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Ece Eksi, PhD

@eksiece.bsky.social

Assistant Professor in the Division of Oncological Sciences, OHSU. Cancer Neuroscience; Spatial Biology; Prostate Cancer. https://www.eksilab.com

17 Posts399 Follower198 Folgt
Ece Eksi, PhD@eksiece.bsky.social · 4mo ago

We’re honored to be on the cover of @insight.jci.org this month! This work uncovers a key role for sympathetic nerve-CAF interactions in driving PDAC progression and remodeling the TME.

JCI insight@insight.jci.org · 4mo ago

Identifying a potential therapeutic vulnerability in pancreatic cancer: doi.org/10.1172/jci.... Featured on the Cover, @eksiece.bsky.social et al. report sympathetic nerve-fibroblast crosstalk drives nerve injury, fibroblast activation & matrix remodeling in pancreatic cancer.

Ece Eksi, PhD@eksiece.bsky.social · 5mo ago

Thrilled to share our newly published work in JCI Insight! insight.jci.org/articles/vie...

JCI Insight - Sympathetic nerve–fibroblast crosstalk drives nerve injury, fibroblast activation, and matrix remodeling in pancreatic cancer

insight.jci.org

OHSU Knight Cancer Institute@ohsuknight.bsky.social · 5mo ago

Researchers found that certain nerves, called sympathetic nerves, that play an integral role in the body’s “fight or flight” stress response, can support pancreatic tumor growth. #OHSUResearch:

Jeremy Borniger@jborniger.bsky.social · 8mo ago

www.cell.com/neuron/fullt... new paper from our group demonstrating how breast tumors dysregulate rhythms in the HPA axis to drive their own growth. Great collaboration with the @corina-amor.bsky.social and @cheadlelab.bsky.social labs @cshlnews.bsky.social

Aberrant hypothalamic neuronal activity blunts glucocorticoid diurnal rhythms in murine breast cancer

Gomez, Wu, et al. demonstrate that breast cancer promotes blunted glucocorticoid diurnal rhythms via disinhibition of PVNCRH neurons. Restoration of normal glucocorticoid rhythms via endogenous activa...

cell.com

Ece Eksi, PhD@eksiece.bsky.social · 11mo ago

Normalization of spatial proteomics data is a major barrier to translating these datasets into clinical practice. We present a universal normalization framework that harmonizes data across platforms, cancer types, and labs: www.cell.com/cell-reports...

Toward universal immunofluorescence normalization for multiplex tissue imaging with UniFORM

Wang et al. introduce UniFORM, a universal normalization pipeline for multiplex tissue imaging. UniFORM applies automatic rigid landmark registration to align intensity distributions at both the featu...

cell.com

Ece Eksi, PhD@eksiece.bsky.social · last yr.

Exciting new method in #cancerneuroscience: we're modeling nerve-cancer interactions in 3D using microgels! This is a fun collab with the Bertassoni Lab, who's been doing amazing work with the Biofabrication Hub @ohsuknight.bsky.social. Check out their latest here: pubs.rsc.org/en/content/a...

Engineering neuronal networks in granular microgels to innervate bioprinted cancer organoids on-a-chip

Organoid models are invaluable for studying organ processes in vitro, offering an unprecedented ability to replicate organ function. Despite recent advancements that have increased their cellular comp...

pubs.rsc.org

Cold Spring Harbor Laboratory@cshlnews.bsky.social · last yr.

How do nerves influence cancer? CSHL is shaping the future of #CancerNeuroscience with the field’s first hands-on training course, equipping researchers with cutting-edge techniques that will help define the future of the field.

CSHL holds first-ever cancer neuroscience course | Cold Spring Harbor Laboratory

The brain controls the body, in large part, through nerves. So, what happens when nerves form new connections with tumors? How does the nervous system drive cancer progression? How do these interactio...

cshl.edu

Ece Eksi, PhD@eksiece.bsky.social · 2y ago

Need a distraction to shift your TMEntality today? If you’re curious about how sympathetic nerve signaling rewires immune and non-immune stromal cells in the TME, dive into this review article by Ariana Sattler and the team to reimagine the TME! link.springer.com/article/10.1...

Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity” - Cancer and Metastasis Reviews

Nerve signaling within the tumor microenvironment (TME) plays a critical role in the initiation, progression, and metastasis of solid tumors. Due to their highly responsive behavior and activation upo...

link.springer.com

Ece Eksi, PhD@eksiece.bsky.social · 2y ago

Neurosignaling is recognized as a key factor in cancer progression, yet current spatial profiling approaches are unable to detect neuronal innervation in the TME. www.cell.com/heliyon/full...

AxonFinder: Automated segmentation of tumor innervating neuronal fibers

Neurosignaling is increasingly recognized as a critical factor in cancer progression, where neuronal innervation of primary tumors contributes to the disease's advancement. This study focuses on segmenting individual axons within the prostate tumor microenvironment, which have been challenging to detect and analyze due to their irregular morphologies. We present a novel deep learning-based approach for the automated segmentation of axons, AxonFinder, leveraging a U-Net model with a ResNet-101 encoder, based on a multiplexed imaging approach.

cell.com