How can we record the mechanical activity of cells in three dimensions? Our DNA force-history probes convert transient piconewton forces into persistent fluorescent signals, revealing spheroid activity, cellular protrusions, and migration tracks in a 3D matrix. www.biorxiv.org/content/10.6...

A good teaser for our recent story on lipid-protein interactions by @cookkate.bsky.social with really kind quotes by @jeremybaskin.bsky.social (Thanks!!)

Robert Arkowitz@robertarkowitz.bsky.social · 3w ago

www.pnas.org/post/journal...

How can we record the mechanical activity of cells in three dimensions? Our DNA force-history probes convert transient piconewton forces into persistent fluorescent signals, revealing spheroid activity, cellular protrusions, and migration tracks in a 3D matrix. www.biorxiv.org/content/10.6...

Excited that the first #DyNAtrix 🧬 Pilot kits from @dynamicmatrices.bsky.social are now available at PELO Biotech GmbH General info: dynamicmatrices.eu/dynatrix/ Try the Ready-to-Use kit: www.pelobiotech.com/en/contact/?... Minimal Discovery kit: www.pelobiotech.com/en/contact/?... #CellCulture

Thanks to Advanced Materials for selecting our article on "Olympic" gels for a cover! 🔗🔗🔗🔗🔗🔗🔗🔗🔗 advanced.onlinelibrary.wiley.com/doi/abs/10.1... #MaterialsScience #Biotechnology #Nanotechnology

Looking forward to speak at the upcoming Leibniz HealthTech Lecture: "Dynamic Matrices – a material platform for precisely controlled cell culture and ultra-selective biomolecule isolation" 🌍 online 📅 May 4th | 13:30-15:00 (CEST) 🔴 Register here: www.leibniz-healthtech.de/en/news/even...

Leibniz HealthTech Lecture: Dynamic Matrices - a material platform for precisely controlled cell culture and ultra-selective biomolecule isolation

leibniz-healthtech.de

Working on this collaborative project in the Krieg lab has been a real pleasure. It began as a side ninja project with almost no budget but has grown and expanded so much. Really proud of what we have accomplished🥺 please check it out: advanced.onlinelibrary.wiley.com/doi/10.1002/...

Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings

Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and f...

advanced.onlinelibrary.wiley.com

Elisha Krieg@elishakrieg.bsky.social · 6mo ago

🔴Finally out TODAY in Advanced Materials: “Assembling a True Olympic Gel From over 16 000 Combinatorial #DNA Rings” #MaterialsScience #Nanotechnology Explainer thread below 👇👇👇

🔴Finally out TODAY in Advanced Materials: “Assembling a True Olympic Gel From over 16 000 Combinatorial #DNA Rings” #MaterialsScience #Nanotechnology Explainer thread below 👇👇👇

Just out in @angewandtechemie.bsky.social! #LASSO a new method for ultra-selective isolation of biomolecules (DNA, RNA, or protein). This method uses a unique polymer phase separation mechanism to gently capture and pull down specific target sequences.

More great news for the holidays🎄 Our new review on "Functionalizing Nucleic Acids: Synthesis and Purification Strategies for Bioconjugates as Biomaterials" is out: onlinelibrary.wiley.com/doi/10.1002/... Many thanks to Nico Alleva, Jian Zhang and Torsten John!

Functionalizing Nucleic Acids: Synthesis and Purification Strategies for Bioconjugates as Biomaterials

Nucleic acid-ligand conjugates combine the distinct properties of macromolecular ligands with the versatility of DNA/RNA nanotechnology. In biomaterial and nanomedicine applications, highly purified ...

onlinelibrary.wiley.com

Thanks to Advanced Functional Materials for highlighting our work on their back cover!

Big congrats to Dr. Krishna Gupta for winning the best poster prize at Oxford Global’s NextGen Omics conference in London, where he presented our work on #LASSO pulldown polymers. 💪 LASSO is a new general-purpose method for fast and ultra-selective biomolecule purification.

Fresh in @natchemeng.nature.com Growing artificial cytoskeleton in the viscoelastic confinement of DNA Artificial Cells. Brilliant work bey Weixiang! #Syntheticcell #systemschemistry www.nature.com/articles/s44...

Growing functional artificial cytoskeletons in the viscoelastic confinement of DNA synthetic cells - Nature Chemical Engineering

Engineering structurally and functionally complex synthetic cells remains a key challenge. Here DNA condensate synthetic cells combine phase separation and DNA nanostructures to reveal how switchable ...

nature.com

Congratulations to Soumya and Charu for making the first ATP-fueled homeostatic cytokine delivery system for communication between artificial and living cells. Now in Angewandte Chemie @angewandtechemie.bsky.social #syntheticcell #noneqsys #DNAnanoscience onlinelibrary.wiley.com/doi/10.1002/...

ATP‐Powered Signaling Between Artificial and Living Cells

We introduce an ATP-powered artificial cell platform capable of selectively and transiently releasing DNA signals to facilitate communication between artificial and living cells. By engineering these...

onlinelibrary.wiley.com

Multiplexed detection of viral pathogens on an AUTONOMOUSLY LOADING chip for point-of-care #diagnostics. Congrats to first authors Beatrise Berzina and Krishna Gupta and the entire EKFZ-funded *VirChip* team!

Schering Young Investigator Award 2025 by the Schering Stiftung for Agnes Toth-Petroczy @tothpetroczylab.bsky.social @mpi-cbg.de @csbdresden.bsky.social. She receives the award for her work on the evolution, diversity, and function of proteins. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...

New Perspectives on the Hidden World of Proteins

 Schering Young Investigator Award 2025 goes to Agnes Toth-Petroczy

mpi-cbg.de

This is doing the rounds in my messages with colleagues, and is a very real threat to the field of microscopy 😬. Given one (published) microscope image probably costs between $100 and $10,000 (or more) to make - the lure of "oh I will just ChatGPT it" is very much there.

Elisha Krieg@elishakrieg.bsky.social · 12mo ago

AI can now generate fake microscopy images that are nearly impossible to detect. A serious threat to scientific integrity—and we’re not prepared for it. Commentary in @natnano.nature.com #nanotechnology

AI can now generate fake microscopy images that are nearly impossible to detect. A serious threat to scientific integrity—and we’re not prepared for it. Commentary in @natnano.nature.com #nanotechnology

Exciting application of our programmable #CellCulture matrix #DyNAtrix. By creating a mechanically reconfigurable microenvironment, we can now invert & guide epithelial cell polarity in real time. #DNAnanotech 1/ 🧵