I'm excited to announce that I launched my lab in May at the Bio-X Institute, Shanghai Jiao Tong University. Our research focuses on myelin–axon pathology and its interplay with neuron–glia–vascular interactions in neurodegeneration. Visit our lab page via the QR code or at www.yifeicai.com

“I met Yifei Cai during the opening keynote by Dana Pe’er; we happened to sit next to each other and immediately connected over how exciting the talk was”. And that’s how our beautiful (and wonderfully productive) collaboration got started!

EMBL-EBI@ebi.embl.org · last yr.

A poster, a conversation, and a cross-Atlantic collaboration where bioinformatics meets neuroscience to uncover new insights into Alzheimer’s disease 🌍🧠 www.ebi.ac.uk/about/news/t... #Alzheimers 🖥️🧬

In our most recent paper, we uncover the myelin-axon interactome in human brains and reveal molecular perturbations and structural disruptions at the myelin-axon interface in Alzheimer’s disease @jgrutzendler.bsky.social @epetsalaki.bsky.social @reimand.bsky.social www.nature.com/articles/s41...

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience

In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...

nature.com

Excited to share that two studies from my postdoc research were published back to back! In the first, we uncovered the molecular basis of axon spheroids—a key hallmark of Alzheimer's disease—and demonstrated their potential reversibility. www.nature.com/articles/s43...

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease - Nature Aging

Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to...

nature.com

Happy to share our latest study, led by @YifeiCai_. We applied Antibody-Driven Proximity Labeling to analyze postmortem human brain tissue, mapping the molecular architecture of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease. 🔗 Read here: www.nature.com/articles/s43...

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease - Nature Aging

Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to...

nature.com

Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...