Jaime Grutzendler
@jgrutzendler.bsky.social
Neuroscientist and Neurologist @Yale / Neurodegeneration / In vivo imaging / Neuro-Glial-Vascular Biology / Translational Neuroscience https://medicine.yale.edu/lab/grutzendler/
Truly beautiful myelin imaging Bobby, Congrats!!
Robert Hill@bobalhill.bsky.social · last yr.We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy. www.nature.com/articles/s44...
At the myelin-axon interface, axon-glial signaling, paranodal architecture, and β-amyloid aggregation are altered in Alzheimer's disease, implicating myelin-axon disruption in disease progression @jgrutzendler.bsky.social @yifeicai.bsky.social www.nature.com/articles/s41...
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience
In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...
nature.com
very appreciative of this collaboration!! @reimand.bsky.social
Jüri Reimand@reimand.bsky.social · last yr.Very happy to have contributed to this comprehensive study on myelin–axon interface vulnerability in Alzheimer’s disease by @yifeicai.bsky.social @jgrutzendler.bsky.social. @mslob95 led our integrative pathway analyses. All started from a brief posterside chat at CSHL www.nature.com/articles/s41...
Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...
Happy to share our latest study, led by @YifeiCai_. We applied Antibody-Driven Proximity Labeling to analyze postmortem human brain tissue, mapping the molecular architecture of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease. 🔗 Read here: www.nature.com/articles/s43...
Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease - Nature Aging
Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to...
nature.com
www.science.org/doi/10.1126/...
A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution
To fully understand how the human brain works, knowledge of its structure at high resolution is needed. Presented here is a computationally intensive reconstruction of the ultrastructure of a cubic mi...
science.org
Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls
🧪Thanks to @rbaltman.bsky.social for having me on The Future of Everything podcast to talk about treatments for Alzheimer's disease. Give a listen if you're interested in an (anti)anti-amyloid antibody argument and some promising new drug targets. #Alzheimers engineering.stanford.edu/news/future-...
The future of Alzheimer's treatment
A neurologist who studies Alzheimer’s disease says hopes are on the rise for new treatments that target tau proteins.
engineering.stanford.edu
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵
Neuroscience methods - YouTube
Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...
youtube.com
likewise, happy to have contributed to the comprehensive update on this important topic
Gabor Petzold@gaborpetzold.bsky.social · 2y agoToo many authors to list here, but very happy to have contributed to this review led by Michael Heneka on #neuroinflammation in #Alzheimer‘s disease, now out in @natrevimmunol.bsky.social. @dzne.bsky.social www.nature.com/articles/s41...
I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.
What a great initiative! 👉 Highlighting an outstanding paper by another researcher. 👉 Below is a must-read by @jgrutzendler.bsky.social and team 👇 www.science.org/doi/full/10....
Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo
Astrocytes and microglia have specialized roles and display a coordinated response during corpse removal in the live brain.
science.org
Altmetric@altmetric.com · 2y agoWhat’s so wonderful about these posts is watching researchers explaining why the work of other people is awesome.
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
elegant paper from Robert Hill’s lab www.biorxiv.org/content/10.1...
Transient upregulation of procaspase-3 during oligodendrocyte fate decisions
Oligodendrocytes are generated throughout life and in neurodegenerative conditions from brain resident oligodendrocyte precursor cells (OPCs). The transition from OPC to oligodendrocyte involves a com...
biorxiv.org
www.nature.com/articles/s41...
Super-resolution imaging of fast morphological dynamics of neurons in behaving animals - Nature Methods
A variant of structured illumination microscopy called MLS-SIM allows super-resolution imaging of neuronal structures such as spinules, spines and boutons in awake mice.
nature.com
interesting paper www.nature.com/articles/s41...
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits - Nature Methods
PdCO is a switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo, as demonstrated in a variety of contexts mainly in the mouse.
nature.com