Could #CRISPR safely curb #InvasiveSpecies? 🐀 Professor John Marshall & @innovativegenomics.bsky.social researchers modeled Y-linked genome editors—a breakthrough technique to safely suppress invasive rodents—without the spread of gene drives or the hazards of rodenticide. ow.ly/pniz50ZvZks

A new approach to controlling invasive rodent populations with CRISPR

A new paper models a new approach to controlling rodent populations: Y-linked genome editors, or YLEs.

ow.ly

We are PUBLISHED!!! Our mechanistic work on how CRISPR-Cas ancestors unwind DNA and how this can be used to engineer hypercompact plant editors can now be found on Mol Cell- if you are interested in what defines a good genome editor, this read is for you 😎 🔗 www.sciencedirect.com/science/arti...

Out recently in Nature, a perspective piece on medical genome standards from IGI's Jennifer Doudna, Fyodor Urnov, Alex Marson, Brad Ringeisen, and collaborators. 🧬 Read here: https://ow.ly/HSXz50Zn0z7

Managing invasive species... with genome editing? 🐀 In a recent paper, IGI researchers design a new approach to controlling invasive rodent populations: Y-linked genome editors. Read more: https://ow.ly/gB9L50Zs8oh

Our ProteinGuide paper is finally out! Thanks to all the co-authors @junhaobearxiong.bsky.social, @ishangaur.bsky.social, @hnisonoff.bsky.social, @loltrogge.bsky.social, @jlistgarten.bsky.social, @savagecatsonly.bsky.social! @innovativegenomics.bsky.social www.nature.com/articles/s41...

Property guidance for protein sequence generative models with ProteinGuide - Nature Biotechnology

On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.

nature.com

🌱🌍 Published in Nature Reviews Bioengineering, "Genome engineering of plant photosynthesis for carbon sequestration" from IGI researchers from co-first authors Evan Groover and Flora Zhiqi Wang, and the Savage Lab, Niyogi & Lemaux labs! Read here: https://www.nature.com/articles/s44222-026-00453-3

A new multi-institutional initiative funded by ARPA-H through its THRIVE program is developing affordable gene-editing therapies for inborn errors of immunity in children. The award of up to $27.7M supports a platform approach to rapidly treat inborn errors of immunity: https://ow.ly/1MfE50ZsZEh

Our new paper on Y-linked CRISPR editors for invasive rodent control is featured by @innovativegenomics.bsky.social. innovativegenomics.org/news/a-new-a... #CRISPR #RodentControl

A New Approach to Controlling Invasive Rodent Populations with CRISPR

A New Approach to Controlling Invasive Rodent Populations with CRISPR - Innovative Genomics Institute (IGI)

innovativegenomics.org

Scientists have harnessed AI models to create synthetic CRISPR proteins that edit the genome more efficiently than those seen in nature go.nature.com/4f8AN3n

CRISPR gets a power boost from AI-designed ‘molecular scissors’

Researchers used artificial intelligence to design functional CRISPR enzymes not seen in nature.

go.nature.com

In a new paper, IGI researchers at UC Berkeley & UC San Diego develop a novel approach to controlling invasive rodent populations: Y-linked genome editors, combining scalability with a level of control that has previously been difficult to achieve: https://ow.ly/8mMx50Zs8of 🧪

I’m happy to share our pre-print exploring the activity and specificity trade-offs in adenine base editors. Thanks to my amazing co-authors Luke Oltrogge, @hnisonoff.bsky.social, and all the other contributors @jlistgarten.bsky.social @savagecatsonly.bsky.social @innovativegenomics.bsky.social 🧵1/7

Activity and specificity trade-offs in adenine base editors

Adenine base editors (ABEs) are CRISPR effectors that introduce A-T to G-C transitions in the genome using a nucleotide deaminase fused to a Cas protein. ABEs have been evolved to have very high editi...

biorxiv.org

At the IGI, we're using #robotics to accelerate research in critical areas like #Parkinson's disease. Learn more about one of our favorite robots and how IGI's Hanqin Li, Tomy Tran, and Dirk Hockemeyer are changing neurodegenerative disease research: https://ow.ly/RpMM50Zm85m

We're thrilled to officially welcome UC San Diego as an IGI partner campus! We're working to jointly develop cutting-edge genomic tools for addressing large-scale challenges in health and the environment. Read more about our plans: https://ow.ly/My0h50Zp8Lj

So excited to see our paper out in Science! Beyond grateful to my co-leads @petrskopintsev.bsky.social @evandeturk.bsky.social, all co-authors & collaborators, everyone in Doudna lab, and @innovativegenomics.bsky.social Being EsAIn in the DouDNA lab, it couldn't have been any other way ✨

Doudna Lab@doudna-lab.bsky.social · 3w ago

Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!

Out today in @science.org, Doudna lab researchers describe an #AI-assisted method for designing enhanced genome editors, testing close to 2000 in lab. Read more: innovativegenomics.org/news/ai-desi...

AI-Assisted Technique Allows Scientists to Design New, Functional Genome Editors Beyond What Can Be Found in Nature

AI-Assisted Technique Allows Scientists to Design New, Functional Genome Editors Beyond What Can Be Found in Nature - Innovative Genomics Institute (IGI)

innovativegenomics.org

Doudna Lab@doudna-lab.bsky.social · 3w ago

Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!

🎧 Listening tip! Jennifer Doudna, Nobel laureate and #CRISPR co‑developer, discusses how #GenomeEditing supports the development of more resilient and nutritious crops, while also promoting broad access & public dialogue 🌱 https://ow.ly/Yb3v50ZjZ24

What’s the Future of Gene Editing? | Quanta Magazine

In the first episode of the new season of ‘The Joy of Why,’ Nobel Laureate Jennifer Doudna discusses how she discovered CRISPR’s genome-editing power, the breakthroughs and hurdles during its explosive growth, and what lies ahead for this groundbreaking technology.

ow.ly

Out recently in Nature, new research from Jennifer Doudna, postdoc @jingkunzeng.bsky.social, and collaborators shows a #CRISPR-based method for selectively killing "undruggable" #cancers by recognizing cells with cancer-causing mutations and shredding their DNA. Learn more: https://ow.ly/NRss50Z8tQK

Just out from IGI's Jennifer Doudna, Fyodor Urnov, Alex Marson, Brad Ringeisen, and collaborators, a new Nature perspective piece on medical genome standards. 🧬 Read here: https://ow.ly/HSXz50Zn0z7

At the IGI, we're using #robotics to accelerate research in critical areas like #Parkinson's disease. Learn more about one of our favorite robots and how IGI's Hanqin Li, Tomy Tran, and Dirk Hockemeyer are changing neurodegenerative disease research: ow.ly/RpMM50Zm85m

🌱 New preprint from IGI's Moi Expósito-Alonso (MOILAB): "Catch me if you can: Arabidopsis thaliana lags in adaptation to contemporary climate change." Read here: https://ow.ly/hQF850Zlj0f

🏅 IGI's Brian Staskawicz (right) and Venkatesan Sundaresan (middle) receiving their Wolf Prizes in agriculture, along with 2025 co-winner Jonathan DG Jones!

Jennifer Doudna on #CRISPR #entrepreneurship, the sense of discovery in research labs, personalized medicine, #AI in biology research, and more! In conversation with Bloomberg's Emily Chang. Watch here: https://ow.ly/Ws4A50ZgsYq

Huge congratulations to Doudna Lab postdoc, Santiago!

Innovative Genomics Institute@innovativegenomics.bsky.social · 2mo ago

Congratulations to Santiago López in the @doudna-lab.bsky.social at the IGI for being selected for the 2026 class of the Pew Latin American Fellows Program in the Biomedical Sciences! Learn about Santiago's work and the other scholars here: www.pew.org/en/about/new...

The IGI Public Impact team’s Manar Zaghlula and Elizabeth Njuguna convened 50 regulators, innovators, and experts from 11 countries for a two-day workshop in Berkeley last week on an important topic: how do we create regulatory frameworks for genetically engineered microorganisms? #crispr 🧬🧪🦠

🧬📣New preprint from IGI's Brian Shy: "Ultra-large targeted DNA integrations in primary human cells." Read here: https://ow.ly/GvfE50Zc70I

"In […] ‘The Joy of Why,’ Nobel Laureate Jennifer Doudna discusses how she discovered CRISPR’s genome-editing power, the breakthroughs and hurdles during its explosive growth, and what lies ahead for this groundbreaking technology." #Conversations #CRISPR #GeneEditing #JenniferDoudna

What’s the Future of Gene Editing? | Quanta Magazine

In the first episode of the new season of ‘The Joy of Why,’ Nobel Laureate Jennifer Doudna discusses how she discovered CRISPR’s genome-editing power, the breakthroughs and hurdles during its explosiv...

quantamagazine.org

The IGI & Bakar Labs officially broke ground today on a new building, a world-class hub where scientific discovery, entrepreneurship & innovation can thrive together. https://innovativegenomics.org/news/igi-bakar-labs-building-groundbreaking/ #crispr UC Berkeley

New in Cell (Cell Press) from IGI's Alex Marson, using #CRISPR to study #HIV: "Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells." Read here: https://doi.org/10.1016/j.cell.2026.03.046

Congratulations to Santiago López in the @doudna-lab.bsky.social at the IGI for being selected for the 2026 class of the Pew Latin American Fellows Program in the Biomedical Sciences! Learn about Santiago's work and the other scholars here: www.pew.org/en/about/new...

Pew Supports 10 Leading Latin American Scientists

These 10 postdoctoral fellows from seven Latin American countries—Argentina, Brazil, Chile, Colombia, Mexico, Peru, and Uruguay—will each receive two years of funding to conduct research in laboratori...

pew.org

“The Joy of Why” is back. In our first episode of the new season, pioneering biochemist Jennifer Doudna talks about how her early, “rebellious,” decision to study RNA led her to a Nobel Prize. Tune in: podcasts.apple.com/us/podcast/w...

What’s the Future of Gene Editing?

Podcast Episode · The Joy of Why · June 11 · 51m

podcasts.apple.com