L'artiste franco-iranienne Marjane Satrapi, autrice de "Persepolis", est décédée à 56 ans Ah bordel merde, ça fait chier ça... www.rts.ch/info/culture...

L'artiste franco-iranienne Marjane Satrapi, autrice de "Persepolis", est décédée à 56 ans | RTS

L'artiste franco-iranienne Marjane Satrapi, qui s'est fait mondialement connaître avec la bande dessinée et le film "Persepolis", est décédée à l'âge de 56 ans, a appris l'AFP jeudi auprès de son ento...

rts.ch

Finally out 🎉 New paper in Nature Chemical Biology! Using RF-diffusion, we designed protein inhibitors that bind the CRISPR Cas13a active site, something very hard to find in nature. Thanks to everyone involved for the hard work! 👏 www.nature.com/articles/s41...

De novo design of potent CRISPR–Cas13 inhibitors - Nature Chemical Biology

Taveneau et al. leverage artificial-intelligence-driven protein design to create inhibitors that control RNA-targeting enzymes in cells, revealing a strategy to rapidly design off-switches for RNA-edi...

nature.com

Big news! 🎉 The CRISPR Down Under 2026 speaker line-up is out. Join us in Melbourne (24–25 Mar) for two days of exciting CRISPR science, great talks & great people ! Early-bird & abstracts close 30 Jan ! 🔗 crispr.org.au

CRISPR Down Under 2026 is here! 📍 Melbourne | 📅 Mar 24–25 2026 Early-bird ends Jan 30! Register & Abstracts : crispr.org.au Join us for cutting-edge CRISPR research! #CRISPR #MelbourneEvents

CRISPR Down Under

Melbourne Connect, 700 Swanston St, Carlton VIC 3053 Tuesday 24th - Wednesday 25th March, 2026

crispr.org.au

Big milestone for the AI Protein Design Program last November: our first AI binder design workshop! Proud of the team and grateful to @kmichie.bsky.social for her amazing talk. This is just the beginning… excited for what’s next! #AI #ProteinDesign #AIPDP

Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead ! www.cell.com/structure/fu...

Code to complex: AI-driven de novo binder design

In this review, Fox et al. discuss how artificial intelligence has transformed our ability to design new-to-nature proteins that bind target proteins with high affinity and specificity. The authors de...

cell.com

Thrilled to be part of this great @ausbiocommons.bsky.social initiative : a webinar serie on AI-based binder design :) I’ll be sharing a case study on using deep learning to design programmable CRISPR inhibitors 12 August 12pm AEST, love to see you there ! www.biocommons.org.au/events/prote...

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c... #CryoEM #Membranes

ASBC and Biocommons are building opportunities for researchers to discuss and explore protein design tech. First up is @rhyswg.bsky.social. Excited for this!

WEBINAR SERIES: Leveraging deep learning to design custom protein-binding proteins — Australian BioCommons

Be inspired by case studies that show you how deep learning methods are speeding up the process of designing proteins with desirable biophysical properties. More information Register

biocommons.org.au

Proud to share some of the work from my PhD is now out in Nature Communications! Very grateful to all coauthors who helped make this happen, especially my supervisors @rhyswg.bsky.social and @knottrna.bsky.social for their support. 🩸 🦠 🔬

Rhys Grinter@rhyswg.bsky.social · last yr.

Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the ‪‪@knottrna.bsky.social‬ ‬lab, with experimental work led by the talented @danielrfox.bsky.social www.nature.com/articles/s41...

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬 📄 www.biorxiv.org/content/10.1... 🌐 search.foldseek.com/folddisco

An epic sky, singing cicadas, and a solar explosion. See this and more in this month's best science shots https://go.nature.com/3ZaM0rD

See the Milky Way dazzle during a lunar eclipse — May’s best science images

The month’s sharpest science shots, selected by Nature’s photo team.

go.nature.com

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Science Magazine@science.org · 2y ago

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion. Learn more in this week's issue: scim.ag/3FA3Ygq

"Nous devons attaquer honnêtement et agressivement les universités de ce pays." Ces mots sont ceux du vice-président américain J.D. Vance en 2025. Claire Mathieu, mathématicienne à l’ENS et membre de l’Académie des sciences, alerte : la science et la quête de vérité sont menacées aux États-Unis.

New isolates from eukaryote's closest archaeal relative: ‘Hodarchaeales’!! Syntrophic microaerotolerant peptide-degrading anaerobic archaea w/ simple cell structure & protrusions. Features conserved across the phylum provide new insight into our ancestor’s biology! www.biorxiv.org/content/10.1...

Eukaryotes' closest relatives are internally simple syntrophic archaea

Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...

biorxiv.org

Session 9 Cyntia Taveneau: De novo design of crispr-cas inhibitors. CRISPR system degrades DNA from phage; phage escape with antiCRISPR. Can we design them?? AIcrs designed to block active site of Cas13. #RFdiffusion Scoring top 96. Expr and purify. Biolayer interferometry. #LorneProteins2025

Petit reportage de France Inter sur notre utilisation de l'IA au labo: - Combiner prédictions informatiques et validations expérimentales - Un nouveau monde à explorer - Des utilisateur.rice.s divers doivent s'approprier l'IA pour inventer des usages divers. www.radiofrance.fr/franceinter/...

"On est entré dans un nouveau monde" : comment l'IA révolutionne la microbiologie

En permettant de prédire la structure d'une protéine à partir d'une séquence d'ADN, Alphafold, le système mis au point par Google DeepMind, a ouvert en grand le champ des possibles pour les chercheurs...

radiofrance.fr

Scaling data analyses in cellular cryoET using comprehensive segmentation [new] Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.

We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...

Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates - Nature Structural & Molecular Biology

Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility an...

nature.com

After a decade in the oven🧑‍🍳, we’re happy to finally share our preprint on the in situ architecture of the ciliary base. 📜 https://dir.lat/41qAY4 We used #CryoET to resolve transition zone structures and reveal the stepwise assembly of IFT...

More than 1'800 tomograms available for the community. Towards visual proteomics using our favorite organism Chlamy! Check out the preprint: www.biorxiv.org/content/10.1... Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com #TeamTomo

Towards community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii

In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate structures of biomolecules in their native context. However, challenges remain in the efficient production...

biorxiv.org

Do you want to work at the interface of molecular simulations, structural biology experiments and #AI? Come to Paris for a PhD at @pasteur.fr 1 PhD position is available in our lab funded by ERC_Research. Please repost!! #compchem #compbio Info 👇 research.pasteur.fr/b/15Hr

Interactive Program now live for the Lorne Protein Conference 2025! Merry Christmas and Happy New Year! www.lorneproteins.org

A postdoctoral position is available in our team to study the type VI secretion system. Biochemistry, X-ray cryst and some cryoEM with @fronzeslab.bsky.social team Reposts appreciated 😊

This is such a cool initiative! DL4Proteins is democratizing deep learning for protein design and prediction at a pivotal time in science—a fantastic step toward making advanced protein engineering accessible to all! github.com/Graylab/DL4P...

GitHub - Graylab/DL4Proteins-notebooks: Colab Notebooks covering deep learning tools for biomolecular structure prediction and design

Colab Notebooks covering deep learning tools for biomolecular structure prediction and design - Graylab/DL4Proteins-notebooks

github.com

www.science.org/doi/10.1126/...

Antiviral signaling of a type III CRISPR-associated deaminase

Prokaryotes have evolved diverse defense strategies against viral infection, such as foreign nucleic acid degradation by CRISPR-Cas systems and DNA/RNA synthesis inhibition via nucleotide pool depleti...

science.org

1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM. www.youtube.com/playlist?lis...

2024 S2C2 Single-Particle Cryo-EM Image Processing Workshop - YouTube

This playlist contains six recordings covering single particle cryo-EM data processing in CryoSPARC from the 2024 Single-Particle Cryo-EM Image Processing Wo...

youtube.com

To get the things going on this platform, I decided to start sharing some interesting de novo protein design papers! Hope you find them useful! www.biorxiv.org/content/10.1...

Development of a De Novo Protein Binder that Inhibits the Alpha Kinase eEF2K

Elongation factor 2 kinase (eEF2K) is calmodulin activated and phosphorylates eEF2, a GTPase, that regulates global translation. When eEF2K phosphorylates eEF2, protein translation is halted. This pro...

biorxiv.org