We begin the New Year with two preprints on hypothalamic development. The first, part of a long-term collaboration with Marysia Placzek’s group, investigates the organization of the developing forebrain, and show that current models are (mostly) incorrect./1 www.biorxiv.org/content/10.1...

Resolving forebrain developmental organisation by analysis of differential growth patterns

The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...

biorxiv.org

Our second preprint, which was spearheaded by @thomasdwkim.bsky.social, uses single-cell multiomic analysis to identify gene regulatory networks controlling neurogenesis and cell fate specification in mouse hypothalamus and prethalamus./1 biorxiv.org/cgi/content/...

Brought to life through the magic of Blender... For more details and more movies go to our preprint www.biorxiv.org/content/10.1...

Our second New Year preprint on hypothalamus development, led by @thomasdwkim.bsky.social Major insights into hypothalamic GRNs, functionally tested in mutants, and behavioural importance of prethalamus-derived inhibitory neurons @sethblackshaw.bsky.social www.biorxiv.org/content/10.1...

Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development.

Neuronal subtypes derived from the embryonic hypothalamus and prethalamus regulate many essential physiological processes, yet the gene regulatory networks controlling their development remain poorly ...

biorxiv.org

Excited to present our new preprint clarifying forebrain developmental organisation. Complex growth patterns shape the forebrain but distort the A-P + D-V axes, hence prior confusion over brain layout. Big love for chicken embryos, simpler to interpret than mouse 🐣1/3 www.biorxiv.org/content/10.1...

Resolving forebrain developmental organisation by analysis of differential growth patterns

The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...

biorxiv.org