Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU
@arom-ntu.bsky.social
Based at Nottingham Trent University's Clifton Campus in the UK. Microbiology. Phage and plasmid biology. Microbiome. Host–microbe interactions. Pathogen evolution. Genomic epidemiology. Antimicrobial resistance. https://www.arom-ntu.net/
Congrats to my PhD student Rachael Duodu on having her paper published! www.microbiologyresearch.org/content/jour...
The Omp85 family protein, TamA, exhibits characteristics of a suitable drug target against Pseudomonas aeruginosa
The outer membrane (OM) of Gram-negative bacteria is crucial for cell stability and virulence and acts as a permeability barrier. The biogenesis, assembly and regulation of proteins in the OM are, the...
microbiologyresearch.org
Lots of microbiology-related activities organised by @arom-ntu.bsky.social members at the Festival of Science and Curiosity in Nottingham.
Congratulations to former MRes students Mia Horton and Yashwani Malik on their new publication with @davidnegus.bsky.social, characterizing novel phages infecting Serratia spp. academic.oup.com/jambio/advan... #microsky @mohamedeladawy.bsky.social @bugsinyourguts.bsky.social
Characterization of two novel bacteriophages infecting clinical isolates of Serratia spp. and therapeutic efficacy in a Galleria mellonella model of infection
AbstractAIMS. This study aimed to isolate virulent bacteriophages (phages) with the capacity to lyse clinical strains belonging to the genus Serratia. Furt
academic.oup.com
A new preprint from my group, representing the PhD work of Rachael Duodu. Thanks to @bugsinyourguts.bsky.social for transcriptomics analysis!
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · last yr.The Omp85 family protein, TamA, exhibits characteristics 1 of a suitable drug target against Pseudomonas aeruginosa https://www.biorxiv.org/content/10.1101/2025.09.16.676292v1
Congratulations to Rachael Duodu on the first preprint from her PhD work, under the supervision of @jackcleo.bsky.social!
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · last yr.The Omp85 family protein, TamA, exhibits characteristics 1 of a suitable drug target against Pseudomonas aeruginosa https://www.biorxiv.org/content/10.1101/2025.09.16.676292v1
📢 We offer a fully funded 4-year #PhD position to work on tick #microbiota 🦠 dynamics using #genomics 🧬 at @irec-csic-uclm.bsky.social, supervised by @sdiazsanchez.bsky.social. For requisites and contact info, please check 👇 www.irec.es/noticias/pro...
This new review by Anne L McCartney and Lesley Hoyles examines the often overlooked role of Klebsiella bioactives in host-microbiota dynamics. 🔗 Access the full article here: doi.org/10.1530/MAH-24-0011
On our way to @mgeworkshop.bsky.social for @lotox.bsky.social to present later. Looking forward to some amazing talks! @arom-ntu.bsky.social #mgeworkshop
I am Honoured to have received the 2nd Prize at NTU's ⭐️ STAR (Science & Tech Annual Research) Conference! Special thanks to my supervisors @conmeehan.bsky.social @blackpassiflora.bsky.social and collaborators @danwhiley.bsky.social @Kate Cox for the incredible support. @arom-ntu.bsky.social
Great to see the typeset version of this invited review out. Covers pretty much everything we know about metabolites/peptides produced by Klebsiella spp. and how they interact with the host. #microsky #microbiomesky @microbiotaandhost.bsky.social doi.org/10.1530/MAH-...
Host interactions of bioactive molecules produced by Klebsiella spp
Abstract Klebsiella spp. are early colonisers and commensals of human skin, oral, nasal, throat and gut microbiotas, but are also opportunistic pathogens. Much of our information on these bacteria is ...
doi.org
New preprint out from Jack C. Leo and colleagues! #microsky
Formation of the β-sheet at the extracellular opening of the intimin β-barrel domain is necessary for stability and efficient passenger secretion
Attaching and effacing pathogens, such as enteropathogenic and enterohaemorrhagic E. coli, rely on an adhesin, intimin, for attachment to enterocytes and downstream effects leading to actin pedestal f...
biorxiv.org
Congratulations to @conmeehan.bsky.social and colleagues on the publication of their new manuscript. #microsky
Pitfalls of bacterial pan-genome analysis approaches: a case study of M. tuberculosis and two less clonal bacterial species
Abstract . Pan-genome analysis is a fundamental tool for studying bacterial genome evolution; however, the variety of methods used to define and measure th
academic.oup.com
🚨New publication🚨 We show that K. Pneumoniae bacteriophages can be incorporated into alginate to create an antibiofilm matrix effective against clinical K. pneumoniae strains academic.oup.com/jambio/artic...
Bacteriophage-embedded and coated alginate layers inhibit biofilm formation by clinical strains of Klebsiella pneumoniae
AbstractAims. This study aimed to determine the antibiofilm properties of Klebsiella pneumoniae phages previously isolated from Thai hospital sewage water.
academic.oup.com
First from the @arom-ntu.bsky.social group is @jodywinter.bsky.social who was awarded the 2024 Microbiology in Society Award. Jody is talking about education outreach and research as an invited talk.
Congratulations to Caitlin Wildsmith on the second paper from her PhD with @davidnegus.bsky.social! #microsky
Genomic and phenotypic characterization of staphylococci isolated from the skin of non-human primates
The growth of wildlife tourism coupled with continued deforestation has resulted in increased contact between non-human primates (NHPs) and humans. Such events may promote the transmission of potentia...
microbiologyresearch.org
Incredibly happy to see this paper come out! And first research paper for @lotox.bsky.social! Thanks also to all the collabs at @arom-ntu.bsky.social www.microbiologyresearch.org/content/jour...
Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative Escherichia coli O104:H4 outbreak strain
Enteroaggregative Escherichia coli O104:H4 is best known for causing a worldwide outbreak in 2011 due to the acquisition of a Shiga-like toxin alongside traditional enteroaggregative virulence traits;...
microbiologyresearch.org
Congratulations to PhD students Rachel and Lottie, and MRes student Martyna on their publication with @mcvickermicro.bsky.social! #microsky www.microbiologyresearch.org/content/jour...
Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative Escherichia coli O104:H4 outbreak strain
Enteroaggregative Escherichia coli O104:H4 is best known for causing a worldwide outbreak in 2011 due to the acquisition of a Shiga-like toxin alongside traditional enteroaggregative virulence traits;...
microbiologyresearch.org
Congratulations to @conmeehan.bsky.social and colleagues on their new publication!
Conor (Conchúr) Meehan@conmeehan.bsky.social · 2y agoWe published a cool new paper showing that some M tuberculosis lineages (mainly L1 and L6) seem less transmissible but that's mainly because they have longer initial non-infectious 'latent' periods. www.sciencedirect.com/science/arti...
New paper from @jodywinter.bsky.social's team on how menadione affects transcriptional responses of Helicobacter pylori. Well done to PhD students Stephen and Rebecca! #microsky #Helicobacter www.microbiologyresearch.org/content/jour...
Menadione reduces the expression of virulence- and colonization-associated genes in Helicobacter pylori
Novel treatment options are needed for the gastric pathogen Helicobacter pylori due to its increasing antibiotic resistance. The vitamin K analogue menadione has been extensively studied due to intere...
microbiologyresearch.org
We're running our introductory/launch event for LEAP tonight, unfortunately I can't attend as I'm full of a cold (not great look to start a super spreader event). Though LEAP we hope to bring in more public participation into our research, to find out more and keep up to date follow our BlueSky...
Listen, Engage and Analyse with the Public (LEAP)@leapntu.bsky.social · 2y agoTonight is our launch event for LEAP! We're going to be introducing the different topics and events and introduce everyone to the initiative!! Wish us luck, we will update how it goes... #ScienceSky
Deadline to apply for this PhD is 14 February.
Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU@arom-ntu.bsky.social · 2y agoPhD studentship available with Dr Jonathan Thomas. Use of Short Interfering RNA to Reduce Antimicrobial Resistance in Bacterial Clinical and Veterinary Pathogens www.ntu.ac.uk/study-and-co...
Deadline to apply for this PhD is 14 February.
Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU@arom-ntu.bsky.social · 2y agoPhD studentship available with @jodywinter.bsky.social. One Health drivers of antibiotic resistant bacterial infections in rural Ugandan communities www.ntu.ac.uk/study-and-co...
New year, new publication! From @conmeehan.bsky.social and colleagues @tlillebaek.bsky.social ek.bsky.social and @micronorman.bsky.social describing four new species of Mycobacterium.
Four novel nontuberculous mycobacteria species: Mycobacterium wendilense sp. nov., Mycobacterium burgundiense sp. nov., Mycobacterium kokjensenii sp. nov. and Mycobacterium holstebronense sp. nov. rev...
Four novel nontuberculous mycobacteria were discovered from a historical strain collection at the International Reference Laboratory of Mycobacteriology at Statens Serum Institut in Copenhagen, Denmar...
microbiologyresearch.org
Great end to the year for @arom-ntu.bsky.social, with three new publications out. 1. Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system - @mcvickermicro.bsky.social, Dr Jonathan Thomas
Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system | mBio
Our work addresses two processes, the maintenance of plasmids and antibiotic tolerance; both contribute to the development of antimicrobial resistance in bacteria that cause human disease. Here, we fo...
journals.asm.org
At Nottingham Trent University (NTU), we’re tackling some of the biggest health challenges in society; dementia, cancer, diabetes, obesity, and infections. But we can’t do it alone. Through our LEAP (Learn, Engage and Analyse with the Public) initiative, we want to hear your thoughts and (1/3)
Applied Microbiology International is here! Give them a follow @amiposts.bsky.social #microsky #microbiomesky
Congratulations to @conmeehan.bsky.social and colleagues on their recent publication! #microsky
Frameshift mutations in the mmpR5 gene can have a bedaquiline-susceptible phenotype by retaining a protein structure and function similar to wild-type Mycobacterium tuberculosis | Antimicrobial Agents...
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains the deadliest infectious disease and is particularly challenging to treat when it becomes drug-resistant. Bedaquiline (BDQ) is a recent...
journals.asm.org
New translational study from @bugsinyourguts.bsky.social and @drsimonmcarthur.bsky.social (at QMUL) showing how a microbiome-associated metabolite implicated in chronic kidney disease affects the blood–brain barrier. #microbiomesky
Professor Lesley Hoyles@bugsinyourguts.bsky.social · 2y agoDelighted to see this out, after a 2-year-long review process that left @drsimonmcarthur.bsky.social and I wondering what we'd done to upset the reviewing gods. #microbiomesky #gutbrainaxis www.tandfonline.com/doi/full/10....
Great to kick off #WAAW with a huge injection of enthusiasm from students who entered our NTU-Mak partnership's annual competition, producing engaging videos and comic strips to help raise awareness of AMR. Congratulations to the winners! All available at jodywinter.wixsite.com/waaw/waaw-2024
WAAW 2024 | Waaw
jodywinter.wixsite.com