Saturday Spotlight💫: Presenting the first mouse model of Addison’s disease: doi.org/10.1172/jci.... Andreyeva et al. report on how immune cells destroy the adrenal glands in Addison's disease and identify IFNG as a promising target for future therapies.

This video shows the restoration of mitochondrial motility in ALS iPS-derived motor neurons. Oikawa et al. report the MA-5 improves mitochondrial function and ameliorates ALS phenotypes in Drosophila, patient-derived fibroblasts, and iPSC-derived motor neurons: doi.org/10.1172/jci....

Therapeutic approaches for polycystic kidney disease (PKD) have largely been focused on eliminating cysts. Remadevi et al. demonstrate that fibrosis is a promising therapeutic target for PKD that can reduce kidney scarring and preserve kidney function. doi.org/10.1172/jci....

Immune cells ring the alarm! doi.org/10.1172/jci.... Zhang et al. use a multiomic approach to reveal how immune cells communicate to other hepatic cells after liver surgery and identify a potential target to reduce inflammation and liver damage.

The immediate effects of vaping have long-term consequences 🚬 doi.org/10.1172/jci.... Irina Petrache & team show that short-term e-cigarette use damages lung cells, impairs repair, and weakens antiviral defenses, raising concerns about long-term health risks.

Nice piece of work. We are proud to have contributed our expertise to this publication: JCI Insight - IFN-γ–producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease insight.jci.org/articles/vie...

JCI Insight - IFN-γ–producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease

1Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.

insight.jci.org

New from #NephFaculty Dr Ortiz-Melo and Dr Coffman in JCI Insight Proximal tubule ACE2 mediates early responses to hypertension by regulating intrarenal RAS and sodium homeostasis https://insight.jci.org/articles/view/179960

Blood-clotting complications in pediatric pneumonia infection can be life threatening. Huang et al. discover neutrophils promote thrombosis in pneumonia caused by Mycoplasma pneumoniae via NET-mediated endothelial activation involving TLR2 and JAK–STAT3 signaling: doi.org/10.1172/jci....

ICYMI💫: The GI symptoms that impair quality of life in childhood neurodegenerative disorders may be because bowel enteric neurons are also affected. In this Research Letter, Ziółkowska et al. characterize enteric pathology in MPSIIIA mice: doi.org/10.1172/jci.... @pattidickson.bsky.social

This Week in Research💫: Combination treatment offers a promising therapeutic approach for prostate tumors exhibiting lineage plasticity. Storck et al. report combined BET bromodomain & DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer: doi.org/10.1172/jci....

This study marks an important step toward future clinical use of a urinary factor as a biomarker of recovery in acute interstitial nephritis: doi.org/10.1172/jci.... Qian et al. report urine Leukemia Inhibitory Factor (LIF) predicts kidney function recovery in patients with AIN

Unveiling a signaling pathway with implications for pediatric cardiovascular diseases associated with right ventricular pressure overload: doi.org/10.1172/jci.... Hu et al. show that RVPO impairs cardiomyocyte maturation via the MEF2D/BIN1 axis & restoring BIN1 rescues the defect

Combination treatment offers a promising therapeutic approach for prostate tumors exhibiting lineage plasticity: doi.org/10.1172/jci.... Storck et al. report Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.

Presenting the first mouse model of Addison’s disease: doi.org/10.1172/jci.... This issue’s Cover features work from Andreyeva et al., reporting on how immune cells destroy the adrenal glands in Addison's disease and identifying IFNG as a promising target for future therapies.

Adding a new perspective to STAT3 gain-of-function variants: doi.org/10.1172/jci.... Henrickson & team discover STAT3 GOF drives CD8+ T cell dysfunction, in part through a dysregulated purinergic axis, which is partially restored by targeted JAK inhibitor therapy.

Neonates have increased susceptibility to bacterial sepsis Here, Annamanedi et al. study murine neonatal sepsis induced by E. coli. and offer IL-27 neutralization as a new treatment strategy: doi.org/10.1172/jci....

Shamseldin et al. discover Bordetella pertussis T-cell antigens that, in an experimental subunit vaccine, induced protective T cell responses and reduced respiratory bacterial burden in mice: doi.org/10.1172/jci....

Sunday Spotlight💫: This review by Haikuo Li @haikuoli.bsky.social & colleagues aims to equip researchers with an understanding of the current technological landscape and to accelerate the adoption of spatial multiomics methods in biomedical research: doi.org/10.1172/jci....

Reader's Pick: Our most-accessed article in the past 30 days💫 : Apelin analog treatment reverses severe pulmonary arterial hypertension and right ventricular heart failure from Vu et al.: doi.org/10.1172/jci....

A new urine test may help doctors diagnose cystinosis earlier, potentially improving care for children with this rare kidney disease. doi.org/10.1172/jci..... Greenberg et al .provide a proof-of-concept study on the use of urine YKL-40 as a biomarker.

JCI Insight - Stabilization of the PP2A-B56α complex overcomes venetoclax-azacitidine resistance by impairing OXPHOS in AML insight.jci.org/articles/vie...

Transcriptional profiling of autoimmune myositis model recapitulates human immune signatures. doi.org/10.1172/jci..... Li et al. reveal a population of resident memory T cells in a murine HRS-induced myositis model that is also seen in patients. @SLG1717.bsky.social

This year’s theme for #PeerReviewWeek is Peer Review Capacity: Volume, Speed, and Quality. In today's changing publishing landscape, we commend our reviewers for meeting the demands, maintaining the highest standards, and staying true to the peer review process. Thank you Reviewers! #PRW #PRW2026

Miller et al. developed a single-cell atlas of polycystic kidney disease that integrates multiple disease models: doi.org/10.1172/jci.... The atlas identified the involvement of osteopontin across models and in human patients. The atlas: bmblx.bmi.osumc.edu/scPKD/ @daniyaljafree.bsky.social

The gastrointestinal symptoms that impair quality of life in childhood neurodegenerative disorders may be because bowel enteric neurons are also affected. In this Research Letter, Ziółkowska et al. characterize enteric pathology in MPSIIIA mice: doi.org/10.1172/jci.... @pattidickson.bsky.social

This review by Haikuo Li @haikuoli.bsky.social & colleagues aims to equip researchers with an understanding of the current technological landscape and to accelerate the adoption of spatial multiomics methods in biomedical research: doi.org/10.1172/jci....

Suggesting a novel therapy for systemic sclerosis: doi.org/10.1172/jci.... @eduardomarban.bsky.social & team report that an orally delivered noncoding RNA (TY1) reduces inflammation and organ fibrosis in models of systemic sclerosis through inhibition of the cGAS/STING axis. @the-asci.org

Weekend read💫 : Genes & environment influence the development of asthma. Here, Otoshi et al., investigate how genetic background & retinoid micronutrient perturbations affect lung developmental programs associated with airway hyperresponsiveness in mice: doi.org/10.1172/jci....

Spotlight 💫: Could platelets serve as a therapeutic target in alcohol-associated hepatitis? doi.org/10.1172/jci.... Matthew J. McConnell & colleagues report platelets upregulate inflammatory mediators in alcohol-associated hepatitis that can contribute to liver inflammation. #livertwitter #AlcHep

The heart’s halo: doi.org/10.1172/jci.... Hassanabad et al. discover immune cells in the pericardial fluid have anti-fibrotic properties. The team found macrophages that surround the heart release a factor (cystatin C) that prevents scarring following a heart attack.