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Duerkop Lab

@duerkoplab.bsky.social

Phages and other mobile genetic elements of bacteria | Microbiome and pathobionts | Associate Professor CU-Anschutz | Microbiology Program Director CU-Anschutz | https://www.duerkoplab.org/

5 Posts954 Follower431 Folgt
Manuel Kleiner@manuelkleiner.bsky.social · 4w ago

The type and amount of bacterial DNA carried by virus-like particles in the gut microbiome is simply mind-boggling. Amazing work by PhD candidate Jessie Maier in my group and collaborators @duerkoplab.bsky.social and Ben Callahan www.biorxiv.org/content/10.6...

Perturbations shift the composition of bacterial DNA carried by virus-like particles in the murine gut microbiome

Horizontal gene transfer (HGT) is a driving force in microbial evolution that allows community members to rapidly evolve to cope with environmental stressors and competition. Despite the importance of...

biorxiv.org

Kimberly Kline 🏔@kimingeneva.bsky.social · 6mo ago

Lactic acid lover? Check out @ronni.bsky.social 's new work in @cp-cellhostmicrobe.bsky.social showing how Enterococcus faecalis-derived LA suppresses macrophage activation, in turn promoting bacterial persistence and polymicrobial wound infection in vivo. www.sciencedirect.com/science/arti...

Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections

Macrophage activation is essential for innate immunity and antimicrobial defense. We show that Enterococcus faecalis suppresses macrophage activation …

sciencedirect.com

Peter Dougherty@peterdoug.bsky.social · 7mo ago

Bacteriophages are normally classified as either virulent or temperate. Reality is, of course, more complicated! Here we show many bacterial isolates contain non-temperate phages that can persist through restreaking. Thanks to all co-authors for such a great collaboration!

@emggroupucph.bsky.social · 7mo ago

[1/3] Is your favorite bacterial isolate hiding a surprise lytic virus with a VERY different lifestyle? Finally I can proudly say that our paper on persistent phages is out in Nature Microbiology. rdcu.be/eWJEp. Well done @peterdoug.bsky.social

Willem van Schaik@wvschaik.bsky.social · 9mo ago

Delighted that our review on resistance to last-resort antibiotics in Enterococci has been published in FEMS Microbiology Reviews academic.oup.com/femsre/advan... (accepted manuscript version) TL;DR: the Enterococci are really good at evolving resistance to antibiotics in new and creative ways.

Resistance to last-resort antibiotics in enterococci

Abstract. The genus Enterococcus comprises a diverse group of species, many of which are commensal members of the gut microbiota of humans and animals. The

academic.oup.com

José R Penadés@jrpenades.bsky.social · 10mo ago

Our latest work reveals that arbitrium phages cross-communicate across species! These tiny viruses “listen” to signals from others, coordinating lysis-lysogeny decisions across species. Original idea from @albertomarina.bsky.social and, as usual, he was right. www.biorxiv.org/content/10.1...

Phages communicate across species to shape microbial ecosystems

Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...

biorxiv.org

Joshua Weitz@joshuasweitz.bsky.social · last yr.

How bad will it be? Catastrophic. Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come. But, this is the WH's *proposed* budget. Speak up now before it is too late. (inflation adjusted $-s below)

NSF, NASA and NIH budgets per year, inflation adjusted from 2000-2025 along with the proposed cuts. NSF includes research component only. Massive cuts across all sectors, well below support spanning 25 years.
Dr. David Miller 🏳️‍🌈@davidimiller.bsky.social · last yr.

10/ And to reiterate a key point: CONGRESS 👏 SETS 👏 BUDGET 👏 LEVELS Today's update is called a **request** for a reason. And Congress should reject it. History provides optimism:

Dr. David Miller 🏳️‍🌈@davidimiller.bsky.social · last yr.

So: In 2017, Congress made this happen: NIH: Proposed 22% cut --> 9% increase NSF: Proposed 11% cut --> 4% increase NOAA: Proposed 16% cut --> 4% increase Obviously, 2025 is not 2017. A lot is diff now. But still: 💰 Congress, not WH, sets budgets. 📞 Public support & calls to Congress matter.

Joshua Weitz@joshuasweitz.bsky.social · last yr.

Whoa... This resignation should alarm scientists, leaders, and elected officials across the aisles. For over 70 years, NSF has promoted science, advanced an innovation economy, and supported the national defense. America's future depends on federal investment in NSF, NIH + beyond.

Science Magazine@science.org · last yr.

Exclusive: The director of the National Science Foundation announced his resignation today, 16 months before his 6-year term ends, in a letter to staff obtained by Science. scim.ag/42vc3fn

Mike Lee@astrobiomike.org · last yr.

Biology is so cool - P. syringae produces syringafactin, which is deacylated by amoebae - Deacylated syringafactin binds to CraR, triggering amoebicidal pyrofactin synthesis - Cra allows P. syringae to infect Arabidopsis thaliana in the presence of amoebae #MicroSky

A chemical radar allows bacteria to detect and kill predators

Pseudomonas syringae can detect and kill microbial predators via a chemical radar (Cra), which also allows the bacterium to infect plants despite predation pressure.

cell.com

Nanami Kubota@nanamikubota.bsky.social · last yr.

Preprint out! Bacteria w/ hyper-replicative filamentous phage lead to overnight emergence of cheater phages. Bacteria w/ both phages can outcompete wildtype, then rapidly lose phage via a phage Tragedy of the Commons @shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...

Filamentous cheater phages drive bacterial and phage populations to lower fitness

Many bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...

biorxiv.org

Gemma C. Atkinson@gemmaatkinson.bsky.social · last yr.

Please spread the word! We have an opening in the Atkinson lab for a post-doc with a focus on the molecular mechanisms of microbial immune systems. Can be a fully computational or experimental or hybrid project. Read more and apply here: lu.varbi.com/en/what:job/... #phage #bioinformatics

Postdoctoral research fellow with a focus on the molecular mechanisms of bacteriophage-host interactions

Description of the Workplace In the Atkinson lab we are interested in making discoveries about protein function and structure, with a focus on bacterial immune system components that protect against b

lu.varbi.com

Michael Baym@baym.lol · last yr.

Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!

Fernando Rossine@fernpizza.bsky.social · last yr.

I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! (1/n) www.biorxiv.org/content/earl...

Dr. Michael D. L. Johnson@copperbae.bsky.social · 2y ago

We must have an unprecedented amount of grace, collaboration, and support for our colleagues and trainees right now. We will get out of this mile one. It won’t make the run easier, but we will settle in and we will finish. I wrote this because I needed to hear it. I hope it was helpful to you.