mdpi.com

Temporal changes in hyaluronan concentrations in preterm human milk - Journal of Perinatology

Journal of Perinatology - Temporal changes in hyaluronan concentrations in preterm human milk

nature.com

Hyaluronan 35 prevents endotoxin-mediated dysregulated skeletal muscle proteostasis during ethanol exposure

Sarcopenia in alcohol-related liver disease (ALD) is of high clinical significance, but there are no effective treatments. Hyaluronan 35 kDa (HA35), a glycosaminoglycan polymer, modulates responses to...

uknowledge.uky.edu

Neuropil aggrecan, not perineuronal nets, closes the critical period for visual plasticity

Perineuronal nets (PNNs) are widely reported to close developmental critical periods and restrict experience-dependent plasticity. Here we tested this model by selectively eliminating gene expression ...

biorxiv.org

From matrix to nucleus: CD44 as a central regulator of inflammaging, autophagy, and tissue homeostasis - Biogerontology

Aging is characterized by a progressive decline in cellular and tissue function, shaped in part by disruptions in communication between the extracellular matrix (ECM) and intracellular signaling netwo...

link.springer.com

Hyaluronan and CD44 targeting reverses early matrix changes, proinflammatory signals and fibrosis in primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a rare, progressive liver disease characterized by biliary inflammation and bile duct strictures and no approved medical therapy. Despite its clinical severity,...

biorxiv.org

Hyaluronan (HA) Receptors: Discovery, Function & Pathology

Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid-β-(1-3)-N-acetylglucosamine polymerized by β(1-4) bonds, with no obvious active site for biological activity...

onlinelibrary.wiley.com

Testosterone therapy is trending. Who really needs it, and why?

Nature - Some clinicians are pushing to broaden testosterone use, but there is debate about its benefits and risks.

go.nature.com

Extracellular matrix stiffness directs region-specific lung epithelial differentiation revealed by hPSC-derived lung organoids - Nature Communications

Using human pluripotent stem cell-derived lung organoids, the authors show that extracellular matrix stiffness directs region-specific lung differentiation, revealing a key mechanical cue that guides ...

nature.com

sciencedirect.com

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sciencedirect.com

MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer

MEN1 governs CD44 alternative splicing and CD44 variant generation to activate ferroptosis and disrupt lung cancer development, highlighting the potential of targeting this axis to treat MEN1-deficien...

aacrjournals.org

A queen odour mediates reproductive suppression in a eusocial mammal - Nature

Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females t...

nature.com

Photopatterned spatiotemporal organisation and in situ differentiation of 3D human cortical networks

Modelling human cortical microcircuitry in vitro requires platforms that recapitulate both the compositional complexity and spatial architecture of developing neural tissue. Current organoid and assem...

biorxiv.org

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

nature.com

sciencedirect.com

sciencedirect.com

Recruiting Postdoc for Immediate Start

The MRI lab seeks a postdoctoral researcher for an NIH-funded position studying hyaluronan science, mechanobiology, and biomechanics, with research spanning animal models, ECM biology, and AFM-based t...

engineering.purdue.edu

Coupled Transcriptomic and ECM‑Mechanical Remodeling Reveal Mechanotransductive Pathways in Spinal Cord Injury

Spinal cord injury (SCI) leads to the formation of a chronic scar composed of glial and fibrotic components that severely restrict neural regeneration and functional recovery. While the scar compositi...

biorxiv.org

sciencedirect.com

Proteomic analysis reveals 4-methylumbelliferone-induced metabolic shift and downregulation of CD147/MMP2 axis in U937 Cells

Acute Myeloid Leukemia (AML) is a hematological malignancy with poor therapeutic outcomes, as up to 50% of patients relapse or become refractory to treatment. The identification of novel therapeutic s...

researchsquare.com

4-Methylumbelliferone for type 1 diabetes therapy: evidence for β-cell protection via EGFR/PI3K/Akt signaling - Journal of Endocrinological Investigation

Purpose Type 1 diabetes mellitus (T1DM) results from autoimmune-mediated destruction of pancreatic β-cells, leading to absolute insulin deficiency. Current treatments rely on insulin replacement and d...

link.springer.com

A loss of inter-α-inhibitor Heavy Chain 5 (ITIH5) leads to corneal thinning and increased corneal inflammation following injury and early onset geriatric decline

Inter-alpha trypsin inhibitor (IαI) proteins contain heavy chains (ITIHs, traditionally HCs), and ITIH5 is the most highly expressed ITIH isoform in t…

sciencedirect.com

mdpi.com

Mechanisms and Evolutionary Advantages of Unlimited Reproductive Lifespans in Naked Mole-Rat Queens

The naked mole-rat (Heterocephalus glaber) defies mammalian norms with lifelong fertility and postnatal oogenesis. Unlike most mammals, which experience reproductive senescence due to depletion of a f...

annualreviews.org

TMEM2 regulates hyaluronan turnover and cartilage homeostasis during early osteoarthritis progression

Osteoarthritis (OA) is characterized by progressive cartilage degeneration, yet the initiating molecular events remain incompletely understood. Transmembrane protein 2 (TMEM2), a cell-surface hyaluron...

biorxiv.org

Depolarization of the membrane potential by hyaluronan - PubMed

The membrane potential is mainly maintained by the K(+) concentration gradient across the cell membrane between the cytosol and the extracellular matrix. Here, we show that extracellular addition of h...

pubmed.ncbi.nlm.nih.gov

The aging extracellular matrix as a missing link in senescent cell accumulation and persistence - Nature Aging

Emerging evidence suggests that extracellular matrix (ECM) states can shape both senescence entry and persistence by tuning integrin signaling and mechanosensing. We propose a self-reinforcing circuit...

nature.com

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