We have just published a new protocol on integrative in silico and in vitro screening of small molecules targeting RNA! It combines virtual screening & NMR to identify and characterize RNA binders. currentprotocols.onlinelibrary.wiley.com/doi/10.1002/... #virtualscreening #NMR #RNA #targeting

Integrative <i>in silico</i> and <i>in vitro</i> screening of small molecules targeting RNA

Targeting structured RNA elements with small molecules has emerged as a promising yet technically challenging strategy for antiviral drug discovery. Here, we present a comprehensive and experimentall....

currentprotocols.onlinelibrary.wiley.com

Excited to contribute to the new Voices article on the future of fragment screening! Great to be part of this community effort. www.cell.com/structure/fu... #FragmentScreening #DrugDiscovery #StructuralBiology #NMR

Fragment screening in focus

In this Voices article, participants from the recent wwPDB Workshop on Fragment Screening at the EMBL-EBI and their colleagues discuss recent advances, current challenges, and future opportunities in ...

cell.com

Based on our newest publication, there is a new article on the webpage of the @goetheuni.bsky.social 😍 www.uni-frankfurt.de/en/newsroom/... #bacteria #science

How Dangerous Bacteria Survive | Goethe University Frankfurt

A collaborative team of scientists, including researchersGoethe University Frankfurt, has conducted research revealing how Streptococcus pneumoniae...

uni-frankfurt.de

Excited to see a new publication in Communications Biology! 🎉 Read it here: doi.org/10.1038/s420... #SialicAcid #StreptococcusPneumoniae #ABCTransporter #CarbohydrateTransport #StructuralBiology #Microbiology

Streptococcus pneumoniae substrate binding protein SatA specifically recognises the α-anomer of N-acetylneuraminic acid - Communications Biology

The respiratory pathogen Streptococcus pneumoniae uses the substrate binding protein SatA of the ABC transporter SatBC–MsmK to specifically bind the α-anomer of N-acetylneuraminic acid, the immediate ...

doi.org

Great to be at the @eptri.bsky.social Scientific Meeting 2026 in Warsaw this week! Meet us for talks from Director Prof. Harald Schwalbe (@schwalbe-lab.bsky.social) on interactions with EPTRI, plus great contributions from Jan Pribyl of @ceitec.eu and Oksana Degtjarik of @astbury-bsl.bsky.social!

Check out our new publication out in @commschem.nature.com 😍 "AI-assisted fragment-based drug discovery of SARS-CoV-2 macrodomain binders validated by NMR and X-ray crystallography" Full text: www.nature.com/articles/s42... #FBDD #NMR #Xray #AI #SARS-CoV-2

AI-assisted fragment-based drug discovery of SARS-CoV-2 macrodomain binders validated by NMR and X-ray crystallography - Communications Chemistry

Artificial intelligence and machine learning have recently accelerated fragment-based drug discovery (FBDD) processes through structure-based optimization and generative compound design. Here, the aut...

nature.com

Dr Irene Bessi and Maria Greve of the Prof. Claudia Höbartner group at @uni-wuerzburg.de gave a seminar outlining Instruct-funded access to @goetheuni.bsky.social! Thank you to GUF and Christian Richter for assisting with the access! @schwalbe-lab.bsky.social instruct-eric.org/centre/bmrz-...

Instruct director Prof. Harald Schwalbe visited the CTB12 conference in Siena, giving the opportunity to exchange with colleagues to discuss their research at the interface of Chemistry, Biology and Structures. #structure #biomolecules #CTB12

Thanks for having us as collaborators on this! @olallalab.bsky.social Congrats to everyone involved in developing a platform for photoswitchable RNA binders, enabling light-controlled RNA modulation and RNA-targeted therapeutics. Full text: chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion

An adaptable approach, many light-switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre-mRNA, restoring the leve...

chemistry-europe.onlinelibrary.wiley.com

@goetheuni.bsky.social is building BMRB Europe, an internationally connected NMR research database that will let data flow directly from spectrometers to the global research community, funded by the DFG. www.uni-frankfurt.de/en/newsroom/...

Frankfurt to Host International Bio Research Database

Internationally networked research database will collect structural data on biomolecules obtained worldwide through nuclear magnetic resonance (NMR) studies

uni-frankfurt.de

New publication alert from our lab 💥☺️ "Integrated NMR/MD investigation reveals differences after reweighting in conformational ensembles of GAAG and GCAA tetraloops" Full text: rnajournal.cshlp.org/content/earl... #NMR #MD #RNA

First talk by our director Prof Schwalbe @schwalbe-lab.bsky.social This conference is the opportunity to showcase integrated structural biology, we are now in our 7th edition. Tomorrow we will announce which Instruct country is hosting next! Read more here instruct-eric.org/ibsbc2026

Claudia Alen Amaro@claudialen.bsky.social · 3mo ago

The @instruct-eric.bsky.social Biennial Structural Biology Conference #IBSBC2026 is underway today in Brussels Thanks to our hosts @jansteyaert.bsky.social and his team at the highly successful #Nanobodies4Instruct facility Learn all about is and apply to access instruct-eric.org

Excited to share that our project (smART) has received funding approval from the German Research Foundation (DFG) as part of the latest funding round. We’re grateful for the support and looking forward to the next phase of exciting RNA research! 🥳 www.dfg.de/de/aktuelles... #Research #Funding #DFG

DFG fördert 13 neue Sonderforschungsbereiche

dfg.de

Die #DFG fördert zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 13 neue #Sonderforschungsbereiche (SFB). Die Themen reichen von der Erforschung extraterrestrischen Lebens bis zu Papieranwendungen der Zukunft. Einzelheiten 👉 www.dfg.de/de/aktuelles/…

Our recent publication exploring how complexity and “emergence” in chemistry may help explain the transition from non-living to living matter is now featured in a press release by Goethe University Frankfurt! Press release: www.uni-frankfurt.de/press-releas... Publication: doi.org/10.1002/anie...

Check out the new article: "Moving NMR infrastructures to remote access capabilities": www.sciencedirect.com/science/arti... #NMR #remote #datamanagement

Moving NMR infrastructures to remote access capabilities

Traditionally, Nuclear Magnetic Resonance (NMR) infrastructures have relied on in-person access, requiring researchers to travel to centralized facili…

sciencedirect.com

Interesting back-to-back papers from the Varani Group in @narjournal.bsky.social showing that an approved kinase inhibitor can specifically bind the HIV-1 TAR RNA element and influence its downstream function. A promising direction! academic.oup.com/nar/article/... academic.oup.com/nar/article/...

The kinase inhibitor palbociclib binds to HIV TAR RNA with very low nanomolar affinity and exquisite specificity

Abstract. We report that the kinase inhibitor Palbociclib is a very low nanomolar ligand for the HIV-1 TAR, a paradigmatic ‘difficult-to-drug’ RNA. Binding

academic.oup.com

Excited to see this work out in @narjournal.bsky.social! Our collaborators @weigandlab.bsky.social dissect how SARS-CoV-2 5'-UTR RNA structures and nsp1 protein variants co-evolve to control viral translation. We were glad to contribute to parts of this project! academic.oup.com/nar/article/...

Structure and sequence characteristics of 5′-stem-loop 1 modulate the escape from nsp1-mediated repression in SARS-CoV-2 variants

Abstract. Several SARS-CoV-2 variants have evolved with clinical relevance due to their structural and functional impact on viral proteins and genomic RNA

academic.oup.com

A new publication on G4s is online 💥 "Dissecting the Chemical and Thermal Stabilities of Tetrads in G-Quadruplexes to Derive a Structure-Activity Relation for a Thrombin-Binding DNA G-Quadruplex Aptamer" chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... #G4 #quadruplex #NMR

Dissecting the Chemical and Thermal Stabilities of Tetrads in G‐Quadruplexes to Derive a Structure‐Activity Relation for a Thrombin‐Binding DNA G‐Quadruplex Aptamer

Extended variants of the G-quadruplex thrombin binding aptamer exhibit differential anticoagulation activities. We show that 3’ terminal extensions increase nuclease resistance, while variations in t....

chemistry-europe.onlinelibrary.wiley.com

Great to see Bruker present our collaboration on facilitating RNA studies by NMR at this year's @enc-conference.org ! More to come soon...😊 #ENC #NMR #RNA #Bruker

Instruct director Prof. H. Schwalbe participate in the meeting of ITACA.SB, a national programme that supports structural biology in Italy to intensify the links of the Italian community with Instruct-ERIC Find out more here - instruct-eric.org/submit-propo... @schwalbe-lab.bsky.social

Our new review in @angewandtechemie.bsky.social is out! It explores the role of chemistry in emergence and complexity at the boundaries with biology, physics, and philosophy. A perspective on chemistry contributing to these interdisciplinary questions. onlinelibrary.wiley.com/doi/10.1002/...

The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence

This study explores the origins of life by linking prebiotic chemistry, the emergence of information-carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The ....

onlinelibrary.wiley.com

Have a look at our latest publication: Cupriavidus necator as an alternative source for 15N/13C isotopic enrichment of proteins expressed in insect cells for NMR - enabling structural studies of disease-relevant targets. Full text link: link.springer.com/article/10.1...

Cupriavidus necator, an alternative source for isotopic enrichment of proteins expressed in insect cells for NMR investigations - Journal of Biomolecular NMR

Isotopic enrichment of pharmacologically relevant protein targets is crucial for structural studies by nuclear magnetic resonance (NMR) and plays a key role in advancing structure-guided drug discover...

link.springer.com

Im Youtube-Kanal des Schreibzentrums findet ihr ein Interview von Harald Schwalbe zum Thema "Schreiben in den MINT-Fächern": www.youtube.com/watch?v=QKFR...

Prof. Dr. Harald Schwalbe - Schreibgespräch in der Organischen Chemie und Chemischen Biologie

YouTube video by Schreibzentrum Frankfurt am Main

youtube.com

G4 scientists be ready for the next international meeting on G4 structures - G4thering, which I organize with Robert Hänsel-Hertsch and Harald Schwalbe. At this meeting, G4 related science will be presented and discussed by top scientist. Join us in Frsnkfurt in summer 2027.

The first talk this morning comes from Harald Schwalbe of @goetheuni.bsky.social, Director of Instruct-ERIC, outlining the future directions of structural biology on the global scale. Find the full paper here - instruct-eric.org/news/the-fut... @schwalbe-lab.bsky.social @itqbnova.bsky.social

New paper out in microLife: evaluating proteomics workflows to reduce missing values, with a focus on reliable quantification of small proteins. Practical insights for improving coverage and data quality. academic.oup.com/microlife/ar... #Proteomics #MassSpectrometry #SmallProteins #Microbiology

Less missing values—evaluation of proteomics workflows for the quantification of (small) proteins

This study systematically evaluates methods for improving the identification and quantification of small proteins using bottom-up mass spectrometry, thereb

academic.oup.com

Fragment-Screen coordinator Harald Schwalbe is presenting on NMR screening and the outcomes of the project at the @eu-openscreen.bsky.social Impulse Winter Training School! Find out more about the meeting and Fragment-Screen here - fragmentscreen.org/winter-train... @schwalbe-lab.bsky.social

Great to see that the Instruct-ERIC review of the future of integrated structural biology is continuing to be highlighted! Find out more about the paper and read here - instruct-eric.org/news/the-fut... @schwalbe-lab.bsky.social

DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand Interactions | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand Interactions

Understanding the molecular recognition underlying RNA–ligand complex formation is of key importance to explain the RNA regulatory function of riboswitches and to support the development of low-molecu...

pubs.acs.org