Learning what happens after early life insults #IBNSSouthAfrica

Very honoured to have been included in this latest cohort of CAN and CIHR-INMHA Brain Star awardees! Congratulations to all of the other winners!

Canadian Association for Neuroscience@canacn.bsky.social · 3mo ago

CAN and CIHR-INMHA are very proud to announce the winners of the 2025 Brain Star awards. See all their profiles here: can-acn.org/congratulati...

Continued learning, sociability, and exercise promote resilience to memory impairment in AD These factors also increase the activity of the RSC, an early site of dysfunction in AD Here we perform an RSC deep-dive to examine this interaction (PV and PNNs matter!) www.jneurosci.org/content/46/9...

Environmental Enrichment Preserves Retrosplenial Parvalbumin Density and Cognitive Function in Female 5xFAD Mice

The rate of cognitive decline in Alzheimer's disease (AD) varies considerably from person to person. Numerous epidemiological studies point to the protective effects of cognitive, social, and physical...

jneurosci.org

New review building on findings from my MSc thesis! Here we discuss the role of dopamine in overcoming boundary conditions for memory reconsolidation. doi.org/10.1016/j.ne...

A little late posting this, but I defended my PhD thesis earlier this year! Big thanks to Jonathan Epp for his mentorship and support over the years - I can’t recommend his lab enough 🇨🇦 Also very excited to share that I’ve started a postdoc at @inmed.bsky.social with Rosa Cossart! 🇫🇷

As our graduate program deadline approaches, we are recruiting motivated students to join our team. See details below:

Canadian Association for Neuroscience@canacn.bsky.social · 11mo ago

New ad: Graduate (MSc / PhD) Student Positions – Neurophysiology of Autism Mouse Models – University of Calgary can-acn.org/graduate-msc... @deryasargin.bsky.social #neurojobs

New ad: Graduate (MSc / PhD) Student Positions – Neurophysiology of Autism Mouse Models – University of Calgary can-acn.org/graduate-msc... @deryasargin.bsky.social #neurojobs

You KNOW you've arrived, mainstream, when your invention is turned into an open source asset!🧠🧪 Kudos @deryasargin.bsky.social www.eneuro.org/content/12/6... @cate-cholamine.bsky.social @mathiasvschmidt.bsky.social @zenbrainest.bsky.social @sfn.org #StressNeurobiology @carmensandi10.bsky.social

My first paper in the Sargin Lab 🥳 so grateful to have been able to work on this project @deryasargin.bsky.social @dterstege.bsky.social @jonathanepp.bsky.social

SfN Journals@sfnjournals.bsky.social · last yr.

#eNeuro | An Open-Source and Highly Adaptable Rodent Limited Bedding and Nesting Apparatus for Chronic Early Life Stress vist.ly/3n8f76m

A research team led by Dr. Jonathan Epp and Dr. Derya Sargin at the University of Calgary, funded by Brain Canada and Women’s Brain Health Initiative (WBHI), has identified a promising target for new Alzheimer’s disease treatments. bit.ly/45atSCf

Fantastic new paper on Alzheimer's Disease from my colleague @deryasargin.bsky.social and her team! www.science.org/doi/10.1126/...

Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease

Altered function, connectivity, and survival of parvalbumin-expressing neurons in the retrosplenial cortex in Alzheimer’s disease.

science.org

Female brain holds the key to understanding Alzheimer’s disease. Epp-Sargin lab collaboration led by @dterstege.bsky.social featuring @liisagalea.bsky.social is out in Science Advances. We uncover the mechanisms that make females more vulnerable to Alzheimer’s - in mouse models and human brains 🧠

Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease

Altered function, connectivity, and survival of parvalbumin-expressing neurons in the retrosplenial cortex in Alzheimer’s disease.

science.org

Dylan Terstege@dterstege.bsky.social · last yr.

🚨New paper from the Epp and Sargin Labs!🚨 We identified early sex- and region-specific impairments to parvalbumin interneurons (PV-INs) during Alzheimer’s Disease (AD) pathogenesis www.science.org/doi/10.1126/... Simplified highlights below: 🧵/15

🚨New paper from the Epp and Sargin Labs!🚨 We identified early sex- and region-specific impairments to parvalbumin interneurons (PV-INs) during Alzheimer’s Disease (AD) pathogenesis www.science.org/doi/10.1126/... Simplified highlights below: 🧵/15

Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease

Altered function, connectivity, and survival of parvalbumin-expressing neurons in the retrosplenial cortex in Alzheimer’s disease.

science.org

The new issue of Science Advances (open-access) has multiple papers on women's health. These 2 are related to menopause, hormone replacement and brain health www.science.org/toc/sciadv/c...

Our work on the effect of SSRIs on brain metabolic activity, tau levels and cognition is out. Another study led by amazing-Dylan Terstege (now Dr. Terstege). alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

SSRIs reduce plasma tau and restore dorsal raphe metabolism in Alzheimer's disease

INTRODUCTION Tau pathology impacts neurodegeneration and cognitive decline in Alzheimer's disease (AD), with the dorsal raphe nucleus (DRN) being among the brain regions showing the earliest tau pat...

alz-journals.onlinelibrary.wiley.com