Dr David Vauzour
@dvauzour.bsky.social
Associate Professor UEA, Norwich Medical School. Investigating the health benefits of #food #bioactives on brain functions including the #gut-#brain axis
📝 Menopause HRT cuts women’s dementia risk – but only if it’s started early enough. Women who take hormone replacement therapy (HRT) are less likely to get Alzheimer’s disease, a study of more than 180,000 UK Biobank participants has revealed. Prof Anne Marie Minihane, @uniofeastanglia.bsky.social
!["I think [our research] does add to the evidence that the benefits of HRT seem to outweigh the risks – and the importance of starting early.” Professor Anne Marie Minihane, University of East Anglia](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:qdvkg4pmhr3sxyrzt5y5vxye/bafkreihym457xxho4bbrwrjdfzxqq2tyhrvqi5wcmgghrowuz4m4vped7y)
Led by Prof Anne-Marie Minihane, Director of the Norwich Institute for Healthy Ageing, the research suggests that HRT could have protective benefits for some groups, highlighting the potential for more personalised approaches to prevention. @healthuea.bsky.social @ueamedical.bsky.social
Our new research in Alzheimer’s & Dementia explores whether some women may be more responsive to HRT in relation to dementia risk. doi.org/10.1002/alz.... #Dementia #Alzheimers #Menopause #HRT
doi.org
Looking forward to speaking at the 11th Congress of the International Human Microbiome Consortium (IHMC 2026), taking place June 3–5, 2026, in Seoul, Korea The program brings together an outstanding line-up of speakers and promises exciting discussions on the latest advances in microbiome science.
IHMC 2026 SEOUL
IHMC 2026 SEOUL 사이트입니다.
ihmc2026seoul.com
Dr David Vauzour, from @ueamedical.bsky.social has been the lead researcher on a study that has found that a blood test could help identify people at higher risk of cognitive decline years before a traditional diagnosis is possible. Read more: https://bit.ly/4v12Wz6 #BloodTest #ResearchMatters
Excited to present our latest paper, led by @dvauzour.bsky.social and Dr Emily Connell. We have promising data showing that a pattern of microbe-derived metabolites can distinguish early stage cognitive impairment in humans. doi.org/10.1080/19490976.2026.2649487 🧪🧠🦠 #microbiome #gutbrainaxis
Circulatory dietary and gut-derived metabolites predict early cognitive decline
A key component of disease prevention is the identification of at-risk individuals. Microbial dysbiosis in the early stages of cognitive decline and Alzheimer's disease (AD) and can modulate the le...
doi.org
Full article: A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice www.tandfonline.com/doi/full/10....
A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice
Alzheimer's disease (AD) is projected to increase in prevalence, heightening the need for strategies to alleviate its neuropathological burden. The bioactive constituents of a Mediterranean-style d...
tandfonline.com
What if a simple blood test could help detect early cognitive decline? Our latest study shows that microbe-derived metabolites shaped by the gut microbiome can distinguish early-stage cognitive impairment with promising accuracy.
Circulatory dietary and gut-derived metabolites predict early cognitive decline
A key component of disease prevention is the identification of at-risk individuals. Microbial dysbiosis in the early stages of cognitive decline and Alzheimer's disease (AD) and can modulate the le...
tandfonline.com
Still time to take part in this study!
Dr David Vauzour@dvauzour.bsky.social · 11mo ago✅NOW RECRUITING !!! If you are aged 18-40, live in Norwich or surrounding areas and want to test your #brain function, then see below and take part in the REACT study assessing the impact of #ginseng on #attention and #memory. @ueamedical.bsky.social @uniofeastanglia.bsky.social
I’m speaking at the Alzheimer’s Research UK Conference 2026 on How Microbial Metabolites and Polyphenols Shape Cognitive Ageing and Alzheimer’s Risk Will I see you there? Register here: Registration information - Alzheimer's Research UK #ARUKconf; @alzheimersresearchuk.org;
Full article: A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice www.tandfonline.com/doi/full/10....
tandfonline.com
Still time to take part in this study!
Dr David Vauzour@dvauzour.bsky.social · 11mo ago✅NOW RECRUITING !!! If you are aged 18-40, live in Norwich or surrounding areas and want to test your #brain function, then see below and take part in the REACT study assessing the impact of #ginseng on #attention and #memory. @ueamedical.bsky.social @uniofeastanglia.bsky.social
Very pleased this is now published - led by Dr Emily Connell & @dvauzour.bsky.social, we show that a Mediterranean diet-inspired supplement can improve disease signs in an Alzheimer's mouse model, acting via the gut microbiota www.tandfonline.com/doi/full/10.... 🧪🧠 #gutbrainaxis #meddiet
A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice
Alzheimer's disease (AD) is projected to increase in prevalence, heightening the need for strategies to alleviate its neuropathological burden. The bioactive constituents of a Mediterranean-style d...
tandfonline.com
Our latest paper is online! Here we report that a novel #Mediterranean diet-inspired supplement promotes a significant reduction in hippocampal #amyloid deposits and #neuroinflammation through the modulation of the #microbiota #gut-brain axis. www.tandfonline.com/doi/full/10....
A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice
Alzheimer's disease (AD) is projected to increase in prevalence, heightening the need for strategies to alleviate its neuropathological burden. The bioactive constituents of a Mediterranean-style d...
tandfonline.com
✅NOW RECRUITING !!! If you are aged 18-40, live in Norwich or surrounding areas and want to test your #brain function, then see below and take part in the REACT study assessing the impact of #ginseng on #attention and #memory. @ueamedical.bsky.social @uniofeastanglia.bsky.social
A great collaboration with the @International Network for Evidence on Phytochemicals, Biotics for Human Health. A must read systematic review and meta-analysis on the role of #anthocyanins and anthocyanins-rich #foods on #cognitive function link.springer.com/article/10.1...
The effect of anthocyanins and anthocyanin-rich foods on cognitive function: a meta-analysis of randomized controlled trials - GeroScience
The rising prevalence of cognitive disorders highlights the urgent need for effective prevention strategies and therapeutic interventions. While adherence to a balanced diet has been associated with a...
link.springer.com
How does your Christmas Dinner shape your gut, brain and immunity? 🎄🍽️ Join us for Feast for Thought – a festive deep dive for all with short talks and questions on food & health! 📅 11th Dec, 7pm-8pm 🎟️ Book now: feast-for-thought.eventbrite.com #GutHealth #BrainFood #ChristmasDinner
🚨 Research Fellow Opportunity 🚨 Join @uniofeastanglia.bsky.social & @quadraminstitute.bsky.social to explore the Brain-Gut Axis. 📍 Norwich Medical School ✅ £48,822–£56,535 📅 Apply by 1 Dec Lead pioneering research at the neuroscience–microbiome interface. 👉 vacancies.uea.ac.uk/vacancies/18...
✅NOW RECRUITING !!! If you are aged 18-40, live in Norwich or surrounding areas and want to test your #brain function, then see below and take part in the REACT study assessing the impact of #ginseng on #attention and #memory. @ueamedical.bsky.social @uniofeastanglia.bsky.social
I enjoyed contributing to the @ilsieurope.bsky.social Healthy Ageing Task Force. Leonie and Thomas have done a great job summarising workshop findings on what's needed to develop nutritional interventions that support healthy ageing. @dvauzour.bsky.social @drsimonmcarthur.bsky.social
Building a roadmap to nutrition for Healthy Ageing: a brief report on the ILSI Europe Healthy Ageing Task Force
At the end of October 2024, ILSI Europe brought together industry and academic experts from different fields to identify research gaps and challenges …
sciencedirect.com
The effects of inorganic nitrate and inulin co-ingestion on circulating metabolites and blood pressure in young adults: A pilot double-blind randomised crossover trial | Gut Microbiome | Cambridge Core - www.cambridge.org/core/journal...
The effects of inorganic nitrate and inulin co-ingestion on circulating metabolites and blood pressure in young adults: A pilot double-blind randomised crossover trial | Gut Microbiome | Cambridge Cor...
The effects of inorganic nitrate and inulin co-ingestion on circulating metabolites and blood pressure in young adults: A pilot double-blind randomised crossover trial
cambridge.org
A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the Gut-Sleep-Brain Axis randomised, double-blind, placebo-controlled pilot study https://www.medrxiv.org/content/10.1101/2025.02.20.25322405v1
Very pleased to see this paper out! A great collaboration with colleagues @exeter.ac.uk Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and APOE4 genotype academic.oup.com/pnasnexus/ar... @ueamedical.bsky.social
Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and APOE4 genotype
Abstract. Apolipoprotein E4 (APOE4) genotype and nitric oxide (NO) deficiency are risk factors for age-associated cognitive decline. The oral microbiome pl
academic.oup.com
14th INTERNATIONAL GUT MICROBIOLOGY SYMPOSIUM - 3-5 JUNE 2025 gutmicrobiology-2025.symposium.inrae.fr
IGMS2025
Home Page
gutmicrobiology-2025.symposium.inrae.fr
Nice write-up of our work from NTU's press office. @drsimonmcarthur.bsky.social @dvauzour.bsky.social
Toxin in blood of kidney disease patients could contribute to stroke risk, study suggests
Scientists have revealed that a toxin found in the blood of patients with chronic kidney disease (CKD) damages the body’s protective blood–brain barrier, likely contributing to the risk of stroke.
ntu.ac.uk
Over 7M people in the UK are estimated to live with #CKD. Researchers at #COIRM found a #gut #microbiome toxin in #CKD patients, p-cresol sulfate, damages the blood-brain barrier risking stroke & cognitive decline, but promising drugs may block this. More here: www.tandfonline.com/doi/full/10....
Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor
The gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence ind...
tandfonline.com
Simon McArthur@drsimonmcarthur.bsky.social · 2y agoBrand new paper from our group! www.tandfonline.com/doi/full/10.... with @bugsinyourguts.bsky.social, looking at the role of the #gutbrainaxis and the #bloodbrainbarrier in #chronickidneydisease, and how we could protect it. Only started the work in 2016 - I blame (hand waves) everything... 1/5
Just landed here from Twitter/X! 🚀 Time to rebuild my followers/following list. If u’re into microbiome science like me, let’s connect and grow a refreshed community! 🔁 Please RT & ❤️ this post so we can gather all the microbiome enthusiasts and scientists in one place. #MicrobiomeScience #Networking
New translational study from @bugsinyourguts.bsky.social and @drsimonmcarthur.bsky.social (at QMUL) showing how a microbiome-associated metabolite implicated in chronic kidney disease affects the blood–brain barrier. #microbiomesky
Professor Lesley Hoyles@bugsinyourguts.bsky.social · 2y agoDelighted to see this out, after a 2-year-long review process that left @drsimonmcarthur.bsky.social and I wondering what we'd done to upset the reviewing gods. #microbiomesky #gutbrainaxis www.tandfonline.com/doi/full/10....
🧵 on our (@drsimonmcarthur.bsky.social) work showing the mechanism through which the microbiome-associated metabolite p-cresol sulfate damages the blood-brain barrier in chronic kidney disease (CKD). #microbiomesky #gutbrainaxis
Professor Lesley Hoyles@bugsinyourguts.bsky.social · 2y agoHuge thank you to David Vauzour at UEA for quantifying pCS in patient samples, and colleagues from The William Harvey Research Institute for providing us with patient samples. Systems-level microbiome research only works when it's collaborative.
Brand new paper from our group! www.tandfonline.com/doi/full/10.... with @bugsinyourguts.bsky.social, looking at the role of the #gutbrainaxis and the #bloodbrainbarrier in #chronickidneydisease, and how we could protect it. Only started the work in 2016 - I blame (hand waves) everything... 1/5
Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor
The gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence ind...
tandfonline.com