As an early-phase trialist, I never stop being amazed by the bravery & generosity of people who step forward into the unknown. Patients like Tracy don't just shape their own care; they open doors for everyone who follows. 🔬 So it means a great deal to share a 𝗴𝗹𝗼𝗯𝗮𝗹 𝗳𝗶𝗿𝘀𝘁 🌎... @mcrcnews.bsky.social

Oldham woman becomes world's first to receive new cancer therapy

Tracy Tomlinson was offered the clinical trial for ovarian cancer at The Christie hospital in Manchester.

bbc.co.uk

🚀 A major milestone for @manifest-cirrp.bsky.social. Launching our prospective recruitment represents a significant milestone since we launched in Q4 2024. In doing so, we'll have the opportunity to learn from every patient. @ukri.org @crick.ac.uk 📖 Read more in The Christie press release: 1/4

Sandbach man is the first in the UK to join landmark immunotherapy study

Mark England was diagnosed with bladder cancer in early December last year. He is the first patient to join the MANIFEST study, one of the largest immunotherapy studies in the country.

christie.nhs.uk

𝗠𝗔𝗡𝗜𝗙𝗘𝗦𝗧 is truly a team effort. 💡 Humbled to hear our very first patient share his perspective. Experiences like his will shape how we scale up & are already helping us learn how more. Watch this space. @manifest-cirrp.bsky.social 📰 As featured today in @theobserveruk.bsky.social 👇

‘It won’t help me, but it might help someone like me’ say...

Mark England says numb fingers help him play guitar as researchers hope to change how disease is treated by investigating why immunotherapy does not benefit all

observer.co.uk

🔬 Another fantastic 𝗠𝗮𝗻𝗰𝗵𝗲𝘀𝘁𝗲𝗿 𝗜𝗺𝗺𝘂𝗻𝗼-𝗢𝗻𝗰𝗼𝗹𝗼𝗴𝘆 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 (𝗠𝗜𝗢𝗡) meeting! Great to bring together colleagues from academia, NHS & industry to showcase Manchester-led immuno-oncology research, celebrate recent presentations at major international 🌍 conferences. @mcrcnews.bsky.social

Exciting times in Manchester. Major investment in the CRUK Manchester Institute with eight new groups, including new group leader positions in computational biology and AI www.cruk.manchester.ac.uk/about/new-fu... @cruk-mi.bsky.social

Engineer blood cancer to defeat it!👨‍🔬👩‍🔬 I'm hiring a Senior Scientific Officer at the CRUK Manchester Institute — using CRISPR to recreate the mutation combinations behind AML and MDS, and find where they're vulnerable. Hands-on. Apply 👇 @cruk-mi.bsky.social apps.cruk.manchester.ac.uk/recruitment/...

A great collaboration 🙌 between our Thoracic Oncology, and Advanced Immunotherapy and Cell Therapy teams at The Christie 🐝 - driven by our stellar Senior Clinical Research Fellows Federico Monaca and Rachel Woodford. Available #OpenAccess in 𝘛𝘩𝘦𝘳 𝘈𝘥𝘷 𝘔𝘦𝘥 𝘖𝘯𝘤𝘰𝘭 👇 @christielibrary.bsky.social

Therapeutic Advances in Medical Oncology@tamedoncol.bsky.social · last mo.

Cytokine release syndrome (CRS) isn’t just a challenge in hematologic cancers -it’s increasingly relevant in solid tumours. This review dives into mechanism-driven strategies for prevention and management. 📖 buff.ly/ZDar0oT #Oncology #Immunotherapy #CancerResearch #ClinicalInsights

🚀 We're building momentum with our RISE programme, and growing our team! Come join us as a 𝗧𝗿𝗮𝗻𝘀𝗹𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗧𝗲𝗰𝗵𝗻𝗶𝗰𝗶𝗮𝗻. Deadline 7th July 2026 👇 @uom-dcs.bsky.social @fbmh-uom.bsky.social @mcrcnews.bsky.social

Translational Research Technician:Paterson Building

jobs.manchester.ac.uk

Great to be in Porto 🇵🇹 for ASPIC International Congress. Looking forward to 2 days of science! Slightly shameless plug: if you’re interested in PhD, postdoc, clinician-scientist, group leader or Clinical Research Fellowship opportunities in Manchester, come say hello 👋 - I’d be happy to chat.

🧑‍🔬 Postdoc position available in our MRC-funded RISE team - Valletta/Lim. The successful candidate will lead a translational project using CODEX multiplex imaging to study CRS pathogenesis in bone marrow from CAR-T patients - working with clinicians, scientists & industry. Deadline 10 July👇

Research Associate:Oglesby Cancer Research Building, 555 Wilmslow Road, M20 4GJ

jobs.manchester.ac.uk

Featured on BBC News: #TeamManchester is growing. 🚀 Cancer Research UK Manchester Institute will be receiving an extra £6m a year in investment, creating 8️⃣ senior research roles: 4 group leaders, 2 senior group leaders & 2 clinician scientists. @cruk-mi.bsky.social www.bbc.co.uk/news/article...

Manchester cancer research lab's £6m extra annual cash boost

Cancer Research UK Manchester Institute says the extra cash will make a "huge difference" to its work.

bbc.co.uk

🚀 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗙𝗲𝗹𝗹𝗼𝘄𝘀𝗵𝗶𝗽 opportunities - come join us in Manchester! Looking to develop your career in Oncology? Interested in building a subspecialty interest? Keen to combine clinical excellence with research? Several exciting opportunities available at The Christie NHS Foundation Trust 👇

How do donated tissue samples help shape future cancer treatments? Our latest blog explores the work of the MCRC Biobank, which has collected more than 230,000 samples from nearly 30,000 patients to support cutting-edge cancer research. Read more: https://ow.ly/ozuS50Z5EsS

The MCRC Biobank: Turning Tissue Donations into Tomorrow's Treatments - Manchester Cancer Research Centre

Every year, thousands of cancer patients treated at The Christie NHS Foundation Trust, Manchester University NHS Foundation Trust and Northern Care Alliance NHS Foundation Trust choose to donate tissue samples to the Manchester Cancer Research Centre Biobank.

ow.ly

Almost 2️⃣ years in… Our MANIFEST AGM convened scientists, clinicians, patient partners & industry. Keynotes from Prof Levesque & Prof Rattray + Prof Turajlić setting the course ahead. Big thank you to all for continuing to believe in the vision; to tackle the hard questions in #CancerImmunotherapy.

💥 Really pleased to see this story finally out in @natcancer.nature.com. An elegant study built around a very cool concept. Huge congratulations to Tom Castro-Dopico, @reisesousalab.bsky.social and all colleagues involved - delighted to have played a small part in it the journey. @crick.ac.uk

Caetano Reis e Sousa@reisesousalab.bsky.social · 3mo ago

Delighted that our paper is out @natcancer.nature.com. Research led by Tom Castro-Dopico in partnership with Adendra Therapeutics reporting on a means to increase presentation of antigens from cancer cells. Read it for free at www.nature.com/articles/s43...

Nice celebration @reisesousalab.bsky.social of our recently published or in press papers. L-R: Tom Castro-Dopico, Oliver Schulz, @drjonlim.bsky.social and Mike Buck. See earlier and forthcoming posts for paper details.

🚨 We're looking for an Associate Director for Strategy & Partnerships — a pivotal leadership role that will help define how we connect, collaborate, and amplify our impact on a global stage of cancer research! Apply below by 26.05.2026! 👇 www.cruk.manchester.ac.uk/career/mi-26... Salary - ~£80,000

Fantastic 2 days in San Diego 🌴 for the inaugural C8 Early Career Investigators Symposium. Happy to represent #TeamManchester + connect with an inspiring group 🌍. A reminder that we’re not navigating academia alone - great to hear re: lessons learned & tips for future 🤝. @mcrcnews.bsky.social

#ESMOTAT26: Drug development in oncology is increasingly moving towards integrated strategies that consider tumour cells, their microenvironment and anatomical context. Read the Opinion by Jon Lim, FRCP PhD in the #ESMODailyReporter 📌 https://ow.ly/fFUx50YJxOP

🚨 Open for applications - Director of Scientific Core Facilities & Services! Shape the strategic future of our core facilities and work with leading experts on cutting-edge cancer discovery and translational research 🧑‍🔬🔬🧪 💷 ~£100,000 ⏰ 17.5.2026 Apply 👉 www.cruk.manchester.ac.uk/career/mi-26...

Tumour infiltrating lymphocyte (TIL) therapy is here to stay...but toxicity may be the real bottleneck. Most of it is not the TILs - it’s everything around them. We unpack this in our latest review. Available #OpenAccess - 𝘑 𝘐𝘮𝘮𝘶𝘯𝘰𝘛𝘩𝘦𝘳 𝘊𝘢𝘯𝘤𝘦𝘳 @sitcancer.bsky.social👇 🔗 jitc.bmj.com/content/14/4...

We're thrilled to see our Director, Samra Turajlić be awarded the Kidney Cancer Association Pieter De Mulder award for contributions towards the treatment of kidney cancer 🎉 Samra's research group is investigating how and why kidney cancer evolves to increase the success of treatment strategies 🧪

🚀 We’re hiring: 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗣𝗿𝗼𝗷𝗲𝗰𝘁 𝗠𝗮𝗻𝗮𝗴𝗲𝗿 𝗶𝗻 𝗜𝗺𝗺𝘂𝗻𝗼-𝗢𝗻𝗰𝗼𝗹𝗼𝗴𝘆 An exciting 🆕 role which sits at the heart of a highly collaborative & ambitious ecosystem spanning the Manchester Immuno-Oncology Network (MION) + the Advanced Immunotherapy and Cell Therapy (AICT) programme. 📩 Deadline 9th April 2026.

Next, master of dendritic cells Caetano has an update on dead cell recognition in the context of tumor immunity: We knew DC use exposed actin to gobble up dead cells. Here they show if you tether a model tumor antigen to actin, you get better anti-tumor immunity. Neat!!! doi.org/10.1038/s415...

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology

Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

doi.org

Cell therapy for solid tumours is advancing rapidly, but translation into patient benefit will depend on continued collaboration 🌍. 💡 Delighted to see this work come to fruition - thanks to all co-authors, for this thoughtful & collaborative effort. @haanenjohn.bsky.social #OpenAccess 👇

Advances in cell therapy for solid tumours: European perspective and future directions

Cell therapy has revolutionised the landscape of cancer treatment, with therapies such as Chimeric Antigen Receptor T cells (CAR-T cells), showing remarkable efficacy in haematological malignancies, a...

thelancet.com

Exciting new research from our Group Leader @sylvaindelaunay.bsky.social and Pierre Close at @universitedeliege.bsky.social shows how modifying a tRNA can alter the immune profile of #melanoma - exposing it to the #ImmuneSystem Read the full story here: www.cruk.manchester.ac.uk/news/new-res...

New Research: TRNA Modification Triggers Anti-tumour Immunity | Cancer Research UK Manchester Institute

New research has uncovered an unexpected way to stimulate the immune system against cancer: by subtly disrupting how tumour cells manufacture their proteins.

cruk.manchester.ac.uk

We have three exciting opportunities for you to join us for a fully-funded 4-year #PhD project here in #Manchester starting in October 2026 Find full details of all the projects on our website: www.cruk.manchester.ac.uk/phd-student-... Applications close 3rd April 2026

Fantastic inaugural national TIL Therapy Summit in Manchester with a stellar faculty ⭐. Great to welcome colleagues from across the UK & Europe for a day full of insightful discussions on the current landscape + future of TIL therapy. @mcrcnews.bsky.social

The Christie Institute for Cancer Education@christieinstitute.bsky.social · 5mo ago

This week we welcomed healthcare professionals, researchers, policy makers and industry partners from across the UK and internationally for the first national summit dedicated to TIL (tumour-infiltrating lymphocyte) therapy. Thanks to our speakers, delegates and partners who contributed to the day.

Do you have an impactful research idea? One that could improve care or advance science? Apply for the ESMO Leadership & Career Development Award, offering protected research time, leadership & communication training by 3 May 26 . 🔗https://ow.ly/Gicm50YqcbZ #Oncology #ESMOYOC

The Crick Postdoctoral Clinical Fellowship has been one of the most pivotal steps in my development as a clinical academic. The environment, mentorship, infrastructure, and scientific ambition at @crick.ac.uk are truly unparalleled. Strongly recommended! Deadline: 30th April 👇

The Francis Crick Institute@crick.ac.uk · 5mo ago

Are you a clinician looking for a fully-funded postdoctoral research opportunity? Check out our postdoctoral career development fellowships for clinicians, and see how you can join our vibrant community: www.crick.ac.uk/careers-and-...