@drakesmith-lab.bsky.social
#WIMMinFocus Not a T.rex but a pretentious gut tissue! Spatial transcriptomics mapped 5,100 genes at subcellular resolution. Captured by @vywien-lai.bsky.social, winner of the 2025 WIMM Image Competition ( #SciArt). Proof that science doesn’t just uncover life’s mysteries — it gives you dinosaurs 🦕
It was fun to make this with our fabulous collaborators!
MRC Weatherall Institute of Molecular Medicine@imm.ox.ac.uk · 12mo ago📽️ Check out our latest video, where we speak with the @drakesmith-lab.bsky.social and their collaborators in @oxuniearthsci.bsky.social & @biology.ox.ac.uk to find out how they're tackling iron deficiency - the world's most common nutritional deficiency 🧪 @rdm.ox.ac.uk | @ox.ac.uk Watch here 👇
2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...
Iron and the immune system - Nature Reviews Immunology
Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...
nature.com
Exciting and provocative paper for the iron field! www.nature.com/articles/s41...
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos - Nature
Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
nature.com
@rbeagrie.bsky.social thank you- but as you know (although modestly omitted) you made several absolutely crucial contributions and it could not have happened without you!
Rob Beagrie@rbeagrie.bsky.social · last yr.Delighted to have been able to help out with this project - congratulations Ali and the rest of the @drakesmith-lab.bsky.social - such a fascinating #genetics and #GeneRegulation story 🧪
Wonderful to see this out, a big effort led by Alexandra Preston and fun for the lab to do something new (and very very old); plus it’s only slightly iron-related! 😳😱😀 www.nature.com/articles/s41...
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis - Nature Communications
Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control during erythropoiesis and may ex...
nature.com
Supercool Linda and team!
Linda Sinclair@lindavsinclair.bsky.social · 2y agoI am overjoyed to present our latest paper on Autophagy in CD8 Tcells! www.nature.com/articles/s41... It was, as all ‘sciencing’ is, a huge team effort. I will try to do it some justice in the following thread 😊 1/n @cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
The December issue of Trends in Endocrinology and Metabolism is online! With a Feature Review on iron utilization from cellular biochemistry to clinical pathology (on the cover), articles on vitamin D, hepatic gluconeogenesis, autophagy and lysosomal dysfunctions, hypoxia during pregnancy and more!
Ever wondered why our cells need iron? Check out the new Feature Review from the Drakesmith Lab in the latest issue of Trends in Endocrinology & Metabolism to learn more!🧪 Read the review: bit.ly/3CYA3NC
Why cells need iron: a compendium of iron utilisation
Iron deficiency is globally prevalent, causing an array of developmental, haematological, immunological, neurological, and cardiometabolic impairments, and is associated with symptoms ranging from chr...
bit.ly