Intricate Molecular Mechanisms Help Bacteria Evade Immune Detection - News Center

Northwestern scientists have identified a novel mechanism utilized by the bacteria responsible for gonorrhea to evade immune detection and achieve widespread infection, according to a recent study pub...

news.feinberg.northwestern.edu

Registration | Midwest Microbial Pathogenesis Conference 2026

mmpc2026.umn.edu

BR-bodies link RNA homeostasis to stress tolerance and intracellular fitness in Brucella

Bacterial gene expression depends on the coordinated regulation of RNA synthesis, processing, and decay. The conserved RNA degradosome scaffold, Ribonuclease E (RNase E), assembles into phase-separate...

biorxiv.org

Bacteria sense virus-induced genome degradation via methylated mononucleotides

Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...

science.org

OpenEvo: An Open-Source Platform for Automated Evolution and Analysis

Here we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-s...

biorxiv.org

QutRNA2: robust tRNA modification discovery from Nanopore direct tRNA sequencing

Abstract. Transfer RNAs (tRNAs) are essential for protein synthesis and are extensively modified to ensure their structure and function. Direct RNA sequenc

academic.oup.com

Research Specialist - Madison, Wisconsin, United States

Current Employees: If you are currently employed at any of the Universities of Wisconsin, log in to Workday to apply through the internal application process.Job Category:Academic StaffEmployment Type...

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Shedding light on YfhS and YjlC: novel effectors of the NADH dehydrogenase activity of the electron transport chain in Bacillus subtilis - PubMed

Oxidative phosphorylation is the most efficient way of generating ATP in respiring cells. As high energy electrons are the major source of reactive oxygen species their production needs to be carefull...

pubmed.ncbi.nlm.nih.gov

YhaM Structure Revealed in PNAS | Christine Dunham posted on the topic | LinkedIn

We are excited to present our recent research published in PNAS in collaboration with the Yap lab from Northwestern. Congrats to Jacob Mattingly who led our structural biology efforts and Anna Lipońsk...

linkedin.com

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

Om Nom Gets Sticky Shocked by Pizza Dough

ALT: Om Nom Gets Sticky Shocked by Pizza Dough

static.klipy.com

Purine bias in bacterial genes is driven by runaway transcription

Nature Microbiology, Published online: 15 June 2026; doi:10.1038/s41564-026-02389-1Purine bias is critical for gene expression in bacteria, preventing premature transcription in species that exhibit runaway transcription.

go.nature.com

Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer

embl.org

Opinion | Get the Federal Science Money Flowing

The NIH has been holding back grants from funds Congress has already approved.

wsj.com

An expanded reference catalog of translated open reading frames for biomedical research

Abstract. Non-canonical (i.e. unannotated) open reading frames (ncORFs) have until recently been omitted from reference genome annotations, despite evidenc

academic.oup.com

Assistant Professor of Biochemistry - Protein Homeostasis - Amherst, Massachusetts, United States

Title: Assistant Professor of Biochemistry - Protein Homeostasis Executive Area: Academic Affairs College/School/MBU: College of Natural Sciences Department: Biochemistry/Molecular Biology Work Locati...

careers.umass.edu

Moonlighting in metabolism: bifunctional enzymes control nitrogen metabolism in Bacillus subtilis | Microbiology and Molecular Biology Reviews

SUMMARYGlutamate is an essential building block and the most important amino group donor in the cell. The reactions involved in synthesis and degradation link carbon to nitrogen metabolism. The synthesis and activity of the enzymes catalyzing these reactions must, therefore, be precisely regulated. In the Gram-positive model bacterium Bacillus subtilis, glutamate is exclusively synthesized by the combined action of the glutamine synthetase (GS) and the glutamate synthase (GOGAT). The GS catalyzes the ATP-dependent assimilation of ammonium, resulting in the formation of glutamine. Glutamine is converted together with 2-oxoglutarate by the GOGAT into glutamate, which can be used either for further assimilation of ammonium, or as a building block, or amino group donor. The glutamate dehydrogenases (GDHs) GudB and RocG are strictly devoted to glutamate degradation. In recent years, exciting new observations have been made in nitrogen metabolism in B. subtilis. The GS, GOGAT, and the GDHs are multifunctional enzymes, with the GS and GDHs acting as trigger enzymes in the control of gene expression, in addition to their enzymatic activity. The glutamate-synthesizing GOGAT acts as a counter enzyme, inactivating the major GDH GudB to prevent a futile cycle. In this review, we intend to summarize the current state of knowledge about nitrogen metabolism in B. subtilis and discuss open questions that need to be answered in the future.

journals.asm.org