Cannot be more excited about the lineup for the inaugural Function of Evolving Systems GRC conference I am co-organizing with the amazing Joy Bergelson. Less than a month away: August 9 - 14, 2026. Still a few spots left! And do check out the amazing list of speakers: www.grc.org/function-of-...

new preprint out! applying the Ewens distribution model to name choices of Catholic Popes (with a neat extension of Slatkin’s exact test to conditional configurations)

arXiv q-bio.PE Populations and Evolution@qbiope-bot.bsky.social · 3mo ago

Egor Lappo, Noah A. Rosenberg: Quo nomine vis vocari? A random-copying model explains the temporal sequence of papal names https://arxiv.org/abs/2605.07028 https://arxiv.org/pdf/2605.07028 https://arxiv.org/html/2605.07028

One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation

The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...

biorxiv.org

please come see my poster today 🥺🥺🥺 #smbe2025

new preprint from me! did you know that psi index is a hyperbolic tangent of the difference in drift between the two populations?

bioRxiv Genetics@biorxiv-genetic.bsky.social · last yr.

Coalescent theory of the {psi} directionality index https://www.biorxiv.org/content/10.1101/2025.06.18.660412v1

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

Drosophila Genetic Database

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

philanthropy.cam.ac.uk

How is functional variation at large-effect loci maintained in natural populations? Thrilled to share our work showing how beneficial dominance reversal helps fruit flies maintain a resistance polymorphism as selection varies in their environment! A thread 🧵 1/n www.biorxiv.org/content/10.1...

Dominance reversal maintains large-effect resistance polymorphism in temporally varying environments

A central challenge in evolutionary biology is to uncover mechanisms maintaining functional genetic variation1. Theory suggests that dominance reversal, whereby alleles subject to fluctuating selectio...

biorxiv.org

really happy to have participated in this project! this figure proves that a chromosome-scale sweep happened based on the time series of allele frequencies during the sweep (and even shows loci which have potentially swept independently).

Marianna Karageorgi@mkarag.bsky.social · 2y ago

One more surprise! W/ @egorlappo.me , we showed these rapid and large frequency changes of the resistant Ace drove a chromosome-scale sweep during insecticide selection and a reverse sweep after reversal of selection. Fluctuating selection's footprints extend far beyond the target! 16/n

new photo posts!! www.lappo.photo

did you ever need to run many SLiM simulations to understand the behavior of some popgen quantity? i have released a rust-based wrapper for SLiM that takes care of large-scale parallel runs over parameter grids! github.com/EgorLappo/sl... 1/

GitHub - EgorLappo/slim-runner: rust-based wrapper for SLiM population genetics simulation engine

rust-based wrapper for SLiM population genetics simulation engine - EgorLappo/slim-runner

github.com

Thrilled to share a new lab pre-print from graduate student Tris Dodge! Tris & co elegantly uncover the genetic underpinnings and fitness consequences of a sexual mimicry polymorphism in Xiphophorus birchmanni: www.biorxiv.org/content/10.1...

Complex structural variation and behavioral interactions underpin a balanced sexual mimicry polymorphism

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

hanging out at #tagc2024

It's conference application season! We in the Rosenberg Lab recently assembled a list of conferences and I thought it could be helpful for other folks doing theoretical population biology. List is below -- feel free to add any we missed!

my work on cultural evolution and transmission biases in chess is out today in Proceedings B! royalsocietypublishing.org/doi/10.1098/... humsci.stanford.edu/feature/stud...

Study reveals how cultural factors influence chess move choice

A new Stanford study that used population and statistical models to analyze 3.45 million chess games by master players reveals how cultural biases can influence

humsci.stanford.edu

i've been slacking off reading about phylogenetic networks and f-statistics, and instead posted some film photos from my trip to Melbourne egorlappo.me/posts/2023-0...

It seems to me that the time is ripe for a Bluesky thread about how—and maybe even why—to befriend crows. (1/n)

decided to start posting some of my film photos online! check them out here https://egorlappo.me/posts/2023-08-12-old-photos.html