Tessera

Dimple Notani

@dimplenotani.bsky.social

Associate Professor, NCBS, Bangalore. Interested in signaling driven gene regulation, enhancers, genome organisation, RNA

9 Posts201 Follower 247 Folgt

Elena Torlai Triglia @elett.bsky.social · last wk.

1/ New paper alert! 🎉🧬 Our study on #9p21 gene regulation is out in #CellGenomics: "Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes" (Torlai Triglia, Miller, et al. www.cell.com/cell-genomic... 🧵

Ana Pombo @apombo1.bsky.social · last mo.

bioRxiv alert! CoPhasing resolves haplotype-specific 3D chromatin structures from GAM data, revealing extensive structural heterogeneity between human homologous chromosomes and its interplay with histone modifications and gene expression! Thanks to all coauthors! www.biorxiv.org/content/10.6...

biorxiv.org

Wendy Bickmore @wbickmor.bsky.social · 3mo ago

Although cohesin-sensitive, long-range enhancer activation is equivalent in nature to proximal activation. Cooperativity can arise from different levels of activation inputs operating on a non-linear response function. @eliasfriman.bsky.social @uoe-igc.bsky.social www.biorxiv.org/content/10.6...

Alexis Verger 🧬🧫🧪@alexis-verger.cpesr.fr · 3mo ago

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

Ranjith Padinhateeri @ranjithpa.bsky.social · 3mo ago

Our new preprint: Chromatin at ~10–100 kb scales behaves very differently from standard polymer expectations. DNA-PAINT data reveal broad fluctuations and sharp local bends. Our study suggests emergent active forces at these scales and quantifies the nature and strength of this activity

Ranjith Padinhateeri @ranjithpa.bsky.social · 6mo ago

Happy to share our Current Opinion review on the key challenges in accurately predicting 3D distances between chromatin segments and computing their dynamics. Thanks to @djost-physbiol.bsky.social @lucagiorgetti.bsky.social for the invitation to write this review! @shuvadipdutta.bsky.social

Anders Sejr Hansen @andersshansen.bsky.social · 6mo ago

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...

Dimple Notani @dimplenotani.bsky.social · 6mo ago

Exited to share Current Opinion review on how chromatin hubs involving multiple enhancers and promoters are formed, and their potential roles in gene regulation: www.sciencedirect.com/science/arti...

Dimple Notani @dimplenotani.bsky.social · 7mo ago

Glad to share our latest work that came out recently. We dive into the mechanisms of how Transcription Factors (TFs) like the nuclear receptor, ERα navigate the genome to find their targets.

Dimple Notani @dimplenotani.bsky.social · 10mo ago

The deadline for common entrance exam (JGEEBILS) for I-PhD and PhD is on 26th October. Please apply! @ncbsbangalore.bsky.social @tifr.res.in

Ana Pombo @apombo1.bsky.social · last yr.

Join us for the 2025 GRC Genome Architecture www.grc.org/genome-archi... @spp2202.bsky.social @jobdekker.bsky.social @metorrespadilla.bsky.social @jopkind.bsky.social @dimplenotani.bsky.social @stanleyqilab.bsky.social @andybelmont.bsky.social @fondufemittendorf.bsky.social @boyanbonev.bsky.social

National Centre for Biological Sciences, Bengaluru @ncbsbangalore.bsky.social · last yr.

#PhDone! 🎓 Congratulations Dr Rajat! 🎉 Rajat Mann from Dr Dimple Notani's lab successfully defended his thesis! 🧵⬇️Scroll to know more about his work on transcription regulation 🧬 @dimplenotani.bsky.social (1/5)

Congratulations Dr Rajat Mann from dr dimple notani lab at NCBS, Bangalore for succesfull thesis defence . Thesis titled " RNA provides specificity to transcription factor binding and condensate dynamics"

NCBS, Bengaluru , National centre for biological sciences, bangalore

National Centre for Biological Sciences, Bengaluru @ncbsbangalore.bsky.social · last yr.

#NewComicAlert! Our latest comic with Tinkle Comics Studio featuring the inspiring story of Dr Dimple Notani is out now! Dimple is an Associate Professor at NCBS studying gene regulation. Check it out and let us know your thoughts in the comments below! #sciencecomics @dimplenotani.bsky.social

Title: Meet Superwoman Dimple Notani!
Publisher: NCBS, Tinkle Issue #821 (February 2025)

This comic introduces Dimple Notani, a scientist studying gene regulation, through engaging illustrations and dialogue.

Panel 1: An elephant, a monkey, and a woman stand in a green outdoor setting. The elephant says, "I’m big and I have a trunk." The monkey, swinging from a tree, adds, "I have long arms that help me swing from trees." The woman, dressed in an orange shirt and blue jeans, says, "I walk on two legs and don’t have a trunk or long arms. We are so different! Yet, our DNA is 98% similar!" This highlights genetic similarities despite physical differences.

Panel 2: A scientist in a white lab coat and glasses stands with the group. She explains, "We all have a genetic code—our DNA. It contains instructions that determine height, eye color, behavior, and more." The characters listen attentively.

Panel 3: The scientist introduces DNA’s four building blocks: A, T, G, and C. A diagram shows how these nucleotides pair. She explains, "These letters are in all DNA. Their arrangement creates differences between species. When their order changes, they form different ‘words’ and ‘sentences,’ leading to changes in us." A footnote clarifies that nucleotides are DNA’s building blocks.

Panel 4: In a lab, a digital display of a DNA helix is shown. The scientist, joined by her students in lab coats, says, "We study DNA’s ‘sentences’ to understand genetic differences." A student adds, "Our field of study is gene regulation."

This educational comic explains DNA and gene regulation through engaging visuals and simple analogies, emphasizing how genetic codes shape living beings.
Continued to page 2

Title: Meet Superwoman Dimple Notani! (Page 2)
Publisher: NCBS, Tinkle Issue #821 (February 2025)

This page continues introducing Dr. Dimple Notani and her passion for decoding DNA.

Panel 1: A surreal scene features an elephant with tiger stripes, a monkey with a trunk, and a tiger walking upright like a human and a woman with one half of her hair curly and the other half straight. Dr. Notani explains, "There is a reason an animal looks and behaves in certain ways. We don’t often question how it all works. Decoding this is my passion."

Panel 2: Dr. Notani, in a lab coat, speaks to two colleagues. She says, "Decoding DNA is like finding the secret language of life. It helps us understand why some people get diseases and some don’t, helping prevent or treat them." She holds a folder while explaining.

Panel 3: A young girl observes tadpoles and wonders, "How do they become frogs?" An inset of Dr. Notani states, "I didn’t always know I would have such an awesome job." Another inset adds, "Even though I wasn’t always good at studies, I was fascinated by animals and insects."

Panel 4: A younger Dr. Notani, excited, thinks, "I have to tell my professors about this discovery!" She explains, "My curiosity turned into a passion for understanding differences. My school teacher encouraged me to pursue science. Despite hardships, I became my family’s first graduate and scientist."

Panel 5: Dr. Notani shares, "My postdoctoral mentor, Michael Geoff Rosenfeld, inspired me. I now encourage young people to pursue science. No matter the challenges, you’ll find a way past them!" A note clarifies "Studies done after PhD."

The comic concludes: "Dimple Notani is associated with the National Centre for Biological Sciences, Bengaluru."

Ranjith Padinhateeri @ranjithpa.bsky.social · 2y ago

Had a wonderful time discussing chromatin when some friends visited IIT Bombay, Mumbai! @vram142.bsky.social @dimplenotani.bsky.social @kaushikr.bsky.social