomous or non-cell-autonomous mechanisms in pituitary neuroendocrine tumours (PitNETs) remains to be determined. PSCs exposed to oncogenic stimuli that become lineage-committed may retain stem-like characteristics, marker expression or proliferative potential, contributing to tumour formation as TSCs. Conversely, and still unconfirmed, committed endocrine cells may undergo de-differentiation in response to oncogenic signals, acquiring stem-like properties and promoting tumourigenesis through either cell-autonomous or non-cell-autonomous pathways, as TSCs. These populations may also influence tumour progression by modulating the tumour microenvironment. Finally, healthy PSCs may become trapped within the expanding tumour mass and contribute to tumour maintenance or progression through... Endocrine-Related Cancer 33, 6; 10.1530/ERC-26-0171. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.