Online now!✨Cole et al identify fructose as a component of the therapy-induced SASP in senescent ovarian cancer cells and show that it reprograms cancer cells in paracrine, promoting detachment and metastasis @airdlab.bsky.social @wistar.org

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming - Nature Aging

Cole and colleagues identify fructose as a component of the secretome in therapy-induced senescent ovarian cancer cells that drives metastasis. Fructose metabolically reprograms neighboring cancer cel...

nature.com

✨SenNet Collection✨Browse all the papers from the SenNet project across the Nature Portfolio mapping senotypes, developing tools, and discovering biological & translational insights

The SenNet Collection

Cellular senescence was originally identified in tissue culture as an essentially irreversible proliferative arrest in primary cells in response to exhaustive ...

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✨SenNet collection✨In a perspective, Schafer, Basisty, Hertzel et al define and operationalize the term ‘senotype’, providing a framework to classify heterogeneous senescent cells

Senotypes define the diverse landscape of senescent cells - Nature Aging

This Perspective proposes a senotype framework for classifying senescent cells by their origins, molecular features and effects, which will foster comparison of diverse senescent states, including tho...

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✨The SenNet program aims to map and characterize senescent cells across age, tissue, and species. Discover research and opinion emerging from the SenNet project in a new cross-journal collection in the Nature portfolio ✨ www.nature.com/immersive/s4...

Online now!✨Calubag et al report that reducing dietary valine extends healthspan in male and female mice, and lifespan in male mice @lamminglab.bsky.social www.nature.com/articles/s43...

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice - Nature Aging

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

nature.com

Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells. www.nature.com/articles/s43...

Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature Aging

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

nature.com

🗞️Our July issue is live!✨Read about IL-11 as a target in ovarian aging, circulating metabolites connecting exposures to brain health, the effects of exercise on the aged human muscle multi-ome & much more nature.com/nataging/vol...

Online now! Janssens et al. analyze age, physical function, and acute exercise in the context of multi-omics of human skeletal muscle, linking fitness to distinct aging profiles. (rdcu.be/fsJ0V) doi.org/10.1038/s435...

Online now! A new study shows that IL-11, which is elevated in aging ovaries of mice, rats and humans, activates fibroblasts to secrete extracellular matrix, increasing ovarian stiffness. IL-11 is implicated as a potential therapeutic target for ovarian aging. doi.org/10.1038/s435...

Modulating IL-11-dependent matrix stiffness to delay ovarian aging - Nature Aging

The ovarian stroma becomes increasingly stiff with age, impairing ovarian function. The mechanisms that underlie this process are only partly understood. Here, the authors show that IL-11, which is el...

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Online now!✨Oppezzo et al therapeutically block telomeric DNA damage signalling to restore hematopoietic function in telomerase-deficient and aged mice, while reducing senescence and inflammation @fdadf.bsky.social @ifomresearch.bsky.social www.nature.com/articles/s43...

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging - Nature Aging

Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in telomerase-deficient and physiolog...

nature.com

Online now! Spatial atlas of aging mouse ovary shows that reproductive decline reflects progressive loss of spatiotemporal coordination #OvarianAging #WomensHealth @hattaca.bsky.social @davidsebfischer.bsky.social @akochersberger.bsky.social @jennifergarrison.bsky.social doi.org/10.1038/s435...

Aging disrupts spatiotemporal coordination in the cycling murine ovary - Nature Aging

Ovarian cycles of follicle development, ovulation and tissue regeneration require cooperative functions of constituent cells. Here the authors provide a spatial atlas of the aging mouse ovary, reveali...

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Online now! A Meeting Report from the Progeria Research Foundation’s 12th International Scientific Workshop reviews recent scientific advances and identifies strategic pillars to accelerate the development of Hutchinson–Gilford progeria syndrome therapies. rdcu.be/fpe5N doi.org/10.1038/s435...

🗞️Our June issue is live!✨Read about the healthspan and lifespan effects of time-restricted feeding in mice, insights from mathematical models of aging, how R-loops drive the SASP & much more nature.com/nataging/vol...

Online now!✨Raz et al fit survival data across species to a stochastic model of damage accumulation and removal; damage production rate best predicts lifespan, and species fall into two distinct aging regimes @navehr.bsky.social @urialonlab.bsky.social www.nature.com/articles/s43...

🗞️Our May issue is live!✨Read about immune mechanisms of calorie restriction identified from clinical trial data, tools to detect senescence burden via urine samples, asynchronous aging across female reproductive organs & much more www.nature.com/nataging/vol...

Online now! ✨Soldatkina, Ventura-San Pedro et al apply deep learning to histological and transcriptomic data from female reproductive organs across ages, reporting distinct and asynchronous aging trajectories detectable in independent plasma proteomics www.nature.com/articles/s43...

Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs - Nature Aging

The authors apply deep learning to histological and transcriptomic data from female reproductive organs from over 300 donors aged 20–70 years, reporting distinct and asynchronous aging trajectories, d...

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🗞️Our April issue is live! ✨The cover art depicts work on macrophage senescence as postage stamps 🎨The issue includes studies on improving vaccine efficacy in aging, endogenous regulation of cGAS, repurposing drugs for vascular dementia & much more nature.com/nataging/vol...

Online now! ✨Sopena-Rios, Ripoll-Cladellas use single cell transcriptomic data from nearly 1,000 female and male participants across the adult lifespan to profile sex-specific immune aging dynamics www.nature.com/articles/s43...

Online now! To dissect lncRNA functions in aging, here the authors perform a CRISPRi-based single-nucleus multi-omics screen perturbing 32 aging- and senescence-associated lncRNAs, and measuring matched changes in gene expression and chromatin accessibility. (rdcu.be/fblsB) doi.org/10.1038/s435...

Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence

Nature Aging - To dissect lncRNA functions in aging, here the authors perform a CRISPRi-based single-nucleus multiomics screen systematically perturbing 32 aging- and senescence-associated lncRNAs...

rdcu.be

Online now! Here the authors show that the killifish exhibit age-related transformation in the immune system which rapidly develops inflammation, genome instability, and functional decline. doi.org/10.1038/s435...

Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish - Nature Aging

Turquoise killifish are naturally short-lived vertebrates that serve as a model system for aging. The authors show that killifish exhibit age-related transformation in the immune system, which rapidly...

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🗞️Our March issue is live, with killifish artwork by Dario Valenzano on the cover!🎨Read work on senescence in mammary gland remodelling, structural protein changes as readouts of Alzheimer’s disease, the 201 Parkinson’s disease trial & more ✨https://nature.com/nataging/volumes/6/issues/3

Online now! Costa, Chen et al. performed RNA-seq on 13 tissues, six ages in male and female African turquoise killifish. The Killifish Aging Atlas provides a comprehensive resource for aging studies. @emkcosta.bsky.social @jingxunchen.bsky.social @brunetlab.bsky.social doi.org/10.1038/s435...

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature Aging

Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

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Online now! A new study shows transplanting gut microbiota from estropausal female mice to young adult female mice improves ovarian hormone profiles, follicle metrics, and fertility-related outcomes. @bbparis1984.bsky.social doi.org/10.1038/s435...

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice - Nature Aging

To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

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🗞️Our February issue is live! Read work on precision responses to therapy-induced senescence, senolytic resistance mechanisms, AD biomarkers in Latin America, the exposure of older adults to health misinformation, links from DNA damage in macrophages to autoimmunity & more ✨

Online now! ✨Chiche, Djoual, Charifou et al identify a dual role for senescence in postpartum tissue remodelling: senescent cells drive mammary gland involution, yet predispose to postpartum tumor initiation @hanli-pasteur.bsky.social @pasteur.fr

Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis - Nature Aging

Chiche, Djoual, Charifou and colleagues identify a dual role for cell senescence in postpartum tissue remodeling: senescent cells drive mammary gland involution, yet create a permissive niche for tumo...

nature.com

Online now! Study shows LINE-1 is increasingly expressed in mouse hearts with age, its de-repression is accompanied by cGAS-STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice. (rdcu.be/e0JU0) doi.org/10.1038/s435...

Targeting age-related LINE-1 activation alleviates cardiac aging - Nature Aging

LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genet...

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Online now! Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau181 and P-tau217. doi.org/10.1038/s435...

Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease - Nature Aging

Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau...

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Online now! Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show GRHL2 transactivates CDK19 to inhibit p53-p21 signaling, and demonstrate that GRHL2 gene therapy alleviates age-related urinary dysfunction in mice. (rdcu.be/e0fbZ) doi.org/10.1038/s435...

Reprogramming the GRHL2−CDK19 axis by gene therapy alleviates prostate aging - Nature Aging

The prostate is an important part of the male reproductive system whose aging process is incompletely understood. Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show that...

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Online now! Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. doi.org/10.1038/s435...

Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases - Nature Aging

In this technical report Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. scMORE revealed regulators...

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🗞️In our January issue, we celebrate the 5th anniversary of Nature Aging 🎉Read one Q&A from aging researchers, another Q&A to peek behind the scenes at the journal, our reflections on the past 5 years, and lots of great science too, here: nature.com/nataging/vol...