Melanie McReynolds
@drohsopretty.bsky.social
Who needs social media? I have followers in real life. Assistant Professor and HHMI Hanna Gray Faculty Fellow at Penn State. Aging, Metabolism, and Faith-Based Science. Mississippi born and raised.
The gentle reminder I needed to continue to show up authentically in science! Grateful and overjoyed.
Hypothesis Fund@hypothesisfund.bsky.social · 4mo ago📣 Bold science alert! We're thrilled to announce our latest awardees who are pushing the boundaries of research in aging, regeneration, and bacterial resilience. bit.ly/HFAwardees Hear from the #HFScouts who championed these talented scientists👇 in our 🧵: 1/
📣 Bold science alert! We're thrilled to announce our latest awardees who are pushing the boundaries of research in aging, regeneration, and bacterial resilience. bit.ly/HFAwardees Hear from the #HFScouts who championed these talented scientists👇 in our 🧵: 1/
2/ Awardee @drohsopretty.bsky.social hypothesizes that aging is caused by a breakdown in metabolic communication 💬 between cells. Her work introduces a new conceptual layer to aging biology, and may be key to restoring metabolic aging. 🥳 Congrats Dr. McReynolds! 🙏 #HFScout @harmitmalik.bsky.social
Excited to share our lab’s latest contribution where we highlight a new development for a bifunctional enzyme that mitigates redox imbalance and lipotoxicity for the potential use as a treatment for metabolic disorders. www.nature.com/articles/s42...
A metabolic safety valve for reductive stress - Nature Metabolism
The glycerol-3-phosphate shuttle links redox balance to lipid synthesis, making the relief of reductive stress costly. Pan et al. rewire this circuit with a bifunctional enzyme that uncouples NAD⁺ reg...
nature.com
Huge congratulations to Dr. Abrar Alsaadi on successfully defending her dissertation! My first PhD graduate—an incredible milestone for her, for me, and for the McReynolds Lab. So proud of the scientist and leader she has become. Onwards and upwards.!
Driven by an experience familiar to many — watching parents age — HHMI Hanna Gray Fellow Melanie McReynolds wants to answer a fundamental question: How can we age healthier? The key may lie in better understanding NAD+ & how its levels decline as we grow older. Via @asbmb.bsky.social: bit.ly/45tDuHB
Huge congratulations to our ABRCMS 2025 award winners! 🏆✨ • Isaiah Diggs – Outstanding Poster Presentation • Lily Williams – Outstanding Poster Presentation So proud of the excellence, dedication, and growth these two have shown since joining my lab as freshmen. They shined on the national stage!
So proud — like the soccer mom type of proud— of my senior undergrad Isaiah Diggs for winning a poster award at SACNAS!
Today's #TBT post celebrates 120 years of the Journal of Biological Chemistry! The first issue of JBC was published in Oct. 1905. Here's the ASBMB Membership Committee w/a copy of that first issue! It was a fun moment looking back as the membership committee looks to the future. asbmb.org/membership
Thank you to everyone who joined our recent committee meeting! #ASBMBJournals #JbiolChem 📸 Committee members here on #Bluesky: @chifungleephd.bsky.social, @marinaholz.bsky.social & @drohsopretty.bsky.social.
American Society for Biochemistry and Molecular Biology@asbmb.bsky.social · 10mo agoToday's #TBT post celebrates 120 years of the Journal of Biological Chemistry! The first issue of JBC was published in Oct. 1905. Here's the ASBMB Membership Committee w/a copy of that first issue! It was a fun moment looking back as the membership committee looks to the future. asbmb.org/membership
Excellent first day at @pennstateuniv.bsky.social for the Marker lectures hanging out with science celebrities @nicoleacrowley.bsky.social @drohsopretty.bsky.social @symbionticism.bsky.social plus several more folks I was too shy to ask for selfies
A great collaboration with the @drohsopretty.bsky.social lab examining the gut-liver axis: the enteroendocrine cells, enterohormones, metabolites, and lipid changes in MASLD and MASH models.
bioRxivpreprint@biorxivpreprint.bsky.social · 11mo agoMetabolomic, Lipidomic, and Enterohormone Changes in the Progression from MASLD to MASH https://www.biorxiv.org/content/10.1101/2025.09.16.676598v1
In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator. Forever grateful to past and present members of my lab for helping me accomplish this dream.
