Uncovered: early molecular warning signs of inflammatory bowel disease reveal the condition can begin before symptoms appear and continue silently even when patients appear well. Published in @science.org 🔗 www.wehi.edu.au/news/researc...

Out now in @science.org A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease | Science www.science.org/doi/10.1126/...

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Although current therapies aim to cor...

science.org

From infection to protection: Could mosquitoes help eradicate malaria? Advances in drug discovery suggest someday they might. See press release👇 from @wehi-research.bsky.social www.science.org/doi/10.1126/...

Chemovaccination with a late-liver-stage antimalarial induces durable immunity against malaria

Plasmodium falciparum sporozoite vaccines, in which parasites are attenuated at the liver stage, provide high efficacy but require complex manufacture and intravenous administration of high sporozoite...

science.org

WEHI (The Walter and Eliza Hall Institute of Medical Research)@wehi-research.bsky.social · 3mo ago

A WEHI-led study has demonstrated a novel late liver-stage malaria immunisation strategy that can generate durable, multi-layered immunity using a parasite-arresting drug candidate. Mosquito bites then boosted the immune response over time. Published in @science.org

Chemical inhibition of Plasmodium plasmepsin proteins offers a new path for drug-based malaria vaccination www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @science.org @drboddey.bsky.social @wehi-research.bsky.social

Our paper on CALM vaccination is out: late liver-stage inhibition of plasmepsin IX/X induces long‑lived sterile protection. Thanks to wonderful coauthors & funders for making this possible. @wehi-research.bsky.social @mercksharpanddohme.bsky.social #Malaria #Vaccines www.science.org/doi/10.1126/...

Chemovaccination with a late-liver-stage antimalarial induces durable immunity against malaria

Plasmodium falciparum sporozoite vaccines, in which parasites are attenuated at the liver stage, provide high efficacy but require complex manufacture and intravenous administration of high sporozoite...

science.org

On Wednesday 12 August, there will be a total solar eclipse, the Perseid meteor shower and a six-planet alignment 🤩

Read how the incredible long-acting injectable drug lenacapavir that prevents HIV is facing challenges reaching the people that need it most 👇

Science Magazine@science.org · 3mo ago

One shot of lenacapavir, a new HIV prevention drug, can protect for 6 months—but aid cuts and uncertain demand mean little of the drug has reached the countries that most need it. Learn more: https://scim.ag/44TIW5G

Pathway 8

Solstice

Goodbye X, Hello bsky. These images taken on the same night from my backyard let you know it's me.