Marija Dramicanin
@dramarija.bsky.social
Head of Protein Production Facility at Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
🔬 We’re recruiting: Translational Research Scientist (Cell Therapy Manufacturing) Join the Jenkins Lab at WEHI and be at the forefront of research in immunotherapy for brain cancer. For full details and to apply visit: wehi.wd3.myworkdayjobs.com/WEHI/job/Par...
Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead ! www.cell.com/structure/fu...
Code to complex: AI-driven de novo binder design
In this review, Fox et al. discuss how artificial intelligence has transformed our ability to design new-to-nature proteins that bind target proteins with high affinity and specificity. The authors de...
cell.com
Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/ Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic ⚔️🦠❄️🔬
New to nature proteins are the future! Proud to have contributed to this groundbreaking work! 🏴☠️
Rhys Grinter@rhyswg.bsky.social · last yr.Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the @knottrna.bsky.social lab, with experimental work led by the talented @danielrfox.bsky.social www.nature.com/articles/s41...
Lab Heads positions are available at our institute in beautiful Melbourne! 👇🏻
WEHI (The Walter and Eliza Hall Institute of Medical Research)@wehi-research.bsky.social · last yr.🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery. For more information and to apply 👇
RFdiffusion ✌🏻 www.biorxiv.org/content/10.1...
Atom level enzyme active site scaffolding using RFdiffusion2
De novo enzyme design starts from ideal active site descriptions consisting of constellations of catalytic residue functional groups around reaction transition state(s), and seeks to generate protein ...
biorxiv.org
Many familiar names from labs in Australia in this exciting preprint! Congratulations!!! www.biorxiv.org/content/10.1...
De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development, yet the design of protein agonists and antagonists has been challenging as ...
biorxiv.org
Netflix’s #Adolescence is a masterpiece that everyone should watch.
We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in Melbourne, Australia 🔬🦘💥 Work in a cutting edge research environment in a vibrant world city! We value research excellence, creativity and diversity. Join us! careers.petermac.org/job/MELBOURN...
Group Leader
Group Leader
careers.petermac.org
Check out the updated version of the de novo Ab design preprint 👇🏻 www.biorxiv.org/content/10.1...
Atomically accurate de novo design of antibodies with RFdiffusion
Despite the central role that antibodies play in modern medicine, there is currently no method to design novel antibodies that bind a specific epitope entirely in silico. Instead, antibody discovery c...
biorxiv.org
In case you missed the BindCraft paper 👇🏻. www.biorxiv.org/content/10.1...
BindCraft: one-shot design of functional protein binders
Protein–protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present B...
biorxiv.org
Today marks 10 years since I moved to Australia! Can’t think of a better place to be. Back to where it all started @lorneproteins.bsky.social
De novo design of protein minibinder agonists of TLR3. Congrats to the authors! www.nature.com/articles/s41...
De novo design of protein minibinder agonists of TLR3 - Nature Communications
This study reports the computational design of miniprotein binders of the pattern recognition receptor TLR3. When oligomerized, the miniprotein binders induce TLR3 signaling in cells, suggesting they ...
nature.com
In Nature Chemical Biology today, we reveal how microbes clean our atmospheres by consuming carbon monoxide (CO) gas. A methodological tour de force from Ashleigh Kropp, Rhys Grinter, and David Gillett with broad implications for the atmosphere and bioenergetics. www.nature.com/articles/s41...
Quinone extraction drives atmospheric carbon monoxide oxidation in bacteria - Nature Chemical Biology
Here, Kropp et al. use cryo-electron microscopy and structural modeling to show that the enzyme [MoCu]-CO dehydrogenase interacts with its partner, the membrane-bound quinone-binding protein CoxG, to ...
nature.com
“De novo designed proteins neutralize lethal snake venom toxin” paper from the Baker lab just published in Nature. www.nature.com/articles/s41...
De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
nature.com
Interactive Program now live for the Lorne Protein Conference 2025! Merry Christmas and Happy New Year! www.lorneproteins.org
To get the things going on this platform, I decided to start sharing some interesting de novo protein design papers! Hope you find them useful! www.biorxiv.org/content/10.1...
Development of a De Novo Protein Binder that Inhibits the Alpha Kinase eEF2K
Elongation factor 2 kinase (eEF2K) is calmodulin activated and phosphorylates eEF2, a GTPase, that regulates global translation. When eEF2K phosphorylates eEF2, protein translation is halted. This pro...
biorxiv.org
Australia's got de novo binders! 🎉 Congrats to @danielrfox.bsky.social @rhyswg.bsky.social, @cyntiat.bsky.social, @gavinjknott and all authors on their incredible work featured in two preprints below. Thrilled to have contributed to the ChuA story, such an exciting advance in Protein Biochem!
Rhys Grinter@rhyswg.bsky.social · 2y agoExcited to share our first foray in ML-guided protein design. With the @gavinjknott lab we designed protein binders as that block heme piracy by pathogenic E. coli and potently inhibit CRISPR-Cas13. www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...
