Elia Mascolo

@eliamascolo.bsky.social

Postdoc researcher at ISTA in Gašper Tkačik's group, studying biological evolution through the lens of information theory. Math enthusiast and amateur jazz piano player. https://eliamascolo.github.io/

So hyped to see the paper out!! 🤩 A great within-lab collab: 2 undergrads, 2 postdocs, 1 PI, cute rainbow darters, and much fun! 🌟 Please read (now-faculty ❤️) Kara's recap to learn more about what we did, she has a real knack for storytelling! ⏬️

Dr. Kara M. Million@darterdancer.bsky.social · 5mo ago

First rule of darter fight club is... nah, we're totally going to talk about darter fight club right here in our new paper!! I'm pleased to share the latest from myself, @izziehb.bsky.social , @tamramendelson.bsky.social, and two brilliant undergraduate co-authors! #FishSci #FishSky 🐟❤️ 1/

I'm really excited to join ISTA's scientific community! I feel really welcome 🤗 Looking forward to doing awesome science together!

Institute of Science and Technology Austria (ISTA)@istaresearch.bsky.social · 5mo ago

Article in TIME, featuring ISTA postdoc @eliamascolo.bsky.social​. After 4 years in the US, he moved to Austria with the APART-USA fellowship, a program that supports outstanding researchers in relocating their work to Austria. 🔗 https://time.com/7379376/scientist-migration-us-to-europe/

ISTA postdoc Elia Mascolo

With @eliamascolo.bsky.social we'll be presenting this project at the #EvoKE2025 conference in Athens🇬🇷 this November! Check out what the initiative is doing to promote the education and outreach of (biological) evolution in Europe! ➡️ @evokeproject.bsky.social

Izzie Héjja-B.@izziehb.bsky.social · last yr.

With @eliamascolo.bsky.social we developed an interactive class on biological evolution (focusing on mutations 👾) for science #teacher through a card game 🎲 We crash-tested it with #HighSchool students from Milan and made it available online for broader use: replicards.netlify.app #SciCom #EvoBio

Happy to announce that our study on the latent cis-regulatory potential of mobile DNA is officially published! TLDR: mobile DNA in bacteria (Insertion Sequences) have a proclivity for evolving new promoters. At least 25% of them probably already encode functional promoters as well.

The latent cis-regulatory potential of mobile DNA in Escherichia coli - Nature Communications

The mechanism and extent to which transposons can alter the gene expression of their hosts is not well understood. This study finds that in the IS3 family of transposable elements in E.coli, de-novo p...

nature.com

The best part was seeing students who were never exposed to #evolution concepts using evolutionary thinking to interpret the results of the card game. Only after they figured out what was going on, we introduced the scientific jargon (like "selection" and "drift") used to refer to those phenomena.

Izzie Héjja-B.@izziehb.bsky.social · last yr.

With @eliamascolo.bsky.social we developed an interactive class on biological evolution (focusing on mutations 👾) for science #teacher through a card game 🎲 We crash-tested it with #HighSchool students from Milan and made it available online for broader use: replicards.netlify.app #SciCom #EvoBio

Why are 🦠 genes organized into operons? Gene copy number fluctuates depending on distance from ori due to DNA replication. Operons keep gene clusters balanced in terms of copy number, reducing unbalance in expression level. Evo explanation for metabolic operons 👇 journals.asm.org/doi/10.1128/...

A new selective force driving metabolic gene clustering | mSystems

The formation of clusters of functionally related genes in microbial genomes has puzzled microbiologists since their discovery. Here, we suggest that replication, and the copy number variations due to...

journals.asm.org

Reading through a thread on latest conda TOS issue Conda TOS changed last year, and they're blocking IPs from larger nonprofit organizations (such as universities) with more than 200 connections/downloads. Connections will remain blocked until targeted organizations pay up. 💻🧬🧪

Can AlphaFold3 predict bacterial transcription factor binding sites on DNA? I tried to devise a fair test. The results are quite impressive. My test: I chose LexA (favorite TF at the @ErillLab) from E. coli K-12, and I generated "randomized" binding sites from the PWM. First 1/