Juleen R. Zierath
@juleenrzierath.bsky.social
Professor of Physiology at Karolinska Institutet - SRP Diabetes & University of Copenhagen - Center for Basic Metabolic Research. Lifelong Athlete. Member of Nobel Assembly, Royal Swedish Academy of Sciences, Keystone Symposia Board, & Past President EASD.
Our latest at Molecular Metabolism - a Clock/Ampk connection! The Circadian Clock Component NPAS2 is modulated by AMPK and Regulates Substrate Utilization and Mitochondrial Function in Human Skeletal Muscle. Great collaboration w/team @cbmr.science @ki.se www.sciencedirect.com/science/arti...
sciencedirect.com
It is soon time to announce the Nobel Prizes in Physiology or Medicine, Physics, Chemistry, Literature, Peace and Economic Sciences. Announcements will take place on Oct 5-12. Stay tuned! In the meantime, here are some thoughts on what it takes to receive a Nobel Prize youtube.com/watch?v=wfHf...
What does it take to get a Nobel Prize?
YouTube video by Nobel Prize
youtube.com
Postdoc in Therapeutic Potential of Urocortin II to Protect Muscle Mass and Function The University of Copenhagen is seeking a highly motivated and talented Postdoctoral Fellow! Join Us! @cbmr.science employment.ku.dk/faculty/?sho...
Postdoc in Therapeutic Potential of Urocortin II to Protect Muscle Mass and Function
employment.ku.dk
Exercise timing and circadian regulation of metabolism in type 2 diabetes. Our latest review: Exercise modulates our biological rhythms, with timing emerging as an important factor for metabolic outcomes in type 2 diabetes. www.sciencedirect.com/science/arti...
Exercise timing and circadian regulation of metabolism in type 2 diabetes
The circadian system regulates daily rhythms in metabolism and hormone secretion; however, in type 2 diabetes, disrupted clock gene oscillations in sk…
sciencedirect.com
Looking forward the 2025 Nobel Lectures in Physiology or Medicine today at Karolinska Institutet Congratulations to the Laureates Professor Shimon Sakaguchi Dr Mary E. Brunkow Dr Fred Ramsdel For info on the lectures see link: news.ki.se/calendar/the...
New results from @nicopillon.bsky.social and team Human development and gender inequality are associated with cardiorespiratory fitness: A global systematic review of V̇O2peak. news.ki.se/gender-equal... www.sciencedirect.com/science/arti...
Human development and gender inequality are associated with cardiorespiratory fitness: A global systematic review of V̇O2peak
Cardiorespiratory fitness (CRF) is a powerful predictor of mortality and chronic disease risk, yet global patterns and determinants of CRF remain poor…
sciencedirect.com
Great visit to Novo Nordisk Foundation Center for Genomic Mechanisms of Disease in Boston at Broad Institute. Delighted to see great collaborations with Novo Nordisk Foundation Center for Basic Metabolic Research @cbmr.science @novo-nordisk.bsky.social
Not too late to register for Keystone Symposia meetings- great networking opportunities: Obesity Therapeutics: Unlocking Benefits & Minimizing Side Effects keystonesymposia.org/conferences/... Cardiometabolism in Health & Disease keystonesymposia.org/conferences/... Keystone Resort, Jan 26–29, 2026
Obesity Therapeutics: Unlocking Benefits and Minimizing Side Effects | Keystone Symposia
Join us at the Keystone Symposia on Obesity Therapeutics: Unlocking Benefits and Minimizing Side Effects, January 2026, in Keystone, with field leaders!
keystonesymposia.org
Celebrating the 60th Anniversary of @diabetologiajnl.bsky.social Diabetologia - the flagship journal of @easdnews.bsky.social the European Association for the Study of Diabetes! Thanks to our colleagues at the American Diabetes Association and Diabetes Care AND it’s editor-in-chief - Steve Kahn
The Zierath/Krook/Wallberg lab celebrated our current & former fellows & students at Nobel Forum with a fantastic symposium on insulin action & metabolism. Grateful for all who traveled far & near to be with us to focus on science, inclusion, and innovation! photographer: Stefan Zimmerman
The Zierath/Krook/Wallberg lab celebrated our current & former fellows and students at Nobel Forum sept 1 with a fantastic symposium on insulin action & metabolism. Grateful for all the trainees who traveled far & near to be with us to focus on science, inclusion, and innovation!
Visited family this past weekend and one of my siblings has this posted in the front yard! I completely agree with each and every point! Happy summer!
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks. www.nature.com/articles/s42...
Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic...
nature.com
Congratulations team! 👍 This will be of interest for muscle physiologists #MyoBlue @myoblue.bsky.social
Anna Krook@annakrook.bsky.social · last yr.A human specific lncRNA important for ribosomal biogenesis in skeletal muscle- reduced in people with type 2 diabetes.Latest from the team! @ilkesen.bsky.social @juleenrzierath.bsky.social Science Advances www.science.org/doi/10.1126/...
Our latest: HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise. Great teamwork w/ Amy Ehrlich, Kirstin MacGregor & Ste Ashcroft at al! #MyoBlue @myoblue.bsky.social www.pnas.org/doi/10.1073/...
HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise | PNAS
The regulation of metabolism in peripheral tissues is intricately linked to circadian rhythms, with hypoxia-inducible factor-1α (HIF1α) implicated ...
pnas.org
Our latest study connects reduced NR4A3 expression with physical inactivity and indicates that NR4A3 downregulation in human muscle has adverse effects on glucose metabolism and protein synthesis. Congrats to Jon Smith Brendan Gabriel Nico Pillon & team! www.sciencedirect.com/science/arti...
Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: insights from in vitro analysis
Physical activity promotes health, whereas inactivity is associated with metabolic impairment. The transcription factor nuclear receptor subfamily 4 g…
sciencedirect.com
Our latest! Great team effort! We found that in men & women with type 2 diabetes, afternoon high-intensity interval exercise appears to be more effective than morning high-intensity interval exercise for maintaining glucose management. @diabetologiajnl.bsky.social link.springer.com/10.1007/s001...
Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes - Diabetologia
Aims/hypothesis The aim of this study was to investigate effects of time of day on glucose management in individuals with type 2 diabetes undertaking high-intensity interval exercise. Additionally, th...
link.springer.com
Attending Keystone Symposia Board of Directors meeting @keystonesymposia.bsky.social planning for future programs & initiatives. Keystone Symposia serves as a catalyst for the advancement of biomedical & life sciences by connecting scientists within & across disciplines at conferences & workshops
Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science www.sciencedirect.com/science/arti...
Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…
sciencedirect.com
Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise- New study by Paola Pinto-Hernandez reveals training-induced molecular mediators in the response and adaptation to training. www.sciencedirect.com/science/arti...
Training-induced plasma miR-29a-3p is secreted by skeletal muscle and contributes to metabolic adaptations to resistance exercise in mice
It remains unclear whether the adaptive response to different exercise models is mediated by extracellular vesicle (EV) microRNAs (miRNAs) released fr…
sciencedirect.com
Highlighting our latest research. Deconvoluting insulin signaling in human skeletal muscle. www.news-medical.net/news/2025052...
Scientists discover unique molecular fingerprints of insulin resistance
Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes.
news-medical.net
Personalized molecular signatures of insulin resistance and type 2 diabetes. Great collaboration with @annakrook.bsky.social and @adeshmukh.bsky.social A comprehensive clinically focused study of insulin signaling in skeletal muscle. 💪 Online today! www.sciencedirect.com/science?_ob=...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
sciencedirect.com
Delighted to attend Genomic Mechanisms of Disease conference! The 31st Science Cluster conference, "Genomic Mechanisms of Disease" brings together experts to discuss research on the genomic influences underlying various diseases. Thx to novonordiskfonden.dk/en/projects/... @novo-nordisk.bsky.social
Latest from Jonas Treebak and team @cbmr.science NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…
sciencedirect.com
Our latest! Great collaborative effort with David Rizo-Roca & John Henderson! Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes - Journal of Internal Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
<em>Journal of Internal Medicine</em> | Wiley Online Library
Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification of metabolites that a...
onlinelibrary.wiley.com
Congratulations to Mikael Ryden @ki.se @srpdiabetes.bsky.social Looking forward to this lecture!!
European Association for the Study of Diabetes@easdnews.bsky.social · last yr.🏆It is with great honour that we announce Prof. Mikael Rydén as the recipient of the 40th EASD Camillo Golgi Prize, recognising his groundbreaking work in adipose tissue biology and diabetes complications. Congratulations, Prof. Rydén!👏 This prize is generously supported by Novo Nordisk.
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism Great collaboration led by Satchin Panda and team! Happy to contribute. Time to take timing into consideration!! www.nature.com/articles/s42...
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
nature.com
If you missed Metabolism Day #MD25, @cbmr.science you can catch the talks here! m.youtube.com/watch?v=oUi9...
Metabolism Day 2025
YouTube video by CBMR at the University of Copenhagen
m.youtube.com
Just wrapping up this Nobel Prize Dislogue Tokyo on the “Future of Life” @nobelprize.bsky.social Very interesting discussions about opportunities and challenges for all to consider #NobelPrize catch up on the program online More info here: www.nobelprize.org/events/nobel...
