The work spans: • Telomere Biology Disorder (#TBD) mice • Physiologically aged mice • Human hematopoietic stem/progenitor cells from healthy elderly donors www.nature.com/articles/s43...

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging - Nature Aging

Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in telomerase-deficient and physiolog...

nature.com

www.nature.com/articles/s43... Using telomeric #antisense #oligonucleotides (tASOs)vwe restored hematopoietic #stem cell fitness, improved #vaccination responses, reduced #senescence and #inflammation, and improved the function of aged human hematopoietic stem cells. Without elongating #telomeres.

What drives the pathological consequences of #telomere dysfunction? So far elomere shortening has been considered the central issue. In our new nataging.nature.com study, we show that telomeric DNA damage signalling itself is a causal driver of hematopoietic decline. www.nature.com/articles/s43...

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging - Nature Aging

Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in telomerase-deficient and physiolog...

nature.com

Online now!✨Oppezzo et al therapeutically block telomeric DNA damage signalling to restore hematopoietic function in telomerase-deficient and aged mice, while reducing senescence and inflammation @fdadf.bsky.social @ifomresearch.bsky.social www.nature.com/articles/s43...

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging - Nature Aging

Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in telomerase-deficient and physiolog...

nature.com

Happy to share our deep characterization of #LLPS events modulating the DNA damage response (#DDR) through #53BP1 condensation promoted by #dincRNA www.biorxiv.org/content/10.6...

Aging increases both #telomeric DNA damage and #Alzheimer’s disease risk. Fabrizio d'Adda di Fagagna and coworkers now find that these processes are linked, with Aβ42 oligomers triggering ROS-mediated telomeric damage that in turn increases neurotoxicity www.embopress.org/doi/full/10....

embopress.org/doi/full/10.10… Today on World Alzheimer's Day we published in @EMBO Journal that #Alzheimer's diseases (#AD) is associated with DNA damage at #telomeres and that inhibition of telomeric DNA damage signaling with telomeric #ASO improves neurons cell viability

www.semm.it/education/op... Join us!

Here is the link rdcu.be/eb9Kq for everybody to read our most recent Review on #aging and #cancer published in Nature Aging coauthored with Lucrezia Trastus - happy to read your comments. www.nature.com/articles/s43587-025-00827-z

The complex interplay between aging and cancer

Nature Aging - This Review explores the intersection between cancer and aging, illustrating shared causal mechanisms including genome instability, telomere dysfunction, cellular senescence and...

rdcu.be

I had the incredible opportunity to speak at #TEDxRoma. It was an intense and unforgettable experience. If you attended or watched the talk, feel free to share your thoughts with me! #Aging #longevity #telomere youtu.be/yTGj-5BVLXs?...

We know why we age | Fabrizio D'Adda | TEDxRoma

YouTube video by TEDx Talks

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