SPARHA represents a two-component defense system based on a suicidal cellular response, in which activation of the HNH effector by the pAgo sensor leads to filament formation, promoting efficient degradation of invading nucleic acids.

Preprint below has been a long time coming, here just in time for #microbio25 ! (if the train wifi lets me) With @andrewmatthews.bsky.social #MicroSky 🧵

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · last yr.

Stealth plasmids: rapid evolution of deleted plasmids can displace antibiotic resistance plasmids under selection for horizontal transmission. https://www.biorxiv.org/content/10.1101/2025.03.30.646151v1

Phage vs Phage from @annaolina.bsky.social at #Microbio25. Fantastic talk!

@samriddhigupta.bsky.social gave her poster presentation today at #Microbio25 about discovering new counter-defence systems in prophage genomes