Elizabeth Manning
@emmanning.bsky.social
Forebrain development, hypothalamus patterning, early morphogenesis. Postdoctoral Researcher with Marysia Placzek at The University of Sheffield
Well done to @elsieplace.bsky.social, Marysia Placzek and @sethblackshaw.bsky.social for this beautifully clear overview of a very complex history of brain developmental models www.sciencedirect.com/science/arti...
Reassessing forebrain organization: recent evidence challenges the prosomere model
For over three decades, the prosomere model has influenced our understanding of vertebrate brain development by proposing that the forebrain consists …
sciencedirect.com
I illustrated my way through the @bsdb.bsky.social Spring Meeting a couple weeks ago - here's my illustrated summary of the conference! I sketched (almost) all the speakers and glimpses of the science that made it such a great few days.
#DBfeature 🧠 FGF10 operates with SHH and BMP to contribute to neurogenic and gliogenic fates in the puberal hypothalamus By K Chinnaiya, I Groves, E Manning, E Place, C Furley, SE Strawbridge, AG Fletcher, M Placzek tinyurl.com/muee82sm
Government-Funded infomercial from Norway striking back at US corporations and the tech Bros for filling the Internet with slop. youtu.be/T4Upf_B9RLQ?...
A Day in the Life of an Ensh*ttificator
YouTube video by Forbrukerrådet - Norwegian Consumer Council
youtu.be
Excited to finally share the final/final.doc version of our paper. It's been a journey, but very proud of the result. Well done to all involved, especially @elsieplace.bsky.social @kchinnaiya.bsky.social , @thomasdwkim.bsky.social, @sethblackshaw.bsky.social 👏👏 www.nature.com/articles/s41...
Resolving forebrain developmental organisation by analysis of differential growth patterns - Nature Communications
Experiments on the embryonic chick brain reveal distinct directional growth patterns and a tripartite hypothalamus, challenging the classic segmented prosomere model and offering an updated view of ho...
nature.com
Very happy to share our latest article in @natcomms.nature.com ! Also very pleased to be a featured article (beautiful artwork from @elsieplace.bsky.social depicting early chick neurectoderms at increasing stages of development. (waiting patiently in space for the right moment to attack the Earth?)
Nature Communications@natcomms.nature.com · 7mo agoNew featured article! Resolving forebrain developmental organisation by analysis of differential growth patterns @emmanning.bsky.social @elsieplace.bsky.social @kchinnaiya.bsky.social @sethblackshaw.bsky.social @thomasdwkim.bsky.social http://dlvr.it/TQLWh5
A very good, entertaining and frankly terrifying look at neural networks and AI www.youtube.com/watch?v=jrK3...
AI: What Could Go Wrong? with Geoffrey Hinton | The Weekly Show with Jon Stewart
YouTube video by The Weekly Show with Jon Stewart
youtube.com
“Developmental biology is fundamentally beautiful. We are no less beautiful for our variation. Instead, perhaps we are more so. Perhaps we are remarkable. Perhaps we are full of wonder.” Read this insightful post by Bethan on the Node. thenode.biologists.com/developmenta... #Disability
Developmental Biology and Disability - the Node
Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.
thenode.biologists.com
Looking forward to the #biologists100 conference in Liverpool next week! I’m creating a thread below to link to my poster (in collaboration with @elsieplace.bsky.social) so we can share our 4D model of forebrain development. Come visit us: Poster 200, Session 2 on Wednesday.
Need to electroporate and/or live image avian embryos? We hope our new preprint will help you get started: www.biorxiv.org/content/10.1... Open EGGbox: an open-source 3D-printed embryonic Gallus gallus toolbox for electroporation and culture/live imaging of avian embryos ex ovo 🧪🐣 #devbio
This is a profoundly evil betrayal and a direct reflection of Trump's soul—a disgusting, small, and shameful ghoul who gets off on harming the powerless. www.reuters.com/world/us/tru...
Exclusive: Trump plans to revoke legal status of Ukrainians who fled to US, sources say
U.S. President Donald Trump's administration is planning to revoke temporary legal status for some 240,000 Ukrainians who fled the conflict with Russia, a senior Trump official and three sources familiar with the matter said, potentially putting them on a fast-track to deportation.
reuters.com
New! 15y after the classic Aigouy et al "Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium..." from lab of much missed Suzanne Eaton, we provide our take from post-doc Sara Tan "Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing". rdcu.be/d81Vn
Check out our fabulous 4D model of forebrain development, created in Blender from imported light sheet scans of HH10-20 dissected chick neuroepithelium, and painstakingly linked together by @elsieplace.bsky.social by combining published fate maps with 100's of our own samples.
Excited to present our new preprint clarifying forebrain developmental organisation. Complex growth patterns shape the forebrain but distort the A-P + D-V axes, hence prior confusion over brain layout. Big love for chicken embryos, simpler to interpret than mouse 🐣1/3 www.biorxiv.org/content/10.1...
Resolving forebrain developmental organisation by analysis of differential growth patterns
The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...
biorxiv.org
Great work from @thomasdwkim.bsky.social and @sethblackshaw.bsky.social labs
Seth Blackshaw@sethblackshaw.bsky.social · 2y agoOur second preprint, which was spearheaded by @thomasdwkim.bsky.social, uses single-cell multiomic analysis to identify gene regulatory networks controlling neurogenesis and cell fate specification in mouse hypothalamus and prethalamus./1 biorxiv.org/cgi/content/...
We begin the New Year with two preprints on hypothalamic development. The first, part of a long-term collaboration with Marysia Placzek’s group, investigates the organization of the developing forebrain, and show that current models are (mostly) incorrect./1 www.biorxiv.org/content/10.1...
Resolving forebrain developmental organisation by analysis of differential growth patterns
The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...
biorxiv.org
