🔬 What if diagnosing and tracking AML could be done with one test?  At #ASH25, NMDP is sharing new MEASURE study results showing whole genome sequencing (WGS) can identify key AML mutations and offer clearer, more consistent data—moving us closer to modernized diagnosis and monitoring.  ⬇️

Logging back into Bluesky to ask for current best practices for presubmission enquiry @natureportfolio.nature.com. We have a massive piece of team science we are turning into important resource paper that will be cited++ @naturemedicine.bsky.social website asking for a form - do it or email editor?

Thank you for organizing this Simon. Agree, was a lovely speech from Dr. Lancaster.

Simon Richardson@simonrichardson.bsky.social · last yr.

Really exciting to co-organise the 20 year graduation reunion for Oxford medical school last night. Wonderful to reunite with old friends and hear retired DoS Tim Lancaster speak powerfully about how caring is at the heart of good medicine 💊❤️

What does a 40% NIH budget cut mean for funding chances (now ~15%)? You might think “60% of the money left = 9% success” ❌ NOPE!!! 1-3% because 80% of the budget is for existing grants New science? Starved Ongoing grants? Slashed 😢 #FundingScienceSavesLives

We have 2-3 group leader positions opening @fimm-uh.bsky.social !! We are looking for outstanding candidates in human genetics and precision medicine. This time we have a focus on population health data science. E.g. AI for EHR/health data        Generous starting package 💰 shorturl.at/FAk6n

FIMM-EMBL Group Leaders in Molecular Medicine

FIMM-EMBL Group Leaders in Molecular Medicine

jobs.helsinki.fi

Breaking News: The Trump administration halted Harvard’s ability to enroll international students, a major escalation in its battle with the school.

Trump Administration Halts Harvard’s Ability to Enroll International Students

nytimes.com

Discussed this at a dinner yesterday with mild surprise that it hasn’t already happened - once in a generation discount on the opportunity to turn capital into legacy.

Carolyn Bertozzi@carolynbertozzi.bskyverified.social · last yr.

If people of means are interested in establishing a 2025 “Institute for Advanced Study” for displaced/defunded biomedical scientists, I know many people who will help, including myself. @mcuban.bsky.social @arcadiascience.com @arcinstitute.org

Appreciate shoutout to old literature

Michael Drazer@michaeldrazer.bsky.social · last yr.

Was discussing a recent case with a colleague when the utility of the day 14 marrow in our patients undergoing intensive induction for AML was discussed. Prompted a return to the "old" literature on this topic, much of which was written by Eli Estey (and @drchrishourigan.bsky.social).

Check this chart. Purple line: NIH actual budget (as passed by Congress) after 2000. This is in real (inflation-adjusted) dollars. The Trump/Vought proposal for 2026 (yellow) is catastrophic, for US science and medical cures for Americans. That's a massive drop.

The hits just keep on coming...

Biotech shares today. What did I miss?

Current administration proposes 18 BILLION dollar cut (~40%) to NIH medical research for FY26 (closer to 45% if new budget 27B not 48.5B+inflation). National Science Foundation cuts of ~56% proposed. whitehouse.gov/wp-content/u.... @altnih4science.bsky.social @davelevitan.bsky.social

NEW: Per multiple sources, the National Cancer Institute’s Board of Scientific Advisors has been entirely disbanded.

TFW you get an email from @ash.hematology.org and realize that you are about to age out of eligibility for the William Dameshek Prize...

old man yells at cloud is written on a newspaper

ALT: old man yells at cloud is written on a newspaper

media.tenor.com

Taking from NIH research to create a new MAHA agency? wapo.st/42gLz0Z Summary: Proposal: $47B NIH budget split into $27B for NIH (now only 8 institutes, from 27) and $20B for a new "Administration for a Healthy America" (incl. primary care, childhood chronic disease).

Internal budget document reveals extent of Trump’s proposed health cuts

HHS would be asked to absorb a $40 billion cut, about one-third of its discretionary budget.

wapo.st

Incredible

It’s stunning to me that the New York Times did not put the story on the bloodbath at the NIH, CDC, and FDA on its front page this morning.

The crazy thing about firing all of these federal employees is that they tend to be underpaid, super hardworking, in it for the right reasons, idealistic people who could’ve worked in industry or pharma and made way more money but they truly believed in the mission and the good they were doing.

Incredible story, very well told. At the intersection of purpose-driven scientific research, dedicated federal employees working tirelessly without credit for the public good, rare diseases under radar of the power of the market, and “healthcare” in the US. Sharing as a gift article: wapo.st/3DyAWgz

Opinion | The free-living bureaucrat

Michael Lewis on Heather Stone of the Food and Drug Administration.

wapo.st

Tell me you don't understand the research and innovation process w/o saying it. McKinsey report from DOGE staff now at NIH on "leading through change: preparing for government transition". I went to HBS specifically to think seriously about how federal research agencies could improve - this ain't it

Johns Hopkins to cut more than 2,000 jobs after $800M in federal cuts

Judge orders Trump officials to offer jobs back to fired probationary workers

Vibes

As I get older myself I’ve become less tolerant of the “more of a comment than a question” elders.

a man with a mustache is standing in front of a crowd and says " be curious not judgmental "

ALT: a man with a mustache is standing in front of a crowd and says " be curious not judgmental "

media.tenor.com

HHS is not renewing yearly contracts of researchers at NIH. The 1st cohort will be terminated 3/8. If continued, this will end careers of 1000s of scientists, and will cripple intramural research. email secretary Kennedy and your congressional reps today! docs.google.com/document/d/1...

Dear [Secretary Kennedy, or insert name of member of congress or senate]

Please send this letter to Secretary Kennedy and to members of congress and the Senate. Secretary Kennedy’s email address is and phone is here. Find your congressional rep here. Many do not have an em...

docs.google.com

None of this is normal

More hits to #NIH: "The Trump administration has imposed a new restriction on employment that could push out thousands of NIH’s senior scientists: The agency cannot retain scientists in 1-year to 4-year positions that have long been routinely renewed." 🧪 @jocelynkaiser.bsky.social at @science.org

NIH ban on renewing senior scientists adds to assaults on its in-house research

Policy follows firings of tenure-track scientists and suspension of training programs

science.org

These were, hands down, the most rigorous external reviews I've ever done. What the leadership wanted to know was, are these investigators and programs "outstanding?" And they, and our review committee, took that word both literally and seriously.