Integrated signatures define mutational processes in prostate cancer - Nature

Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

nature.com

biorxiv.org

Early Career or Mid-Career Principal Investigator

About OICR   OICR is Ontario’s cancer research institute. We bring together people from across the province and around the world to improve the lives of everyone affected by cancer. We take on the big...

oicr.bamboohr.com

Tumour promotion through the lens of evolution - Nature

This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environment...

nature.com

doi.org

doi.org

Ancestry and somatic profile indicate acral melanoma origin and prognosis - Nature

Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

nature.com

biorxiv.org

Genomic profiling implicates candidate genes and mutagenic pathways driving lung cancer recurrence

Lung cancer remains the leading cause of cancer-related deaths worldwide, with tumor recurrence a major contributor to its high mortality. The genetic and molecular mechanisms of recurrence remain poo...

medrxiv.org

Functional modules predict cancer-relevant genetic interactions in mammalian cells

Genetic interactions can reveal gene function and identify cancer-relevant synthetic lethals, but systematic mapping in human cells is constrained by inefficient reagents, vast combinatorial search sp...

biorxiv.org

Protein that unties tangled DNA linked to hotspots of cancer mutations - Ontario Institute for Cancer Research

Research from the Ontario Institute for Cancer Research associated a chemotherapy-related cellular process with genetic mutations and used it to identify novel cancer driver alterations. New research ...

oicr.on.ca

Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes - Nature Communications

Topoisomerases resolve topological DNA stress via double-strand breaks and are established targets of cancer chemotherapies. Here, the authors link genomic binding of TOP2B with localized mutational p...

nature.com

Evidence for improved DNA repair in long-lived bowhead whale - Nature

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.  &nbs...

nature.com

SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200

Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.

nature.com

Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis - Nature Biomedical Engineering

Fluid shear stress plays a role in medulloblastoma metastasis through a PIEZO2-actomyosin-GLUT1 signalling cascade.

nature.com

Cancer genomic alterations and microenvironmental features encode synergistic interactions with disease outcomes

Abstract. Oncogenesis, tumor progression and therapy response are shaped by somatic alterations in the cancer genome and features of the tumor immune microenvironment (TME). How interactions between t...

aacrjournals.org

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky

Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

doi.org

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology

RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.

go.nature.com

GitHub - reimandlab/ActivePathways: Integrative pathway enrichment analysis of multivariate omics data

Integrative pathway enrichment analysis of multivariate omics data - reimandlab/ActivePathways

github.com

The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies - Nature

Nature - The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies

nature.com

Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process

Radiation, the most effective treatment for medulloblastoma, induces an innate immune response and opens the blood-brain barrier, allowing for the intravasation of tumor cells into the blood circulati...

cell.com

Transparent peer review to be extended to all of Nature’s research papers

From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.

nature.com

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience

In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...

nature.com