Eimear Lagan
@eimearlagan.bsky.social
Post-doc @ IGC, University of Edinburgh Epigenetics | Paediatric cancer | Functional genomics
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas. www.biorxiv.org/content/10.1...
Great to see @jongminkmg.bsky.social’s preview of our work in @cp-molcell.bsky.social today! www.cell.com/molecular-ce...
Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma
In this issue, Lagan et al.1 apply genome-wide and tiling-scan CRISPR screens to uncover a key role for CBX4 and its central region in promoting the growth of diffuse midline glioma cells bearing the ...
cell.com
Congratulations to everyone involved in this collaborative effort. Read our web story here: edin.ac/4jeAkLw @cmvm-edinburghuni.bsky.social
Researchers uncover key player behind gene repression in rare brain tumour
Researchers have discovered an important molecular mechanism underlying diffuse midline glioma - an aggressive and currently incurable brain tumour that mostly affects children.
edin.ac
Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Online now:
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
Lagan, Gannon, et al. reveal that H3K27M-DMGs depend on a specific form of cPRC1 containing CBX4 and PCGF4. H3K27M alters H3K27me3 distribution, causing increased binding of CBX4-PCGF4-cPRC1 and oncogenic gene repression. CBX4’s ability to read H3K27me3 and to form a specific cPRC1 complex with PCGF4 makes it essential in DMG.
dlvr.it
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
