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Ozvan Bocher

@ozvanbocher.bsky.social

Assitant Professor | Université de Bretagne Occidentale | Statistical Genetics | Multi-omics analyses

16 Posts52 Follower80 Folgt
Nature Metabolism@natmetabolism.nature.com · 5mo ago

RESEARCH | @ozvanbocher.bsky.social E Zeggini (U Brest, Helmholtz Munich) et al. The causal links of gene expression and protein abundance on type 2 diabetes risk in 4 ancestries 🧪

Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues - Nature Metabolism

Analysing the causal links of gene expression and protein abundance on type 2 diabetes risk in blood and seven tissues related to the disease from individuals of four ancestries, the authors advance our understanding of the genetic architecture of type 2 diabetes

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Ozvan Bocher@ozvanbocher.bsky.social · 7mo ago

Very proud and happy to share the publication of our study in Nature Metabolism, where we decipher causal molecular mechanisms underlying Type 2 Diabetes 🥳🧬 Key insights from the study highlighted in the Research Briefing: www.nature.com/articles/s42... Full study: www.nature.com/articles/s42...

Identifying genes and proteins with causal effects on type 2 diabetes risk across tissues and populations - Nature Metabolism

Using tissue- and ancestry-aware causal inference analyses, we identified 923 genes and 46 proteins whose expression levels causally influence type 2 diabetes risk. Tissue-related heterogeneity was hi...

nature.com

Ozvan Bocher@ozvanbocher.bsky.social · last yr.

Our study on causal molecular mechanisms leading to T2D is out as a preprint ! We highlight genes and proteins with putative causal effects, mostly shared across ancestries but with high tissue-related heterogeneity, offering targets for prioritization in future T2D research.

medRxivpreprint@medrxivpreprint.bsky.social · last yr.

Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues https://www.medrxiv.org/content/10.1101/2025.05.05.25326880v1

Ozvan Bocher@ozvanbocher.bsky.social · last yr.

New paper out! Impact of dietary restriction of animal products on molecular profiles, most of which are positive for health. Our findings can inform drug development in a food-as-medicine approach. Huge thanks to everyone involved and to the study's participants! www.nature.com/articles/s44...

Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health - npj Metabolic Health and Disease

npj Metabolic Health and Disease - Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health

nature.com

Ozvan Bocher@ozvanbocher.bsky.social · 4y ago

So proud to have received an award for my PhD from #FondationUBO. Thank you again to @UBO_UnivBrest and to my supervisors @GeninEmmanuelle, @HydrePrever and @JF2leuze. It has been an incredible adventure that I am delighted to pursue now at @HelmholtzMunich with @EleZeggini

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Ozvan Bocher@ozvanbocher.bsky.social · 4y ago

Do you want to perform rare variants analysis in the whole genome and go beyond the genes ? Try out RAVA-FIRST, now published in @PLOSGenetics ! x.com/OzvanBocher/st… journals.plos.org/plosgenetics/a…

Ozvan Bocher@ozvanbocher.bsky.social · 5y ago

RAVA-FIRST: our new strategy to study rare variants in the coding and the non-coding genome. Freely available in the R package Ravages. @GeninEmmanuelle @HydrePrever @TregouetBPH @JF2leuze x.com/biorxivpreprin…

Ozvan Bocher@ozvanbocher.bsky.social · 5y ago

Very proud to have defended my PhD thesis yesterday at @UBO_UnivBrest. Many thanks to @GeninEmmanuelle, @HydrePrever and @JF2leuze for those three years and looking forward to start a new adventure in Munich with @EleZeggini team !

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