The countdown to the RepliFate Final Conference is officially on, and the scientific programme is now live: replifate.eu/event/intern... #Munich2026 #MSCA #LifeScience #DNAReplication #GenomeStability #Chromatin

Events for June 2026

Monday, 6th July 2026 09:00 09:10 Welcome & Opening Remarks Organising committee Session 1. Replication initiation and chromatin feature (1/2)  Chair: Juan Méndez (Spanish National Cancer Re...

replifate.eu

⏰ Missed the deadline? We've got you covered! Registration for the #RepliFate Final Conference has been extended until 15 June 2026. - 6 & 7 July | Helmholtz Munich - Outstanding speaker lineup & 12 MSCA fellows Register now: replifate.eu/event/meetin...

Events for June 2026

06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

replifate.eu

There's also a chance for YOU to share your science. 🔬 Registration closes 5 June 2026. 👉 Details + registration link: replifate.eu/event/meetin... #DNAReplication #GenomeStability #Chromatin #MolecularBiology #MSCA #HorizonEurope #RepliFate

Events for May 2026

06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

replifate.eu

Highlights from the Egmond DNA Repair meeting: Julien shared our work, Sidak and Stella brought nice posters—and both got invited to give short talks. And the cherry on top? Stella won the Best Poster Prize, congrats! A pretty great week for the lab 🏆

We go live!!! Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social @replifate.bsky.social @epicrossborders.bsky.social replifate.eu/event/meetin...

Events for February 2026

06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

replifate.eu

'Just bypass it: mechanisms of DNA damage tolerance' takes a fresh look at how cells replicate damaged DNA. The review, by RepliFate-affiliated @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social), revisits lesion bypass in light of recent advances DOI: 10.1016/j.tibs.2025.07.004

Our first bachelor student successfully defended her thesis! An impressive piece of lab work paired with a clear, engaging defence and discussion. Congrats! Many thanks to Panos Galanos (SDU) for serving as external examiner and for the thoughtful evaluation. Welcome to the academic club, Amélie!

The last EDRA webinar of the year is today at 4 pm with Julian Stingele presenting the role of RNA damage in chemotherapy, followed by Andre Bortolini Silveira on BER and MMR converge, and Nicola Pietro Montaldo on Mitochondrial DNA Repair and Parkinson's Disease @edra-webinars.bsky.social

Don’t miss it! The 12th Conference on Responses to DNA Damage will take place in Egmond aan Zee from 19–24 April 2026. 📅 Registration is open! Deadline for abstracts: Jan 10, 2026. More details & provisional program here: dnarepairmeeting-egmond2026.com

Fascinating paper from Krietenstein, Groth & Lukas groups showing how cells can repair a DSB, but its 'echo' can persist leading to postrepair chromatin fatigue

The Groth lab@grothlab.bsky.social · 9mo ago

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

Excited to have contributed to this new @cp-molcell.bsky.social paper on how PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed. A big congrats to Jonas for driving this work forward, great to see the results out! 👉 10.1016/j.molcel.2025.09.006

BRIC Day with the theme collide across each other — all about sparking new intra-institute collaborations. Kickoff with a keynote from Rasmus Rabøl (Klifo) and a buzzing poster session full of science-in-the-making! @bric-ucph.bsky.social

Today we swapped pipettes for putters. Day 2 retreat highlight: realizing that hitting the fairway is way harder than hitting a replication fork 😅

Off to Nord Sjælland with the Miller lab @tcr-miller.bsky.social for our joint retreat! Exciting brainstorming, bonding, and a little hygge ahead. First challenge: design your next @natureportfolio.nature.com article 🚀

What makes #cshldnarep special isn’t just the cutting-edge, top-notch science; it’s the chance to meet the authors of the papers we build on every day, exchange ideas, and feel part of this community. Heading home exhausted, grateful, full of ideas and renewed motivation to push my project forward!

Our PhD student @martaolivasantiago.bsky.social and postdoc @amitash.bsky.social presented their posters on #cshldnarep, turning data into an insightful dialogue. Huge thanks to everyone who stopped by our poster!

This week we’re at CSHL #cshldnarep where the DNA replication & genome maintenance community has gathered for a week of science, discussions, and late-night brainstorming.

Sometimes DNA replication hits a 🛑 roadblock. Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact. That’s the focus of our new review in @cp-trendsbiochem.bsky.social: “Just bypass it: mechanisms of DNA damage tolerance” 🔗 doi.org/10.1016/j.ti...

New cool research alert! Tita Sixma #RepliFate lab uncovered the preferred exo-cleavage mechanism by which USP1/UAF1 can cleave ubiquitin chains on polyubiquitinated PCNA and temporarily enrich for monoubiquitinated PCNA. Read the full study: doi.org/10.1038/s414...

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications

DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...

doi.org

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

Just published! Lecona (@emlecona.bsky.social ) & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication VCP/p97 = checkpoint gatekeeper! Read the full study: doi.org/10.1038/s414...

DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication - Nature Communications

The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex from chromatin, preventing exces...

doi.org

🎉 Congratulations to SUND's new professors! The Faculty of Health and Medical Sciences, @ucph.bsky.social celebrated 23 newly appointed professors. Through their dedicated work, they contribute every day to the development of the university, the healthcare system, and society at large.

🌿 Off to Hillerød for the 2025 MoMeD Summer School! Our PI Julien Duxin -as head of the MoMeD PhD Programme at @ucph.bsky.social- joins our PhD students and many others for 2 packed days of science, networking, and inspiration. Looking forward to connecting and exchanging ideas across fields!

Frogs in the lab? Yep! 🐸 This week, RepliFate PhD students are diving into the Xenopus egg extract system at the @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social) -where test tubes meet frog magic to unravel the mysteries of DNA replication and genome integrity.

Our lab’s a little more crowded (and a lot more curious) this week! 🧠🐸 We’re thrilled to welcome @RepliFate students for a hands-on course in Xenopus egg extracts. They're diving into the Xenopus world and learning how this powerful system helps us explore DNA replication and genome stability.

🎯 A tenure-track group leader position in translational cancer research is now open at Finsen Laboratory. Come join an excellent and friendly research environment combining both the Rigshospitalet and the KU @ucph.bsky.social affiliated groups candidate.hr-manager.net/ApplicationI...

Tenure-track Research Group leader position in translational cancer research at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital

A group leader position at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital is open for appointment as soon as possible. The position is av

candidate.hr-manager.net

Chromosome Biology Club is back today! Join us for two exciting talks: 🧬 Christian Nielsen (CCS/ICMM) on the distinct roles of condensins I & II in mitotic chromosome mechanics 🧬 Judit Pilmark (BRIC) on mutational signatures linked to NER deficiency Starting at 4.45 pm Followed by pizzas and beer

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ @natcomms.nature.com BRCT domain in recruitment and activity of two Pol X members in NHEJ: a unified model for the interaction of Pol X with Ku70/80. www.nature.com/articles/s41...

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ - Nature Communications

The molecular basis for the enrollment of X family DNA polymerases in non-homologous end joining (NHEJ) is unclear. Here the authors elucidate the structure of Pol λ within the DNA-PK long-range compl...

nature.com

The FEBS | EMBO Women in Science Award aims to highlight the major contributions made by female scientists to #LifeSciences research. Winners of the award are inspiring role models for future generations of #WomenInScience Nominate a scientist by 15 May: www.embo.org/the-embo-com... 🧪

FEBS|EMBO Women in Science Awardees – Nominate for the Women in Science Award – EMBO

Nominees should be female scientists working in an EMBC Member State or FEBS member country, who have made outstanding contributions to life sciences research and significantly advanced our…

embo.org

New preprint from the lab @kaelamakins.bsky.social Genetic interactions between 53BP1-RIF1 and DNA-PKcs for DSB repair outcomes. www.biorxiv.org/content/10.1...

53BP1/RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes.

DNA double strand breaks (DSBs) are the effective lesion of cancer radiotherapy and induce gene editing. 53BP1 accumulates at DSBs and is implicated in end joining (EJ) repair, but its influence on DS...

biorxiv.org