New paper out from our lab 🚀 Really fun collaboration with an awesome team leading by @azmicro.bsky.social Grateful to be part of it! #Microbiology #Klebsiella #InfectiousDisease #Science journals.plos.org/plospathogen...

Aerobactin is a key driver of hypervirulent Klebsiella pneumoniae translocation and virulence

Author summary The emergence of hypervirulent Klebsiella pneumoniae (hvKP) poses a significant public health threat due to its capacity to cause severe, often fatal, systemic infections. Of further co...

journals.plos.org

‼️ Excited to announce 1st session of #KlebClub2026! We kick things off with a session on pathogenesis, with *Jay Vornhagen* as keynote speaker, alongside 2 short talks selected from submitted abstracts - Sylvie MIQUEL & @microbiosaroj.bsky.social 🗓 Thursday 9 🕘 9:00 -10:30 AM (EDT) (1/2)

journals.asm.org/doi/10.1128/... Proud to see our work published in mBio! We uncover how C3 and C4 provide layered immune protection against Klebsiella pneumoniae. Grateful for my incredible mentors Dr. Ammar Zafar @azmicro.bsky.social, Dr. Karen Haas and supportive colleagues.

Divergent roles for complement components C3 and C4 in controlling Klebsiella pneumoniae gut colonization and systemic dissemination | mBio

Klebsiella pneumoniae, a major public health threat, resists antibiotics and can spread from the gut to the bloodstream, causing severe infections. Our study reveals how the immune system uses complement proteins C3 and C4 to block this spread. C3 limits bacterial growth in the gut through two potential mechanisms: (i) coating K. pneumoniae with fragments that signal bacteria-eating phagocytic cells to destroy it and (ii) recruiting more phagocytes into the gut. C3 also helps clear bacteria that escape into the blood. However, when antibiotic-resistant strains overgrow, C3 alone is insufficient. In these cases, C4 becomes critical, likely by enhancing C3’s ability to tag bacteria for elimination. This two-layered defense highlights new immune pathways that could be targeted to prevent bloodstream infections, especially in vulnerable patients or those colonized with drug-resistant bacteria. These insights open doors to innovative strategies against life-threatening Klebsiella infections.

journals.asm.org

Hard to believe it’s already that time of year! Our kick-off meeting for the Klebsiella Seminar Series just wrapped up. Stay tuned for more! @lauraamike.bsky.social @olayarendueles.bsky.social @caityholmes.bsky.social @tomstantonmicro.bsky.social @juanvalenciabacca.bsky.social WenWen Low & Jay V.

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/... Our new article in Current Protocols is out: Microbiologists, immunologists, host-pathogen folks: this one’s for you 🧬🦠 #Klebsiella #HostPathogen #Microbiology Huge thanks to my mentor @azmicro.bsky.social for the guidance and support!

Murine Models of Klebsiella pneumoniae Gastrointestinal Infection

Klebsiella pneumoniae (Kpn) is a Gram-negative opportunistic pathogen and a leading cause of hospital-acquired infections. The gastrointestinal (GI) tract serves as a critical site for Kpn colonizati....

currentprotocols.onlinelibrary.wiley.com

Klebsiella pneumoniae uses a type VI secretion system to overcome microbiota-mediated colonization resistance @azmicro.bsky.social @emorydeptofmed.bsky.social #microbiome #bacteria #pathogens #microbiology www.nature.com/articles/s41...

Don't miss the 4rth and last session of @klebclub.bsky.social focusing on #Klebsiella as part of complex microbial communities ! Our keynote speaker will be Kevin Foster, followed by some #phage talks from Mark Mimee and Sara Forsstrom! #microsky #phagesky Registration is free but necessary!

Session with four excellent lightning talks starts in 15 min! Link is in the email to all registered attendees. See you soon!

Olaya Rendueles@olayarendueles.bsky.social · last yr.

After a great first session on pathogenesis, the second Klebsiella Seminar Series @klebclub.bsky.social will discuss a variety of different topics. Join us for the lightning talks selected from submitted abstracts 🗓️ Thursday @9AM EDT (3pm Central European Summer Time) #microsky

We are back and excited for a great line up of speakers! Klebsiella Seminar Series 2025 starts next week 🙌 Join us on Thursday, April 3rd for Session 1 with talks focused on Pathogenesis. Registration is free at sites.google.com/view/klebclu.... Contact the organizers with any questions! #KlebClub