Notice of award from NIGMS for our R35 application on "Mechanisms of Translational Control" for the next 5 years. Nice way to celebrate a full year at Brown University and Giuliani RNA Center at Brown.
DjuranovicLab at Brown University RNA Center
@djuranoviclab.bsky.social
RNA, Ribosome, miRNA, mRNA, translation, translational control, sometimes splicing
It is a great privilege to be named Mencoff Family RNA Research Professor of Molecular Biology, Cell Biology and Biochemistry at Brown University. I am grateful to Mencoff Family, Brown University, Department of Molecular Biology, Cell Biology, and Biochemistry and Guiliani RNA Center.
Our RAPPL international patent application has just been published.
Visit from a friend and great colleague from Newcastle University. Sergey Melnikov will after snowy February in Providence talk tomorrow about hibernating ribosomes. Another talk at Brown RNA Center. #ribosomes #RNA
Great collaboration with Dougherty and Pavlovic Djuranovic labs on using MPRAs to look into non-coding mutations. Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes www.sciencedirect.com/science/arti...
Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes
Coding mutations can cause neurodevelopmental disorders (NDDs), including autism. Yet, predicting which non-coding (e.g., 5′ untranslated region [UTR]…
sciencedirect.com
A short synopsis of a recent Symposium at Brown University and inaugural Giuliani RNA Center meeting. It was an honor to be part of it. www.brown.edu/news/2025-09...
Researchers, industry leaders convene at Brown to explore the potential of RNA
Brown’s Giuliani RNA Center and the Rhode Island Life Science Hub co-hosted a symposium focused on how scientists can work together to turn RNA discoveries into solutions.
brown.edu
We are looking for a new postdoctoral fellow interested in the further development of our RAPPL technology and studies of translational complexes. Preference will be given to candidates with either structural biology or ribosome profiling backgrounds. www.nature.com/articles/s41...
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies - Nature Communications
Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a wide variety of cell and ti...
nature.com
Please join us for the Inaugural Brown RNA Center Symposium with a Keynote Speakers Melissa Moore and Craig Mello, guests Victor Dzau, Jack Reed and Subra Suresh, as well as more talks and panels including both scientific and industrial speakers and panelists. sites.brown.edu/rna-symposium/
RNA Without Borders: Academic Insights, Industry Impact
Join research and industry leaders in RNA science for a dynamic symposium uniting cutting-edge innovation with real-world solutions for the health of people and planet. September 26-27, 2025The Warren...
sites.brown.edu
Four days of science at @events.embl.org in Heidelberg for "Protein Synthesis and Translational Control" meeting.
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions rdcu.be/ezlhg
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies
Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...
rdcu.be
Our collaboration with Tony Mustoe's lab us out today. MPRA libraries and possible cryptic splicing in MPRA reporters, or reporters in general. The additional novelty here is that such events are controlled or influenced by AU-rich sequences. www.nature.com/articles/s41...
U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays - Nature Communications
Massively parallel reporter assays (MPRAs) are powerful technologies for measuring the impact of non-coding sequences on gene expression. Here, the authors demonstrate that MPRA reporters often underg...
nature.com
First RAPPL ribosome isolation at the new lab space at Brown University. Purification from a small culture of parasitic Eukaryote. Soon out... www.biorxiv.org/content/10.1...
@djuranoviclab.bsky.social is from today officially part of Brown University and Brown RNA center. We will have our new website soon. rna.brown.edu
The Brown RNA Center | Medical School | Brown University
Our mission is to advance RNA science through fundamental discovery, technology development, and translational impact that accelerates life-changing health solutions.
rna.brown.edu
Last month @uspto.bsky.social issued yet another patent to Slavica Pavlovic Djuranovic, Jessey Erath and @djuranoviclab.bsky.social for use of polybasic peptide or non-peptide moieties against malaria parasites. More soon...
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (6/6). Archaea #1 www.biorxiv.org/content/10.1...
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (5/6). Eukaryotic #3 www.biorxiv.org/content/10.1...
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (4/6). Eukaryotic #2 www.biorxiv.org/content/10.1...
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (3/6). Eukaryotic #1 www.biorxiv.org/content/10.1...
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (1/6). Bacterial #2 www.biorxiv.org/content/10.1...
Some of the ribosomes purified using RAPPL and Cryo-EM structures solved in last couple of months (1/6). Bacterial #1 www.biorxiv.org/content/10.1...
This was a fun collaboration with Maxim Arttyomov lab on how itaconate inhibits the active site of a peroxiredoxin enzyme. Thanks Maxim for including us in this. www.nature.com/articles/s42...
Itaconate modulates immune responses via inhibition of peroxiredoxin 5 - Nature Metabolism
Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the type I interferon prod...
nature.com
Ribosome data collected from a new and precious sample of 10,000,000 cells from a strange organism. All done using RAPPL, more soon... www.biorxiv.org/content/10.1...
3 years after terrible loss (two -80C freezers and all back-ups) of almost all of our collection of regular and mutant human, Drosophila, E. Coli and Plasmodium cells, we are still not finished with insurance.
One of the best single step purification preparations of protozoan ribosomes I've ever seen. Combination of RAPPL (biorxiv.org/content/10.1...) and a new technique. More at rna.ucsc.edu/rnacenter/ri...
🚨The triennial Ribosome Conference will be held June 22-June 27, 2025 in Pacific Grove, California. Registration is open - hope to see many #Ribosome #RNA aficionados there. #RNASky #AcademicSky 🧪 rna.ucsc.edu/rnacenter/ri...
Ribosomes2025 Program
The Ribosome Conference is held every three years and brings together researchers working on all aspects of the ribosome, from structure and function to its role in disease and use as a drug target.
rna.ucsc.edu
Ok after @cryoclem.bsky.social we also tried Archaeal ribosomes (and some proteasomes) with RAPPL (www.biorxiv.org/content/10.1...) as well as some specific translation cycle complexes with new method.
After RAPPL (www.biorxiv.org/content/10.1...) we found another way to get ribosomes and other macromolecular complexes easier to the cryoEM grids. This time besides ribosomes p97 complexes were purified (back to the PhD times). Stayed tuned...
