Congratulations to @drishitachandel.bsky.social, recipient of Physiology's High-Impact Research Award! The award recognizes graduate students and postdocs who publish first-author papers in Nature, Science, or Cell. A well-deserved honor following her recent first-author Science paper.

And there it is. As rumored, and as predicted by YHN from the gitgo, enhanced triage of NIH grants will continue. grants.nih.gov/grants/guide...

Out now in @science.org Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis | Science www.science.org/doi/10.1126/...

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis

Suppressor transfer RNAs (sup-tRNAs) can rescue disease-causing nonsense mutations by promoting readthrough of premature termination codons (PTCs). Their clinical translation is limited by suboptimal ...

science.org

Yikes: “I cannot do my best work in America,” said Zamore. “I can’t recruit the best people to help me do that, and I can’t promise them an environment where they’ll be safe.” www.wbur.org/news/2026/08...

Why a UMass researcher is among the dozens leaving the U.S. for Canada

A renowned scientist at UMass Chan Medical School is moving his lab to Canada. The Canadian government named RNA researcher Phillip Zamore among the first recipients of awards that will total more tha...

wbur.org

This is truly heartbreaking. Dolly Parton was an extraordinary person and an irreplaceable champion of the working class. We are a better country because of her.

Fantastic from Ishita Chandel, graduate from my old department BioBio at Texas A&M

University of Iowa Molecular Physiology and Biophysics@uiowaphysiology.bsky.social · 4w ago

Congratulations to Dr. Ishita Chandel, Dr. Kevin Campbell, and the Campbell Lab on their new paper in Science! Their discovery uncovers a new way dystroglycan controls its own function, providing important insights into diseases caused by defective dystroglycan activity. doi.org/10.1126/scie...

Congratulations to Dr. Ishita Chandel, Dr. Kevin Campbell, and the Campbell Lab on their new paper in Science! Their discovery uncovers a new way dystroglycan controls its own function, providing important insights into diseases caused by defective dystroglycan activity. doi.org/10.1126/scie...

Xylose phosphatase activity of dystroglycan self-regulates its receptor function

Dystroglycan (DG) is an extracellular matrix receptor crucial for tissue development and pathogen entry. DG harbors a long, complex glycan called matriglycan. Loss of matriglycan or reduction in its length disrupts DG function, causing ...

doi.org

Exclusive: NSF set to issue lowest number of new grants in four decades www.nature.com/articles/d41... 🧪 #AcademicSky @nature.com

I’m very excited to share my main postdoctoral work where we show that dystroglycan, a ubiquitous transmembrane receptor important for development, neuromuscular function and virus entry, regulates its own posttranslational modification by acting as a glycan phosphatase. #glycotime #neuromuscular

Stella Hurtley@smhsci.bsky.social · 4w ago

Out now in @science.org Xylose phosphatase activity of dystroglycan self-regulates its receptor function www.science.org/doi/10.1126/...

Out now in @science.org Xylose phosphatase activity of dystroglycan self-regulates its receptor function www.science.org/doi/10.1126/...

Xylose phosphatase activity of dystroglycan self-regulates its receptor function

Dystroglycan (DG) is an extracellular matrix receptor crucial for tissue development and pathogen entry. DG harbors a long, complex glycan called matriglycan. Loss of matriglycan or reduction in its l...

science.org

I’m very excited to share my main postdoctoral work now out @science.org #glycotime www.science.org/doi/10.1126/...

Xylose phosphatase activity of dystroglycan self-regulates its receptor function

Dystroglycan (DG) is an extracellular matrix receptor crucial for tissue development and pathogen entry. DG harbors a long, complex glycan called matriglycan. Loss of matriglycan or reduction in its l...

science.org

No they are not. Stop it. The answer to any hint of legitimacy is “fund science better”. Stop wasting an R01 with every Patriot missile salvo in the Middle East.

John Timmer@jtimmer.bsky.social · 2mo ago

I tried to acknowledge that the report identifies a few issues that the scientific community is already talking about, like the NIH's focus on funding incremental advances and the administrative burden on faculty. Those are real areas of debate.

I co-sign this great summary from @dereklowe.bsky.social . The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.

Derek Lowe@dereklowe.bsky.social · 2mo ago

Thoughts on the various Trump administration proposals to revamp US science funding - and what they all have in common:

Exclusive: Satchidananda Panda, a prominent biologist known for his work on circadian rhythms, light sensing, and intermittent fasting, will resign next month after 22 years at the Salk Institute for Biological Studies. scim.ag/4f9F5Yi

Prominent Salk Institute biologist to resign following sexual misconduct investigation

Staffers complain that Salk allowed circadian rhythms researcher Satchidananda Panda to depart quietly, while the allegations and findings remain under wraps

scim.ag

Two papers pin the introduction of smallpox on British colonists and suggest that Australia held far more people than previously believed. Learn more: https://scim.ag/3R2lLmf

Max Planck, a legendary pioneer of quantum mechanics and the 1918 Nobel laureate in physics, had two papers retracted decades after his death for reasons that remain mysterious. Learn more: https://scim.ag/4exoz3T

Congratulations to the teams at Palleon and Henlius, first patients dosed with B7H3-targeted sialidase immune therapy for ovarian cancer. Great partnership around glycan editing, an exciting new approach for immune modulation #glycotime www.businesswire.com/news/home/20...

It’s really frightening.

@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...

@sholtodavid.bsky.social Have you seen this WB from ThermoFisher? Still anti-p53 antibody, but another clone (MA-12648 instead MA5-12557). It also looks like that the band in lane 3 was rotated and reused in lane 4. Moreover, it seems that same band was used for the 2 different clones.

Drawing on a large-scale dataset of more than 12 million scientists, a new #SciencePolicyArticle reports that early-career scientists may be more inclined toward transformative breakthroughs, whereas seasoned researchers excel at synthesizing and extending existing knowledge. https://scim.ag/3PhW7JD

Aging and the narrowing of scientific innovation

Aging researchers and the removal of retirement policies yield decreased disruptive innovation in science

scim.ag

The more we learn about #glycotime, the more dramatic will be our revisions to textbooks on such basic principles as protein trafficking and organelle privileges www.nature.com/articles/s41...

Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability - Nature Cell Biology

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K...

nature.com

Our paid, Presidential Fellows Program offers the chance to work directly w/leadership across science, AI, finance, strategy, comms, & more while helping to shape real decisions. Open to both outstanding recent graduates & those with advanced degrees — apply now! bit.ly/4nwUi8f. 🧪