Laura
@kilarski.bsky.social
Resident doctor in psychiatry and postdoc with an interest in complex disease genetics, pharmacogenetics, long COVID and way too many other things at University Hospital Bonn, Germany. Also wife to a Plastic Paddy and mum to a 8yo boy who melts my heart.
☀️ We are happy to have Jente Meijer from the Bonn–Melbourne Joint PhD Program visiting us in Bonn this week! ☀️ Her talk “Towards precision psychiatry using multi-view clustering approaches” was a wonderful opportunity to learn how machine learning can be applied in psychiatry. 🎓🧠💻
Stop the CDU demanding information from NGOs that impinge on their freedom of speech, including the freedom to attend anti-right demos despite govermental funding - please sign the petition: weact.campact.de/petitions/sc...
weact.campact.de
Interesting new preprint: Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression: www.medrxiv.org/content/10.1...
Happy to share our newest work on #covid19 #hostgenetics ! An analysis of >1000 whole genomes with @kuludwig.bsky.social and Axel Schmidt at University of Bonn and Uniklinik Bonn, the DeCOI consortium and many colleagues from around Germany & beyond. #plospathogens journals.plos.org/plospathogen...
Systematic assessment of COVID-19 host genetics using whole genome sequencing data
Author summary After infection with SARS-CoV-2, symptoms vary widely. On average, individuals who are older, males and those with certain comorbidities tend to be more severely affected by COVID-19. A...
journals.plos.org
✨Psygenomics Lab escapes the psych ward! ✨ We had a lot of fun at our early Christmas outing at the psychiatry-themed escape room! 🧠🕵️♀️🎄
Happy new year! (It‘s been a while since I enjoyed the vast horizons on bluesky…)
New paper by Andy Dahl and I on phenotype integration improving GWAS power while preserving specificity is now out in Nature Genetics 🧬🎉 thank you all collaborators and reviewers! www.nature.com/articles/s41...
Phenotype integration improves power and preserves specificity in biobank-based genetic studies of m...
Phenotype imputation increases the effective sample size of major depressive disorder cases in UK Biobank, enhancing study power and polygenic risk score (PRS) accuracy. A new pleiotropy metric enable...
nature.com
My current view of psychological/psychiatric science: we have to be an order of magnitude more ambitions about the quality and quantity of the data we collect; in order to answer questions that are an order of magnitude more modest than the questions we think we can answer.
Does anyone happen to have access to this article? www.sciencedirect.com/science/arti...
Patient with Progressive Supranuclear Palsy Initially Diagnosed as Anxiety and Depression
La parálisis supranuclear progresiva (PSP) incluye un amplio espectro de síndromes relacionados con trastornos del movimiento y el comportamiento. Los…
sciencedirect.com
Non-coding rare variant associations with blood traits on 166,740 UK Biobank genomes https://www.biorxiv.org/content/10.1101/2023.12.01.569422v1
Non-coding rare variant associations with blood traits on 166,740 UK Biobank genomes https://www.biorxiv.org/content/10.1101/2023.12.01.569422v1
Large biobanks with whole-genome sequencing now enable the association of non-coding rare variants w
biorxiv.org
No, I didn’t get everything… www.nature.com/articles/s41...
Learning few-shot imitation as cultural transmission - Nature Communications
The modelling of human-like behaviours is one of the challenges in the field of Artificial Intelligence. Inspired by experimental studies of cultural evolution, the authors propose a reinforcemen...
nature.com
The BeeGees are not your thing? Well, the German Society for Anaesthesiology and the Professional Association of German Anaesthesiologists have created a Spotify playlist of songs suitable for keeping pace with the 100bpm needed for CPR: www.daebl.de/SR59. (Source: Deutsches Ärzteblatt)
100BPM - der Rhythmus der Herzdruckmassage
100BPM - der Rhythmus der Herzdruckmassage · Playlist · 86 songs · 324 likes
daebl.de
Genomic Medicine in 2023 open.substack.com/pub/albertvi...
Genomic Medicine in 2023
In the broad sense, the term "genomic medicine" encompasses various approaches and techniques that involve the analysis of biologically relevant molecules within an individual's genome. While genome s...
open.substack.com
Heritability of complex traits in sub-populations experiencing bottlenecks and growth https://www.biorxiv.org/content/10.1101/2023.11.23.568467v1
Heritability of complex traits in sub-populations experiencing bottlenecks and growth https://www.biorxiv.org/content/10.1101/2023.11.23.568467v1
Populations that have experienced a bottleneck are regularly used in Genome Wide Association Studies
biorxiv.org
🧪 Study of over a million genomes reveals links between specific genomic regions and cannabis addiction. These regions also relate to schizophrenia & lung cancer. Further, a two-way relationship between heavy cannabis use and schizophrenia is identified, highlighting potential mutual influence. 🩺🧬🖥️
Massive genetic study finds genes linked to cannabis addiction
Data from more than one million genomes offer fresh insights into excessive cannabis use and its relationship to other diseases. Data from more than one million genomes offer fresh insights into exces...
nature.com
Wichtige Beobachtungsstudie bei PCS: Antidepressiva aus der Gruppe der SSRI, die Serotonin erhöhen, führten bei 90% zu Besserung Hier die klinische Studie: www.nature.com/articles/s41...
Treatment of 95 post-Covid patients with SSRIs - Scientific Reports
Scientific Reports - Treatment of 95 post-Covid patients with SSRIs
nature.com
Another one for the „to read“-list: Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes jamanetwork.com/journals/jam...
The diffuse inflammation of the brain in symptomatic people with Long Covid by PET scans, with matched controls, and correlation with their blood inflammatory biomarkers www.biorxiv.org/content/10.1...
www.pnas.org/doi/full/10.... The immune cell census in the human body! These ~2 trillion cells collectively weigh ~1.2 kg, 40% are lymphocytes, 10% macrophages
Special collection of 21 papers showcasing a multi-omics analysis of the human brain at the cell-type level: www.science.org/collections/...
Brain cell census | Collections | AAAS
science.org
Interesting study on distinguishing bipolar disorder, currently depressed, from major depressive disorder, which is obviously rather relevant in everyday clinical work.. jamanetwork.com/journals/jam...
Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression
This diagnostic study evaluates a reproducible metabolomic biomarker signature in patient dried blood spots that differentiates bipolar disorder from major depr
jamanetwork.com
It took us 11 years but: Dopaminergic systems create reward seeking despite adverse consequences www.nature.com/articles/s41...
Dopaminergic systems create reward seeking despite adverse consequences - Nature
In Drosophila, a subpopulation of reward-encoding dopaminergic neurons antagonizes punishment-encoding neurons and can override punishment or hunger cues in favour of reward-seeking behaviour.
nature.com
Royal College of Psychiatrists report with recommendations for genetic testing in psychiatry is now out: www.rcpsych.ac.uk/news-and-fea... 🩺🧬🖥️
Groundbreaking new report recommends genetic testing for certain mental illnesses
A groundbreaking new report has recommended genetic testing for certain mental illnesses.
rcpsych.ac.uk
Genetics meets Transcriptomics: Expression and splicing outlier analysis in whole transcriptomes of individuals with schizophrenia: www.sciencedirect.com/science/arti...
Lifestyle and depression—this is a nice study that helps confirm the common wisdom in my field that helping people improve nutrition, physical activity, sleep, social connections while reducing alcohol consumption, smoking, and sedentary behavior reduces the risk of depression. #psychscisky #ClinPsy
The brain structure, immunometabolic and genetic mechanisms underlying the association between lifes...
Zhao, Yang et al. used UK Biobank data to examine the role of lifestyle factors in depression. They conducted multiple analyses and estimated underlying mechanisms related to brain structure, immunome...
nature.com